Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: drug sins and serotonin syndrome

Posted by Bruce on December 31, 1999, at 19:47:52

In reply to drug sins and serotonin syndrome, posted by Drug Czar on December 30, 1999, at 13:50:08

> All I saw that Greg was *seeking* was information. Most of what he was offered was information he didn't ask for.
> As for consequences, you are right that serotonin syndrome is a relative risk. But think about this before you respond next time...
> 1. Since he would discontinue the SSRI at least SEVERAL DAYS previous to doing MDMA, this should be no special risk -- unless you have new info on the half lives of SSRIs. It is like MDMA alone.

Prozac's main metabolite (norfluoxetine, which is a potent SSRI) has a half-life of 9-14 days according to Lilly literature. Using the rule-of-thumb that one should wait 5 half-lives to ensure total elimination, Greg should wait , of, 5-6 weeks. With Zoloft it is 2 weeks. Etc.

> 2. Any SSRI that might remain (very minimal) also inhibits entry of MDMA into the neuron, and interferes with its release of serotonin.

The combo of MDMA & SSRI seems to be SSRI dependent. A quick literature search shows Proxac can (sometimes) potentiate MDMA effects, Zoloft negates it. But you are right, generally speaking, SSRi's do offer protection against Ecstasy. Or reduce its effects if protection is the wrong word.

> I find it curious you don't offer these warnings when people ask for information about SSRIs and MAOIs for example.

I haven't been asked. But if I were, I sure would offer the warning.

In general, this bulletin board is about depression, and the effectiveness of various palliative measures. As such, most people would, I think, naturally want to warn off someone like Greg from experimenting with MDMA. This warning results not from the prudish point of view, but from the standpoint of not further exacebating his depression (which is presumably why he is reading this BB in the first place). He wanted info on any dangers, he got info.


> Here's some true/false statements for Cindy:
> -- Marijuana causes aggression.
> -- LSD causes chromosone damage.
> -- This is your brain on drugs (eggs frying).
> -- The ends justify the means.
> The real danger of misinformation is that people learn to distrust the source -- in this case valid warnings also.




Post a new follow-up

Your message only Include above post

Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.


Start a new thread

Google www
Search options and examples
[amazon] for

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:Bruce thread:17636