Posted by Scott L. Schofield on April 13, 2000, at 10:08:18
In reply to Re: Uprima/Fred, posted by Scott L. Schofield on April 13, 2000, at 7:51:08
Although of Uprima (apomorphine) can be made to induce copulatory behavior when injected into specific areas of the brain in rats, I have not encountered anything to suggest that oral or parenteral administration results in increased libido in humans. It may prove itself to do so, but I don't find enough medical literature on Medline to indicate this with any confidence. The CNN report seems accurate.
Apomorphine has long been recognized as being capable of producing erections. There seem to be two mechanisms involved.
1. Stimulation of the medial preoptic area and/or paraventricular nucleus of the hypothalamus.
- I believe these are the same mechanisms involved in the induction of the nocturnal erections that occur during rapid eye movement sleep (REM).
* The preoptic area may also be involved with libido.2. Increasing the pressure of the "balloon" (corpus cavernosum) located within the penis, causing it to grow in size and stiffness.
Among the more important observations regarding this issue is the lack of the ability of apomorphine to reverse the decrease of libido in mice caused by the loss of testosterone brought about through castration.
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For Andrew:Apomorphine is one of those drugs that produce opposite effects at low dosages versus high dosages. Apomorphine represents the antithesis of sulpiride and amisulpride. Low dosages produce sedation, while high dosages produce activation and stereotypic behavior. Presynaptic versus postsynaptic regulation.
- Scott
poster:Scott L. Schofield
thread:29285
URL: http://www.dr-bob.org/babble/20000411/msgs/29833.html