Posted by Harry Anslinger on January 2, 2000, at 19:44:52
In reply to Re: drug sins and serotonin syndrome, posted by Elizabeth on December 31, 1999, at 4:23:46
> Hey guys, just from clinical experience it's *MAOIs*, not SSRIs, that can cause the central serotonin syndrome if you take MDMA with them!
>
> > 1. Since he would discontinue the SSRI at least SEVERAL DAYS previous to doing MDMA, this should be no special risk -- unless you have new info on the half lives of SSRIs. It is like MDMA alone.
>
> Actually this isn't true; while the SSRI goes away after a few days (exception: Prozac), it has longer-lasting effects that persist for a while after the drug is out of your system. Hence the lengthy wait between quitting an SSRI and starting an MAOI.You didn't mention what that effect is. There is a lengthy wait but that is limited to Prozac(fluoxetine). Other SSRIs have a washout period of 5-7 days. (see reference in previous message)
Don't confuse action and effect. An SSRI action begin with the first dose but the antidepressant effect is delayed. Similarly, neural changes responsible for the antidepressant effect generally persist -- at least for a period of time -- after the SSRI is discontinued (and eliminated from the body). Normalization of 5-HT receptors is not the same action or risk factor as 5-HT reuptake inhibition, re serotonin syndrome.
> > 2. Any SSRI that might remain (very minimal) also inhibits entry of MDMA into the neuron, and interferes with its release of serotonin.
>
> Yup, that's my understanding of why SSRIs tend to block the effect of MDMA.
>
> > Here's some true/false statements for Cindy:
> > -- Marijuana causes aggression.
> > -- LSD causes chromosone damage.
> > -- This is your brain on drugs (eggs frying).
> > -- The ends justify the means.
>
> Don't forget "post hoc ergo propter hoc." :)
>
> > The real danger of misinformation is that people learn to distrust the source -- in this case valid warnings also.
>
> "Wolf!"Just Grandma!!!
poster:Harry Anslinger
thread:17636
URL: http://www.dr-bob.org/babble/20000101/msgs/17862.html