Posted by DL on December 14, 1998, at 22:14:28
In reply to Re: Effexor, posted by Toby on December 14, 1998, at 10:48:33
> Effexor blocks serotonin and norepinephrin reuptake into the neuron (which keeps it in the synapse longer which lets it have more of an effect on the mood receptors). At low doses, it only blocks serotonin reuptake so it acts exactly like an SSRI (which is why it made you feel like the SSRI's did). At medium doses it blocks both serotonin and norepinephrine (and acts like a tricyclic antidepressant) and at very high doses it blocks monoamines like dopamine (so it acts like an MAOI and also like Wellbutrin). So it is a very complex drug and is many drugs in one, depending on the dose.
How is Remeron different from these AD's? Is the racy, nervous, jumping out of my skin feeling a normal/expected result of serotonin increase? Or are these side effects of some other mecanism triggered by the drugs? Because Remeron also is supposed to increase serotonin, but as I understand it, it also blocks one kind of serotonin receptor [therefore blocking entry to the receiving cell.]. Even Wellbutrin was very activating for the very short time I took it. Would I have had better results if I took large doses? I guess I don't understand why I had no increase in nervousness and internal shift into high gear if it also increases serotonin.
NOTE: I sent out letters to a number of the people on the EMDR list and hope to hear soon. It is hard to make such calls at work between home visits and it is too late when I get home. Hope I have some responses.
poster:DL
thread:1428
URL: http://www.dr-bob.org/babble/19981201/msgs/1585.html