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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by jamie on August 27, 1999, at 15:54:01
I have been on Prozac for months. It works on a lot of my depression but I still have no joy. I knew a change was coming so I am down to 10mg prozac now. I also have some 50mg tabs of amisulpride. I am wondering if anyone knows if I can take these together? I don't want to wait forever to stop the prozac. Maybe they would go good together? Prozac for serotonin? Amisupride for dopamine? Anyone know? Thank you in advance.
Posted by RG on August 28, 1999, at 11:44:02
In reply to Prozac plus Amisulpride, posted by jamie on August 27, 1999, at 15:54:01
> I have been on Prozac for months. It works on a lot of my depression but I still have no joy. I knew a change was coming so I am down to 10mg prozac now. I also have some 50mg tabs of amisulpride. I am wondering if anyone knows if I can take these together? I don't want to wait forever to stop the prozac. Maybe they would go good together? Prozac for serotonin? Amisupride for dopamine? Anyone know? Thank you in advance.
I am sure Andrew would give you an answer. A bunch of us are interested in this or Mirapex. I believe it is o.k. to mix both, but I am not a doctor and really have no sure answer. Please let me know how it works for you. Keep US Posted
Posted by Adam on August 28, 1999, at 13:17:53
In reply to Re: Prozac plus Amisulpride, posted by RG on August 28, 1999, at 11:44:02
I read that amisulpride is used in schizophrenia. It works on the negative symptoms. A lot of those are like depression and anhedonia. But I also read that schizophrenia drugs like amisulpride or other antipsychotics are combined with antidepressants sometimes. So it sounds like prozac and amisulpride would be OK, especially with lower doses to be safe. From previous posts I think the pharmacology goddess Elizabeth and amisulpride user Andrew might help. Let us know how it goes.
Posted by andrewb on August 29, 1999, at 13:20:36
In reply to Prozac plus Amisulpride, posted by jamie on August 27, 1999, at 15:54:01
> I have been on Prozac for months. It works on a lot of my depression but I still have no joy. I knew a change was coming so I am down to 10mg prozac now. I also have some 50mg tabs of amisulpride. I am wondering if anyone knows if I can take these together? I don't want to wait forever to stop the prozac. Maybe they would go good together? Prozac for serotonin? Amisupride for dopamine? Anyone know? Thank you in advance.
Jamie,
If I were in your shoes, I would stop the Prozac and allow a washout period before starting the amisulpride. I have a few reasons for saying this. First of all, I’ve never read of amisulpride, or amineptine for that matter, being mixed with an SSRI. This is uncharted territory. In addition, I have read that selegiline, a med. with dopaminergic action, may cause an adverse reaction (i.e. seretonin syndrome) when combined with SSRIs. When I was taking amineptine, a dopamine reuptake blocker, I once took s tablet of serzone, an SSRI. Within an hour of taking the Serzone, I started getting a reaction that included agitation and a racing heart (symptoms of seretonin syndrome?). It was a long, uncomfortable night.
Adam makes a good point about antipsychotics being able to be combined with SSRIs. But amisulpride is only an antipsychotic at high doses. Amisulpride is interesting in that its action at low doses is almost the opposite of its action at high doses. At high doses (400mgs. and up) it is a dopamine receptor antagonist, decreasing the activity of D2-D3 limbic receptors. At low doses however, it increases the activity of those receptors by acting on the presynaptic autoreceptors. Therefore at low doses, 50 to 100mgs., amisulpride is able to activate the D2-D3 limbic system dopaminergic pathways thought to be involved with mood, motivation, and anxiety.
I understand that you may have a tough period while your wiating for the Prozac to washout, but by taking amisulpride by itself, you will be able to better understand the medicine’s action upon your body and what your ideal dosage may be. Hopefully, amisulpride will be the only medicine you need. Keep us posted on how you do, your experiences are valuable to others. I’m wishing you well. Remember, it’s prudent to work under the guidance of a psychiatrist.
Posted by Adam on September 4, 1999, at 19:23:23
In reply to Re: Elizabeth? Andrew?, posted by Adam on August 28, 1999, at 13:17:53
I guess we got another Adam here :)
> I read that amisulpride is used in schizophrenia. It works on the negative symptoms. A lot of those are like depression and anhedonia. But I also read that schizophrenia drugs like amisulpride or other antipsychotics are combined with antidepressants sometimes. So it sounds like prozac and amisulpride would be OK, especially with lower doses to be safe. From previous posts I think the pharmacology goddess Elizabeth and amisulpride user Andrew might help. Let us know how it goes.
This is the end of the thread.
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