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Re: Shortness of breath/ more info.

Posted by andrewb on December 8, 1999, at 11:21:19

In reply to Re: Shortness of breath, posted by andrewb on December 8, 1999, at 10:56:44

> Scott,

Here is an abstract of a study concerning serotonin, asthma and tianeptine:

Neuropharmacologic treatment of bronchial asthma with the antidepressant tianeptine: a double-blind, crossover placebo-controlled study
Lechin F, van der Dijs B, Orozco B, Jara H, Rada I, Lechin ME, Lechin AE
Section of Psychopharmacology,
Institute of Experimental Medicine,
Central University of Venezuela, Caracas.
Clin Pharmacol Ther 1998 Aug; 64(2):223-32


Studies have shown the levels of free serotonin in plasma are increased in symptomatic
patients with asthma. In addition, the concentration of free serotonin in symptomatic
children with asthma correlates positively with clinical status and negatively with
pulmonary function (forced expiratory volume in 1 second [FEV1]). Thus, reducing the
concentration of free serotonin in plasma may be useful in treating children with asthma. We
studied the effectiveness of tianeptine in treating these patients. Tianeptine is the only drug
known to be able to reduce the level of free serotonin in plasma and to enhance the uptake by
platelets. Sixty-nine of the 82 children with asthma initially enrolled participated in this
study. Children were randomized to receive tianeptine or placebo or both in a double-blind
crossover trial. The trial lasted 52 weeks. Tianeptine provoked a dramatic and sudden decrease
of both clinical rating and free serotonin plasma levels and an increase in pulmonary




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