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Re: Another Q for the Duck

Posted by Dysthymic Duck on November 13, 1999, at 7:14:39

In reply to Another Q for the Duck, posted by andrewb on November 1, 1999, at 11:24:49

Hi Andrewb. Sorry for the long delay. Had a
Crash a Burn last week.

Anyway, the 'brain-booster' med my doc uses
is an off the wall use of "thyrotrophin
releasing hormone" (TRH). I don't know your medical
backgound (i.e. a med student), so sorry if this
is pedantic to ya.

TRH is normally used to test the thryroid gland,
by injecting it (IV I imagine). The hormone is
naturally produced by the pituitary and when it
hits the thryroid, the thryoid starts making
thyroid hormones.

What my doc uses is dilute TRH intranasally and
as eyedrops. It's a way off the wall use. But
it works for me.

The theory is that there are receptors for TRH in nasal cavity,
on the trigeminal(sp?) nerve. The hypothesis is, that
stimulating this nerve sends signals back to
certain parts of the brain, and though a chain of
events cause the release of a lot of things, i.e.
dopamine, GABA, serotionin, and god knows
what else. Oh, and the reason for the eyedrops
is that the trigeminal nerve (a facial nerve)
splits into 3 parts, and goes to different
parts of the face and jaw (i.e. one inervates your

The only problem is, it's not quite enough. Trying
to supplement with Wellbutrin and Adderall, but
isn't working too well.

Thanks for the tip on amisulpide -- my doc lets me
try just about anything I ask for, so I'll talk to
him about it.

> What kind of medicines are you taking that are helping you with your cognitive problems? Concerning your anhedonia and dysthymia, an antidepressant called amisulpride may help. It has helped me. I think it may be especially effective with anhedonia. Side effects are uncommon. If you like more info. on the med. e-mail me at




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