Posted by Arias on May 16, 2000, at 21:34:07
In reply to Slugs. Off the subject. Cam, posted by allisonm on May 15, 2000, at 8:36:46
Alison,
I was on Wellbutrin otherwise known as Zyban for a time, 150 mg 2x/day, sustained-release. In a word, it was a dream. I'd tried the SSRI's with the consequent sedation, anorgasmia without effect on the depression itself. Officially, it's a norepinephrine and dopamine reuptake inhibitor but from these prior posts, I don't think so anymore :) It did however work for the depression.
However, there is the issue of anorexia as it suppresses the appetitite and the not-insignificant issue of seizures which occurs at a higher frequency in those with a history of eating disorders and those with a history of seizures. Something like 1.2%. I frankly don't understand this however, mechanism-wise, and there is a spectrum of eating disorders but anyway.
However, this can be mitigated with the following measures: take the medicine regularly, and separated by 8 hours apart. Don't take it after 4-5 p.m., also because wellbutrin tends to adversely affect sleep. Seizures tend to occur at higher dosages, 450 mg/day and higher. Additionally, drop the alcohol with Wellbutrin. And of course, if you have a history of an eating disorder or a seizure disorder, consider another drug.
Despite my hearty thumbs-up concerning wellbutrin, I did have one episode of a seizure with it; but I did not always follow these precautions and additionally, it may have something to do with the individual's body's metabolizing system, the cytochromes etc.
Best of luck to you my friend.
poster:Arias
thread:33345
URL: http://www.dr-bob.org/babble/20000508/msgs/33719.html