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Re: paxil/ this as good as it gets?

Posted by Wayne R. on March 29, 1999, at 8:16:32

In reply to paxil/ this as good as it gets?, posted by Jan on March 29, 1999, at 6:51:02

> ... My depression has turned into apathy. I have no energy for anything and everything is an effort.

Jan, here is a posting from Dr Bob's Psychopharmacology Tips area. I responded well to Naltrexone as noted in this posting... Best wishes, Wayne

From: L. Dante
Date: Wed, 29 May 1996 01:04:25 -0400
Subject: SSRIs and apathy

I have been working with this phenomenon for quite a few years and lately have come to believe it to be what the pharmacologists call tachyphylaxis. At least half the time it can be reversed by adding naltrexone between 25 mg and 100 mg per day as tolerated and giving it two to four weeks to work. Results often include a better remission of the depressive symptoms than you ever got on the initial go round. I wonder if opiate interneurons in the RAS are the common system mediating the antidepressant effects of all the various meds we use.




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