Posted by Kev on February 2, 2000, at 21:22:04
In reply to Re: Serzone and MDMA, posted by neuroblast on February 2, 2000, at 17:50:48
> It's funny watching know-it-alls come up with their own theories made up of a mishmash of media lies, "personal experience," and short term studies that are inconclusive. Scientists are only scratching the surface of the neurochemistry of MDMA in the human brain. MDMA does cause pruning of seratonin axons and fine serotonergic arborizations, 5HT and 5HT2 receptors, failure of 5HT synthesizing enzymes, as well as depletion of the brain's store of seratonin up to 80%throughout the human brain, not simply in localized areas. Areas of profound damage include the prefrontal cortex, frontal cortex, hippocampus, and the medial and dorsal raphe nuclei to name a few. It does not kill the cell bodies, and serotonergic pathways and functions are restored to normal function after 4-12 months. The significance of this is that your memory and ability to think may be impaired after taking multiple doses of MDMA; the damage is temporary. As far as Serzone is concerned, it blocks the reuptake of seratonin as well as being a 5HT receptor agonist. Being a receptor agonist, this will heighten the effects of MDMA. Instead of Serzone, 1 hour after ingesting MDMA, an SSRI such as prozac, paxil or zoloft should be taken to protect against neurotoxic effects. As far as MDMA is concerned, I recommend taking it. It's fantastic, and will make you forget what depression feels like for 5 hours. Don't do it regularly, and ALWAYS take an SSRI with it, because it will save your brain. If you somehow can get a hold of a dopamine and seratonin SRI, which I believe Effexor is, this would be better than an SSRI as dopamine oxidation has been implicated in MDMA's neurotoxic effects.
***A couple cans of Holsten Festbock and a good cigar will also make you forget what depression is like for a few hours.
-Kev
poster:Kev
thread:902
URL: http://www.dr-bob.org/babble/20000128/msgs/20411.html