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Dr. Bob is Robert Hsiung, MD,
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Posted by Escapee on September 24, 2016, at 10:57:19
In reply to Re: Nardil update. » Escapee, posted by SLS on September 24, 2016, at 9:27:27
Thanks! You make a lot of sense.
I am 'cushioned' somewhat by the bupropion and amitriptyline. Also the GABAergic effects of clonazepam plus whatever actions my pregabalin has.
But you are probably right that its best to keep dosing regular. I have found phenelzine pills to be somewhat hygroscopic. Easy fix that by keeping the half pill in a tub with a sprinkling of dry rice.
The pill coating is definitely hygroscopic. Melts in the mouth very quickly too. I love the taste! Possibly has some kinda placebo effect. That I have just put something good in in my mouth :)
Same with the smell.My urine retention has disappeared already. I will start adding 7.5mg Monday.
Escapee
Posted by Escapee on September 24, 2016, at 11:37:00
In reply to Re: Nardil update. » SLS, posted by Escapee on September 24, 2016, at 10:57:19
Found one site claiming Marplan to have a half life of about 36 hours!
http://www.mind.org.uk/information-support/drugs-and-treatments/antidepressants-a-z/isocarboxazid/Wiki shows nothing but a question mark lol.
When I 1st took Nardil, from what I recall Nardil's half-life was 2-3hrs! That was wiki. I'm sure RX list said the same. Maybe further studies proved that to be wrong. Or perhaps I am mistaken.
This is an interesting statement:
"The irreversible MAOIs are rapidly absorbed and generally quickly eliminated, with plasma elimination half-lives of 1.54 hours.35,43 However, because of their irreversible inhibition of MAO, the physiological effects of phenelzine, isocarboxazid, and tranylcypromine persist for up to 23 weeks.13 Thus, their pharmacodynamic half-life is greater than the pharmacokinetic half-life alone would suggest."
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075358/
Under the heading 'Drug Interactions'. Second paragraph.
Posted by SLS on September 24, 2016, at 13:56:42
In reply to Re: Nardil update., posted by Escapee on September 24, 2016, at 11:37:00
It is Parnate (tranylcypromine) that has the 2-3 hour half-life. Parnate goes in, some of which attaches to the MAO enzyme irreversibly (almost). The rest of it is quickly eliminated from the blood stream, but the "damage" to the enzymes have already been done.
Nardil (phenelzine) is a weird one. Despite its having a 12 hour half-life, it builds up in the brain exponentially as the dosage is increased linearly. This is because Nardil inhibits its own metabolism. It is broken down by MAO. Since it inhibits MAO, the rate of metabolism decreases with increasing dosage. This is important to consider when dosing. The difference between 45 mg/day to 60 mg/day yields a greater percentage jump in drug activity than the difference between 30 mg/day and 45 mg/day. For this reason, it is good practice to make dosage increases at a minimum of 3 week intervals - one week to gain sufficiently more MAO inhibition, and two more weeks to respond to it.
http://www.rxlist.com/nardil-drug/clinical-pharmacology.htm
It takes courage to go back on a drug that had forced you to use a catheter last time. That's not much fun - I know.
- Scott
Posted by Escapee on September 24, 2016, at 14:37:39
In reply to Re: Nardil update. » Escapee, posted by SLS on September 24, 2016, at 13:56:42
Thank you for the info.
My doctor did indeed want me to get to 45mg within a couple of weeks, but without compromising my side effect profile which he knows all too well.
I also have type 1 diabetes. So renal function is particularly important for me.
He said he wanted us to take things 'slowly'. I have to agree with him. I could be taking Nardil for the rest of my life. I'm fine with that so I am fine with taking things one stage at a time.
But tranylcypromine is still on the back burner. A safety net if you like.
Escapee
Posted by Escapee on September 25, 2016, at 4:15:01
In reply to Re: Nardil update. » SLS, posted by Escapee on September 24, 2016, at 14:37:39
I felt awful yesterday (Sat). I was in tears in the evening but for no aparent reason. OK so i am pissed about having to drop 15mg of Nardil as things were starting to happen at 45mg. I felt more confident, robust. So I guess it was chemical.
I took an 7.5mg dose last night. So thats 15mg morning, 15mg afternoon & 7.5mg at night. Good to keep it all spread out at least at 1st. When the side effects subside I should get away with taking the full dose between morning & late afternoon.
Last time I remember that the anxiety was relieved & confidence risen shortly after dosing. Perhaps the GABAergic effects increase with each dose, similar to a benzo? Idk. But I believe that if I bunch up the doses too close together right now I will have more severe side effects.
Its Sunday. Woke up early. Feel ok. Eye still killing. See what happens.
Posted by SLS on September 25, 2016, at 6:52:51
In reply to Re: Nardil update., posted by Escapee on September 25, 2016, at 4:15:01
> I felt awful yesterday (Sat). I was in tears in the evening but for no aparent reason. OK so i am pissed about having to drop 15mg of Nardil as things were starting to happen at 45mg. I felt more confident, robust. So I guess it was chemical.
