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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by sdb on July 13, 2006, at 19:03:24
Whats actually the therapeutical difference between
pure inositol and inositolhexaphosphate? -These are the most sold products OTC.According to studies one should need up to 18g/day
of inositol. I suppose they used pure inositol in the studies.sdb,
"How can I teach somebody when I am learning all the time"
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Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder.
Palatnik A, Frolov K, Fux M, Benjamin J.
Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheba, Israel.
Only 70% of patients respond to current treatments for panic disorder, and many discontinue drugs because of side effects. myo-Inositol, a natural isomer of glucose and a precursor for the second-messenger phosphatidyl-inositol system, has previously been found superior to placebo in the treatment of depression, panic disorder, and obsessive-compulsive disorder (OCD), but a direct comparison with an established drug has never been performed. A double-blind, controlled, random-order crossover study was undertaken to compare the effect of inositol with that of fluvoxamine in panic disorder. Twenty patients completed 1 month of inositol up to 18 g/day and 1 month of fluvoxamine up to 150 mg/day. Improvements on Hamilton Rating Scale for Anxiety scores, agoraphobia scores, and Clinical Global Impressions Scale scores were similar for both treatments. In the first month, inositol reduced the number of panic attacks per week (mean and SD) by 4.0 (2) compared with a reduction of 2.4 (2) with fluvoxamine (p = 0.049). Nausea and tiredness were more common with fluvoxamine (p = 0.02 and p = 0.01, respectively). Because inositol is a natural compound with few known side effects, it is attractive to patients who are ambivalent about taking psychiatric medication. Continuing reports of inositol's efficacy in the treatment of depression, panic disorder, and OCD should stimulate replication studies.
Publication Types:
* Clinical Trial
* Randomized Controlled Trial
Am J Psychiatry. 1996 Sep;153(9):1219-21. Related Articles, LinksInositol treatment of obsessive-compulsive disorder.
Fux M, Levine J, Aviv A, Belmaker RH.
Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel.
OBJECTIVE: Earlier studies reported that inositol, a simple polyol second messenger precursor, was effective in controlled trials for patients with depression and panic. In this study its effectiveness in obsessive-compulsive disorder was investigated. METHOD: Thirteen patients with obsessive-compulsive disorder completed a double-blind, controlled crossover trial of 18 g/day of inositol or placebo for 6 weeks each. RESULTS: The subjects had significantly lower scores on the Yale-Brown Obsessive Compulsive Scale when taking inositol than when taking placebo. CONCLUSIONS: The authors conclude that inositol is effective in depression, panic, and obsessive-compulsive disorder, a spectrum of disorders responsive to selective serotonin reuptake inhibitors.
Publication Types:
* Clinical Trial
* Randomized Controlled Trial
PMID: 8780431 [PubMed - indexed for MEDLINE]
Posted by nolvas on July 13, 2006, at 20:02:41
In reply to diff. between inositol and inositolhexaphosphate?, posted by sdb on July 13, 2006, at 19:03:24
Inositol Hexaphosphate is also known as Phytic Acid or IP-6. Inositol Hexaphosphate is an organic Acid composed of one molecule of the Myoinositol form of Inositol joined with six Phosphorus molecules (i.e. it is the hexaphosphate ester of Inositol).
I can tell you that if you taste Inositol and Inositol Hexaphosphate you will know the difference. Inositol (it's like a sugar molecule)tastes sweet like sugar and Inositol Hexaphosphate tastes like earth or dirt.
I have been taking 12 -14 grams of Inositol a day to treat Agoraphobia and panic disorder. I started around May 31st and have consumed the amounts described above every day consistently. So I've been taking Inositol for about 5 -6 weeks, longer than any of the studies. I have noticed that the generalised anxiety has almost gone, some times it reoccurs like today for example (but I have been consuming alcohol and wheat products which I know I don't tolerate that well). Avoidance anxiety is still there, panic attacks well I haven't has as many. I think it's subtle you generally feel better but I don't believe it's anywhere near a cure for agoraphobia, it possibly makes you feel like you can tackle situations. I am going to persevere with it anyway. The only side effect I have noticed is feeling drowsy, but it's not a constant feeling.
I obtained the Inositol (1KG) from bulknutrition.com but I've found a UK supplier so I'm going to use them just as it's more convenient.
Posted by dessbee on July 14, 2006, at 5:36:43
In reply to Re: diff. between inositol and inositolhexaphosph, posted by nolvas on July 13, 2006, at 20:02:41
Does inositol have any anti-depressive effects?
Does it improve sleep?Who is your UK provider for Inositol (web address)?
How well do you tolerate caffeine (tea, coffee, coke) considering your anxiety disorder?
Posted by nolvas on July 14, 2006, at 6:13:57
In reply to Re: UK supplier » nolvas, posted by dessbee on July 14, 2006, at 5:36:43
I'm not a particulary depressed person. I once got extremely depressed in 1993 and that was horrible so I can empathasize with people who suffer continuous depression. But to answer the question I do think it has some anti depressive effect as my mood seems a bit brighter and I have fewer catastrophic thoughts.
