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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by linkadge on April 20, 2007, at 17:51:18
Other than SJW, are there any herbs that inhibit the reuptake of norepinephrine that anyone knows of ??
Linkadge
Posted by nolvas on April 20, 2007, at 19:56:49
In reply to Any NRI herbs ?, posted by linkadge on April 20, 2007, at 17:51:18
Green Tea may prolong the actions of Norepinephrine (due to the Tea Polyphenols in Green Tea inhibiting the activity of Catechol-O-Methyltransferase (COMT), the enzyme that degrades Norepinephrine).
Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity. Int J Obes Relat Metab Disord. 24:252-258, 2000.
The thermogenic effect of tea is generally attributed to its caffeine content. The authors report that a green tea extract stimulates brown adipose tissue thermogenesis to an extent which is much greater than can be attributed to its caffeine content per se, and that its thermogenic properties could reside primarily in an interaction between its high content in green tea polyphenols and caffeine with sympathetically released noradrenaline (NA). Since green tea polyphenols are known to be capable of inhibiting catechol-O-methyl-transferase (the enzyme that degrades norepinephrine), and caffeine to inhibit trancellular phosphodiesterases (enzymes that break down norepinephrine-induced cAMP), it is proposed that the green tea extract, via its catechin-
polyphenols and caffeine, is effective in stimulating thermogenesis by relieving inhibition at different control points along the NA-cAMP axis. Such a synergistic interaction between catechin-
polyphenols and caffeine to augment and prolong sympathetic stimulation of thermogenesis could be of value in assisting the management of obesity.
Posted by Declan on April 20, 2007, at 22:15:49
In reply to Re: Any NRI herbs ?, posted by nolvas on April 20, 2007, at 19:56:49
Turmeric/curcumin also is a COMT inhibitor?
Posted by nolvas on April 21, 2007, at 3:18:10
In reply to Re: Any NRI herbs ?, posted by Declan on April 20, 2007, at 22:15:49
Quercetin has COMT and MAO inhibition properties.
"Quercetin, a flavonoid present in many plants, is reported to inhibit COMT and MAO activities, the key enzymes involved in the metabolism of dopamine."
Posted by linkadge on April 21, 2007, at 8:09:12
In reply to Re: Any NRI herbs ?, posted by nolvas on April 21, 2007, at 3:18:10
I know that theoretically it should make no difference, but I actually prefer the feeling of a NRI to that of a COMT inhibitor.
(at least that is from my limited experience with COMT inhibiting herbs vs. strattera)
Linkadge
Posted by Declan on April 21, 2007, at 16:28:40
In reply to Re: Any NRI herbs ?, posted by linkadge on April 21, 2007, at 8:09:12
Maybe there are no herbal NRIs?
I think resveratrol might be a COMT inhibitor too.
There's so many herbs that can contribute to wakefulness (which I guess is a different subject), among them such interesting herbs as Goji berries and Ashwaganda.
Posted by Declan on April 24, 2007, at 22:37:45
In reply to Any NRI herbs ?, posted by linkadge on April 20, 2007, at 17:51:18
There is oat straw extract, and green oat extract, and they may not be the same.
Apparently green oat extract is an inhibitor of MAO-B and PDE4, resulting in higher levels of dopamine and cAMP.
Hydergine and caffeine also lead to an increase in cAMP.
(I had a good response to Hydergine.)
This is the end of the thread.
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