Posted by AndrewB on May 30, 2000, at 3:42:10
In reply to Re: Nardil - Judy , posted by Peter S. on May 29, 2000, at 16:02:11
Peter,
Glad to hear that you have had a response to Nardil.
If you don't mind me asking, can you tell me your diagnosis and in what specific ways Nardil has improved your condition.
Also will you please give me any details you can about your amisulpride experience. I am trying to track peoples' responses.
The constipation combined with sexual side effects you describe reminds me of the side effects sometimes seen with certain antidepressants that act on norepinephrine such as reboxetine and some tricyclics. Nardil also acts on NE through its MAO inhibition. Nardil has a complicated action, one which I don't understand. Therefore it isn't for me to say that the constipation and sexual dysfunction is NE related, but it is only my point to suggest it as a one likely cause.
More specifically, it may be agonism of the alpha 2 receptor that is causing your constipation. The side effects of alpha 2 agonist drugs (used for hypertension) include constipation, drowsiness, sedation, dizziness,and hypotension.
This suggests a potential remedy for your condition, an alpha 2 selective agonist. Yohimbine is one such drug. Yohimbine, may people know, can be very effective in assisting some to overcome sexual dysfunction. When you take it, onset of action will take about 2 hours and effects can last for 24 hours. Side effects of yohimbine for many include agitation, insomnia, and a rise in blood pressure. Of course, if you are feeling sluggish, you may welcome these side effects. I would be very interested to know, if you try yohimbine, if it doesn't take away your constipation also.
Yohimex is a prescription medicine that is made of purified yohimbine. It is economical and has less side effects than yohimbine bark. You may want to talk to your psych. about the appropriateness of Yohimex (or another alpha 2 antagonist?) for your condition.
Bethanechol has also been noted to reverse sexual dysfunction of norandrenergic origen.
AndrewB
poster:AndrewB
thread:34436
URL: http://www.dr-bob.org/babble/20000526/msgs/35184.html