Posted by SLS on May 26, 2000, at 7:24:42
In reply to Re: My Mirapex Trial, posted by JohnL on May 26, 2000, at 3:29:47
> Andrew,
> You mentioned trying St Johnswort? That's pretty cool. I'm sure you are aware of the brands to stick with.
>
> Just a note on dose size, for trivia, for whatever it's worth. That is, I responded best at 600mg a day. I felt improvement during the first week. So I knew SJW was on target. No trickle down effect needed. But of course, I am very aware of the 2700mg doses used in some clinical trials. So I figured if 600mg was good, I might as well head up towards 2700mg. But around 1500mg I realized things weren't as good. Back to 900mg to 1200mg got a little better. But at 600mg to 900mg I get the best response. Weird. I guess it's true, more is not always better. I think with all of us there must be a unique therapeutic window. Mine has proven to be in the 600mg to 900mg range.
> I think SJW and Amisulpride is a pretty cool combination. While Amisulpride is stimulating dopamine, SJW is preventing it's reuptake. And simultaneously it's also providing reuptake inhibition of NE and serotonin, all in approximately equal proportions. But of course, with the Amisulpride, the bias of treatment is on dopamine. SJW also lowers prolactin, which helps counter Amisulpride's effect of raising prolactin. Not to mention whatever else there is about SJW that we don't know yet.
Hi John.You've sparked my interest about some of the specific pharmacological properties SJW has.
For instance, dopamine reuptake inhibition. Where can I find information about this drug?That SJW demonstrates a therapeutic window for you seems like it would be an important clinical observation that would be critical for its successful use. Have you seen this addressed in anything you have read? Perhaps you ought to submit your observations to a SJW website or newsgroup.
As always, thanks for writing stuff.
- Scott
poster:SLS
thread:34012
URL: http://www.dr-bob.org/babble/20000526/msgs/34703.html