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Re: Refractory depression--naltrexone theories?

Posted by Wayne R. on April 12, 1999, at 7:50:08

In reply to Re: Refractory depression--naltrexone theories?, posted by Jim on April 10, 1999, at 17:21:26

> Since naltrexone is an opiate antagonist that can also help with drug and alcohol cravings as well as impulse disorders (gambling, cutting, etc.), I'd reckon that some depressive states might also involve a counter-productive "addiciton" to the body's own opiate peptides. This addiction might be strong enough to keep somebody chronically depressed by the way the opiate system interacts with noradrenaline and especially dopamine, among other things…

Jim, I am just an interested patient and have no training in any of this. My question is why there would be no evidence of Naltrexone being an effective AD in its own right if this was the case? Everything I have seen points to it only being effective as an augmentation and even then only for the SSRI family. Wayne




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