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Re: Dysthymia/Treatment Resistant Depressions

Posted by Andrew on April 13, 1999, at 16:12:03

In reply to Dysthymia/Treatment Resistant Depressions, posted by JohnB. on April 8, 1999, at 23:24:43

It would be interesting to hear the personal experiences of those using Amisulpride to treat their dysthymia.
I've taken Amineptine for dysthymia, a general dopamine reuptake blocker, at a small dose for about 3 months with good results. I've had for as long as I can remember low mood and lack of drive. I had tried both Serzone and Buproprion (Wellbutrin). Neither medicine improved my mood however. The Amineptine gently provides me with drive. It is as if it helps provide the energy that allows me to care about and enjoy life. That has been my experience anyway.
Amineptine has had the minor side effect (at 50 mg./day) of making patterns 'dance' sometimes before my eyes, such as the pattern on a carpet in a dark hallway. When I had tried it at a higher dose it made the colors of some objects glow. Also, my thoughts became scattered and I felt irritable. So I don't take a higher dose.
I wonder if Amisulpride, since it targets only the D2-D3 receptors, has less of these side effects?
I've read Pramipexole, used to treat Parkinsons, has been shown in early trials to be effective for depression. It is described as either a D3 agonist or a D2-D3 agonist. Does anyone have experience with this medicine?




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