Again Insomnia is not something I suffer from. All I can answer in regard to whether it helps with sleep is that I have noticed that I will feel quite drowsy for small periods at a time. So it's possible that it could help.
http://www.myprotein.co.uk/bulk-powders/health-and-wellness/inositol/
Put 1KG in your basket and you will see that you get a 25% discount making the price a very attractive £29.93. About £2-3 cheaper than buying from USA.
I don't tolerate caffeine whatsoever. It increases anxiety for me, especially when if I drink coffee. Strangely when I used to drink diet coke I used to think it improved my mood and I didn't feel especially anxious. I'm wondering if it was the phenylalanine content of the aspartame sweetener, but that is merely a guess. Anyway I make sure I don't dont consume any caffeine. I even drink decaf green tea. The natural L-Theanine in green tea is supposed to counteract the effects of caffeine but I still feel some effect, so that's why I choose to drink decaf green tea.
Posted by nolvas on July 14, 2006, at 6:27:29
In reply to diff. between inositol and inositolhexaphosphate?, posted by sdb on July 13, 2006, at 19:03:24
I've realised that I didn't answer the original question. What's the therapeutic difference between Inositol and IP6 (Inositol Hexaphosphate).
The difference is that where as Inositol has theraupeutic benefits for mental health, nervous system etc, there are none such benefits listed for IP6. IP6 main therapeutic benefit seems to be for the immune system and cardiovascular system.
I did see somewhere that combining IP6 with Inositol allows you to use less Inositol. However I've tried it in the past and didn't see any benefit from it. IP6 can also cause absorption problems for Calcium, Iron, Magnesium and Zinc.
Alcohol, Estrogens and Caffeine all interfere with Inositol.
Epi-inositol is reputedly more potent than Inositol. However it's been impossible for me to find and there is no reliable dosage information.
http://www.biopsychiatry.com/epi-inositol.htm
Posted by dessbee on July 14, 2006, at 7:02:11
In reply to Re: UK supplier, posted by nolvas on July 14, 2006, at 6:13:57
Thanks, I think I am going to try inositol in a lower doses.
Do you decaff green tea yourself or buy it?
Have you ever tried red tea (rooibos)? It should be free from caffeine and comes in many flavors.
It does not have any theanine but alot of bioflavinoids. What I have noticed is that it is stimulating although it is claimed to be caffeine free.
Posted by nolvas on July 14, 2006, at 7:14:00
In reply to Re: decaff green tea » nolvas, posted by dessbee on July 14, 2006, at 7:02:11
I buy Tetleys Decaf Green Tea when I'm in Morrisons supermarket, it's in a little round tub. It's not the best quality green tea and I don't know whether the decaf process negates some of the health benefits of the tea.
Earlier this month I tried Rooibos Red Tea, it's a pleasant tea and yeah I do seem to find it stimulating.
Posted by sdb on July 14, 2006, at 11:07:11
In reply to Re: diff. between inositol and inositolhexaphosph, posted by nolvas on July 14, 2006, at 6:27:29
>I've realised that I didn't answer the original >question
Thanks for the response.
I took yesterday maybe up to 2gm and it seemed to me that it has some relaxing properties. Something like a very smooth light benzodiazepine feeling. One dosage experience.
I am keen to find out more of pharmacological knowledge and experience of clinical usage for different diseases from the not classified vit. B substance.
Thanks for sharing every experience.
sdb
Posted by Meri-Tuuli on July 14, 2006, at 12:09:58
In reply to Re: decaff green tea, posted by nolvas on July 14, 2006, at 7:14:00
Hey Nolvas!
Hope you are doing alright??
I have a couple of queries for you...
Okay, so my nutritionist recommended I buy soya lectitin (sorry my spelling is off, but you know the stuff I mean!)
But I looked at a tub in Holland and Barretts, and well, its half insosital and choline. Now I don't know which version of insoitol is was, but thats alot of choline!! I might be my imagination but I think I find choline rather depressongenic.
But taking alot of insoitol...isn't that going to affect some balance of something or other? ie do you need choline as well???? I'm abit confused!
Any help would be much appreicated.
Kind regards
Meri
PS sorry the post is abit garbled and my spelling is off!!
Posted by nolvas on July 14, 2006, at 14:06:21
In reply to Re: decaff green tea, posted by Meri-Tuuli on July 14, 2006, at 12:09:58
The Inositol in Lecithin is Phosphatidylinositol.
Phosphatidylinositol is a combination of these substances:
EFA (essential fatty acids) + mono-unsaturated or saturated fatty acid + Mineral Acid + glycerol + myo-inositol the active form of Inositol.
http://www.unhinderedliving.com/inositol.html
The Inositol and Choline you refer to in Lecithin are actually Phospholipids and not the pure form of each substance. The amount of choline in Phosphatidylcholine is 10-13%.
Posted by dessbee on July 27, 2006, at 12:17:37
In reply to Re: decaff green tea, posted by nolvas on July 14, 2006, at 14:06:21
Seems like Inositol could be used for panic disorder, obsessive-compulsive disorder (OCD), bulimia nervosa, binge eating and/or depression.
Found this article on Inositol:
http://www.findarticles.com/p/articles/mi_m0ISW/is_255/ai_n6211958
Posted by dessbee on August 2, 2006, at 9:42:35
In reply to Re: decaff green tea, posted by nolvas on July 14, 2006, at 14:06:21
Do you know how much 1 ml of inositol weighs?
This is the end of the thread.
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