Psycho-Babble Medication Thread 1115707

Shown: posts 1 to 9 of 9. This is the beginning of the thread.

 

Microdoses of meds

Posted by jay2112 on July 1, 2021, at 13:00:39

I think some microdoses of meds have more theraputic benefit, for many, on mental health. I posted my experience above on the 'Amphetamine for Schizophrenia' thread. They are using microdoses of the 'recreational' drugs, like MDMA, and magic
shrooms and such. Here in Canada, you can buy them at 'unlicensed' cannabis shops. (They aren't really legal, but it seems the police turn a bit of a blind eye.) Also, as below, this is not just with 'psychedelic' drugs..but with mainstream prescribed meds.

So, I'd highly suggest trying microdoses of meds, and give it 2+ weeks or so. YMMV, etc....Here is some research..

https://en.wikipedia.org/wiki/Microdosing

"It is reported that 15 of the 20 largest pharmaceutical companies have now used microdosing in drug development, and the use of the technique has been provisionally endorsed by both the European Medicines Agency and the Food and Drug Administration. It was once expected that by 2010, human microdosing would have gained a secure foothold at the discovery-preclinical interface, driven by early measurement of candidate drug behavior in humans and by irrefutable economic arguments."

Jay

 

Re: Microdoses of meds

Posted by Lamdage22 on July 1, 2021, at 13:11:48

In reply to Microdoses of meds, posted by jay2112 on July 1, 2021, at 13:00:39

I found that 37.5 mg Venlafaxine gave me an effect. Sometimes less is more. Higher doses just gave me more side effects.

 

Re: Microdoses of meds

Posted by rjlockhart37 on July 3, 2021, at 2:26:24

In reply to Re: Microdoses of meds, posted by Lamdage22 on July 1, 2021, at 13:11:48

i've read 10mg of prozac helped people

 

Re: Microdoses of meds

Posted by Hugh on July 3, 2021, at 10:58:36

In reply to Microdoses of meds, posted by jay2112 on July 1, 2021, at 13:00:39

I've written here about low-dose naltrexone and ultra-low-dose naltrexone.

https://www.dr-bob.org/babble/alter/20180212/msgs/1103507.html

And I've written about microdosing phenytoin (Dilantin).

http://ww.dr-bob.org/babble/20190728/msgs/1106389.html

Some scientists believe that everyone should microdose lithium. I've been microdosing lithium orotate and lithium aspartate for years. I recently started microdosing ionic lithium chloride. I like this form the best.

http://www.dr-bob.org/babble/alter/20190907/msgs/1115445.html

 

Re: Microdoses of meds Hugh

Posted by jay2112 on July 3, 2021, at 19:36:55

In reply to Re: Microdoses of meds, posted by Hugh on July 3, 2021, at 10:58:36

Hi Hugh:

Thanks for pointing out those great posts! I am particularly interested in tiny doses of lithium, as my kidney dysfunction can't take even 150mg of lithium.

Keep trying...that's my motto, I guess. It seems to be a tension between the pull of depression, and the push of anxiety. Sucks though...when the years really go by, we have less time ahead, to find new wonders. Getting old just really sucks.
Jay :(

 

Re: Microdoses of meds jay2112

Posted by Hugh on July 5, 2021, at 10:41:33

In reply to Re: Microdoses of meds Hugh, posted by jay2112 on July 3, 2021, at 19:36:55

You're welcome, Jay. I find it fascinating that such tiny doses of lithium can have such profound effects.

I was just reading that EECP (enhanced external counterpulsation) can significantly improve kidney function by improving circulation. I'm interested in trying it, since it can help depression by improving circulation to the brain.

 

Re: Microdoses of meds Hugh

Posted by porkpiehat on July 23, 2021, at 20:29:42

In reply to Re: Microdoses of meds jay2112, posted by Hugh on July 5, 2021, at 10:41:33

> You're welcome, Jay. I find it fascinating that such tiny doses of lithium can have such profound effects.
>

What are you considering "microdoses" of lithium? Used for stabilization or just depression?

When I take 100mg of lithium I feel super dead inside


 

Re: Microdoses of meds porkpiehat

Posted by Hugh on July 26, 2021, at 13:06:27

In reply to Re: Microdoses of meds Hugh, posted by porkpiehat on July 23, 2021, at 20:29:42

> What are you considering "microdoses" of lithium? Used for stabilization or just depression?
>
> When I take 100mg of lithium I feel super dead inside

There are studies that indicate that people can benefit significantly from getting just a few hundred micrograms of lithium per day. Tiny doses can improve mood and longevity and help to prevent dementia.

 

Re: Microdoses of meds

Posted by PeterMartin on October 16, 2021, at 21:27:34

In reply to Re: Microdoses of meds porkpiehat, posted by Hugh on July 26, 2021, at 13:06:27

> > What are you considering "microdoses" of lithium? Used for stabilization or just depression?
> >
> > When I take 100mg of lithium I feel super dead inside
>
> There are studies that indicate that people can benefit significantly from getting just a few hundred micrograms of lithium per day. Tiny doses can improve mood and longevity and help to prevent dementia.
>

There is a company that is trying to bring a special micro-dose lithium pill, called NP03, to market for dementia/Alzheimer's. They had positive results in a recent trial, but I couldn't get information from them as to when it might be availalbe:

https://pubmed.ncbi.nlm.nih.gov/31868669/

NP03, a Microdose Lithium Formulation, Blunts Early Amyloid Post-Plaque Neuropathology in McGill-R-Thy1-APP Alzheimer-Like Transgenic Rats

Epidemiological, preclinical, and clinical studies have suggested a role for microdose lithium in reducing Alzheimer's disease (AD) risk by modulating key mechanisms associated with AD pathology. The novel microdose lithium formulation, NP03, has disease-modifying effects in the McGill-R-Thy1-APP transgenic rat model of AD-like amyloidosis at pre-plaque stages, before frank amyloid-β (Aβ) plaque deposition, during which Aβ is primarily intraneuronal. Here, we are interested in determining whether the positive effects of microdose lithium extend into early Aβ post-plaque stages. We administered NP03 (40μg Li/kg; 1 ml/kg body weight) to McGill-R-Thy1-APP transgenic rats for 12 weeks spanning the transition phase from plaque-free to plaque-bearing. The effect of NP03 on remote working memory was assessed using the novel object recognition task. Levels of human Aβ38, Aβ40, and Aβ42 as well as levels of pro-inflammatory mediators were measured in brain-extracts and plasma using electrochemiluminescent assays. Mature Aβ plaques were visualized with a thioflavin-S staining. Vesicular acetylcholine transporter (VAChT) bouton density and levels of chemokine (C-X-C motif) ligand 1 (CXCL1), interleukin-6 (IL-6), and 4-hydroxynonenal (4-HNE) were probed using quantitative immunohistochemistry. During the early Aβ post-plaque stage, we find that NP03 rescues functional deficits in object recognition, reduces loss of cholinergic boutons in the hippocampus, reduces levels of soluble and insoluble cortical Aβ42 and reduces hippocampal Aβ plaque number. In addition, NP03 reduces markers of neuroinflammation and cellular oxidative stress. Together these results indicate that microdose lithium NP03 is effective at later stages of amyloid pathology, after appearance of Aβ plaques.


This is the end of the thread.


Show another thread

URL of post in thread:


Psycho-Babble Medication | Extras | FAQ


[dr. bob] Dr. Bob is Robert Hsiung, MD, bob@dr-bob.org

Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.