Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Prozac plus Amisulpride

Posted by andrewb on August 29, 1999, at 13:20:36

In reply to Prozac plus Amisulpride, posted by jamie on August 27, 1999, at 15:54:01

> I have been on Prozac for months. It works on a lot of my depression but I still have no joy. I knew a change was coming so I am down to 10mg prozac now. I also have some 50mg tabs of amisulpride. I am wondering if anyone knows if I can take these together? I don't want to wait forever to stop the prozac. Maybe they would go good together? Prozac for serotonin? Amisupride for dopamine? Anyone know? Thank you in advance.

If I were in your shoes, I would stop the Prozac and allow a washout period before starting the amisulpride. I have a few reasons for saying this. First of all, Iíve never read of amisulpride, or amineptine for that matter, being mixed with an SSRI. This is uncharted territory. In addition, I have read that selegiline, a med. with dopaminergic action, may cause an adverse reaction (i.e. seretonin syndrome) when combined with SSRIs. When I was taking amineptine, a dopamine reuptake blocker, I once took s tablet of serzone, an SSRI. Within an hour of taking the Serzone, I started getting a reaction that included agitation and a racing heart (symptoms of seretonin syndrome?). It was a long, uncomfortable night.
Adam makes a good point about antipsychotics being able to be combined with SSRIs. But amisulpride is only an antipsychotic at high doses. Amisulpride is interesting in that its action at low doses is almost the opposite of its action at high doses. At high doses (400mgs. and up) it is a dopamine receptor antagonist, decreasing the activity of D2-D3 limbic receptors. At low doses however, it increases the activity of those receptors by acting on the presynaptic autoreceptors. Therefore at low doses, 50 to 100mgs., amisulpride is able to activate the D2-D3 limbic system dopaminergic pathways thought to be involved with mood, motivation, and anxiety.
I understand that you may have a tough period while your wiating for the Prozac to washout, but by taking amisulpride by itself, you will be able to better understand the medicineís action upon your body and what your ideal dosage may be. Hopefully, amisulpride will be the only medicine you need. Keep us posted on how you do, your experiences are valuable to others. Iím wishing you well. Remember, itís prudent to work under the guidance of a psychiatrist.




Post a new follow-up

Your message only Include above post

Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.


Start a new thread

Google www
Search options and examples
[amazon] for

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:andrewb thread:10724