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Posted by Hugh on March 6, 2019, at 11:17:49

Low-dose naltrexone (LDN) is used to treat some forms of cancer and some autoimmune diseases, such as MS, rheumatoid arthritis, ulcerative colitis, Crohn's, and lupus. Some people find it helpful for depression and bipolar disorder.

Naltrexone was approved by the FDA in 1984 to treat addictions to opioids and alcohol. Naltrexone tablets are 50 mg. LDN is usually taken in doses of 1.5 to 4.5 mg.

Taken at doses much lower than 1.5 mg, naltrexone could be even more effective as an antidepressant. Ultra-low-dose naltrexone (ULDN) doses are in the micrograms, nanograms, and even the picograms. At these extremely low doses, naltrexone activates the opioid receptors in the brain.

The following quote is from

"Cotreatment with ultra-low-dose naltrexone at 16.7, 20, or 25 ng/kg, but not at 10 or 200 ng/kg, induced a significant CPP after this 2-h delay. This finding implies that, whereas the rewarding effects of morphine have dissipated by 120 min postinjection, ultra-low-dose naltrexone may extend this effect."

In other words, an extremely low dose of naltrexone enhanced the effects of morphine, and prevented tolerance to it from developing. And it prevented dependence and addiction from developing. A higher, but still tiny, dose of naltrexone didn't have these beneficial effects.

Even if you're not taking opiates, you might benefit from taking ultra-low-dose naltrexone, since we all have naturally occurring opioids -- endorphins. An extremely low dose of naltrexone, taken every day, might improve your brain's response to your naturally occurring endorphins.

So if you aren't helped by 1.5 to 4.5 milligrams of naltrexone, try lowering your dose to micrograms. If that doesn't help, lower your dose to nanograms. If that doesn't help, lower it to picograms. Other than the naltrexone, all you need is distilled water to dilute it with and a calculator.

Naltrexone is water-soluble, so dissolve a 50-mg tablet in 50 ml of distilled water and use a medicine dropper to measure the dose. If refrigerated, liquid low-dose naltrexone will keep for several weeks.




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