Posted by JohnL on May 26, 2000, at 3:29:47
In reply to My Mirapex Trial, posted by AndrewB on May 19, 2000, at 12:49:39
> I have just finished a two week trial with the D2/D3 agonist Mirapex, the last week of the trial I did not take any other medications besides reboxetine. As an antidepressant and anxiolytic, Mirapex seemed to have little or no effectiveness for me. Taking only the Mirapex, I became quite depressed and socially anxious. My energy was good, but this was probably maintained by the reboxetine. For my condition at least, Mirapex appears to be very much inferior to the D2/D3 presynaptic antagonist amisulpride. I have dysthymia with social anxiety. It is possible that this trial was too short to give Mirapex a chance to work, though it is normally effective within a week. Also it is possible that my dosage was too small. I was taking what limited studies indicate is the normal amount.
Andrew,
You mentioned trying St Johnswort? That's pretty cool. I'm sure you are aware of the brands to stick with.Just a note on dose size, for trivia, for whatever it's worth. That is, I responded best at 600mg a day. I felt improvement during the first week. So I knew SJW was on target. No trickle down effect needed. But of course, I am very aware of the 2700mg doses used in some clinical trials. So I figured if 600mg was good, I might as well head up towards 2700mg. But around 1500mg I realized things weren't as good. Back to 900mg to 1200mg got a little better. But at 600mg to 900mg I get the best response. Weird. I guess it's true, more is not always better. I think with all of us there must be a unique therapeutic window. Mine has proven to be in the 600mg to 900mg range.
I think SJW and Amisulpride is a pretty cool combination. While Amisulpride is stimulating dopamine, SJW is preventing it's reuptake. And simultaneously it's also providing reuptake inhibition of NE and serotonin, all in approximately equal proportions. But of course, with the Amisulpride, the bias of treatment is on dopamine. SJW also lowers prolactin, which helps counter Amisulpride's effect of raising prolactin. Not to mention whatever else there is about SJW that we don't know yet.
Anyway, I guess it's a flip of the coin whether it will be helpful to you or not, but I'm wishing you the best.
Johnl
poster:JohnL
thread:34012
URL: http://www.dr-bob.org/babble/20000517/msgs/34696.html