>
> I took an 7.5mg dose last night. So thats 15mg morning, 15mg afternoon & 7.5mg at night. Good to keep it all spread out at least at 1st. When the side effects subside I should get away with taking the full dose between morning & late afternoon.
>
> Last time I remember that the anxiety was relieved & confidence risen shortly after dosing. Perhaps the GABAergic effects increase with each dose, similar to a benzo? Idk. But I believe that if I bunch up the doses too close together right now I will have more severe side effects.I am inclined to agree with you.
- Scott
Posted by Escapee on September 25, 2016, at 16:05:39
In reply to Re: Nardil update. » Escapee, posted by SLS on September 25, 2016, at 6:52:51
>>But I believe that if I bunch up the doses too close together right now I will have more severe side effects.
>
> I am inclined to agree with you.Actually I cant take this so I'm gonna add another 7.5mg to my morning dose as well. I was taking 30mg in the morn & 15mg in the afternoon, as directed by my doc. And I was actually feeling better with that. I started the gym, started going to support groups and made much needed appointments. Not exactly in a good mood but 'doing things'. And I had energy too without fatigue.
The social anxiety seemed to have been stumped out, at least partially. Negative thought looping had stopped. Felt less self conscious. Avoidance was loosing its power and procrastination had faded somewhat. I was even thinking about working again! 1st time in 11yrs.Right now I dont feel like doing any of the above. Seems I was on a roll and that hitting 60mg would have possibly pulled me right out of my hole! Hmm...
Still, I will do my best. I have a busy day tomorrow, if I actually succeed with my efforts and dont back out! Counselling assessment in the afternoon, group in the evening and the gym afterwards. Thats a lot for me! Gonna have to give myself a big push though.
The good news is that the 'mentioned' side effect has ceased. The water works are flowing freely again, with the help of some mild diuretics (Stinging Nettle extract & di-potassium phosphate) and drinking lots of water.
So to make things clear thats 22.5mg/morning, 15mg/afternoon and 7.5mg/night.
If said side effect does begin to show up I can take the 7.5mg off the morning or night dose instead of a whole 15mg. Sounds silly, but these tiny measurements are making the difference right now.
Escapee
Posted by J Kelly on September 26, 2016, at 8:16:04
In reply to Re: Nardil update. » SLS, posted by Escapee on September 25, 2016, at 16:05:39
Sounds like one side effect is out of the way :)
Btw- my pdoc made a point of telling me that doses should always be split up. That is, 15mg at a time. He says that "bunching" doses together is not as effective as splitting them up. Not sure if there's truth to that or not.
Hope you have a productive day!
Jade
Posted by Escapee on September 26, 2016, at 11:17:58
In reply to Re: Nardil update. » Escapee, posted by J Kelly on September 26, 2016, at 8:16:04
> Btw- my pdoc made a point of telling me that doses should always be split up. That is, 15mg at a time. He says that "bunching" doses together is not as effective as splitting them up. Not sure if there's truth to that or not.
Hi. Yes what your doc said does make sense. For some reason my doc wanted me to slowly work up to 30mg morning & 15mg lunch. Perhaps he wasn't aware of my previous side effects. Tho I never told him about them and it was 12yrs ago!
Posted by J Kelly on September 26, 2016, at 17:43:09
In reply to Re: Nardil update. » J Kelly, posted by Escapee on September 26, 2016, at 11:17:58
So what were your side effects 12 years ago? Why did you d/c it? How effective for you was it back then?
Jade
Posted by Escapee on September 26, 2016, at 20:15:37
In reply to Re: Nardil update. » Escapee, posted by J Kelly on September 26, 2016, at 8:16:04
> Btw- my pdoc made a point of telling me that doses should always be split up. That is, 15mg at a time. He says that "bunching" doses together is not as effective as splitting them up. Not sure if there's truth to that or not.
Thankyou jade. Thats exactly what I will do. 15/morn, 15/afternoon & 15/night.
Tho eventually I hope to be taking the full dose split between morning & Afternoon. From experience Nardil feels far more powerful that way!
Posted by J Kelly on September 27, 2016, at 9:02:34
In reply to Re: Nardil update. » Escapee, posted by J Kelly on September 26, 2016, at 17:43:09
> So what were your side effects 12 years ago? Why did you d/c it? How effective for you was it back then?
>
> JadeHi Escapee,
Did you miss this post? Just curious :)
Jade
Posted by Escapee on September 28, 2016, at 8:29:33
In reply to Re: Nardil update., posted by J Kelly on September 27, 2016, at 9:02:34
Feeling flat despite back up to 45mg, 15mg thrice daily. Maybe after a couple of days I will feel optimistic again. Ideally want to be taking 30mg in the morning. I'm sure that would make more difference. It did before. Last time I took Nardil I never took a nightly dose. Seems like a waste as the effects seem most potent after each dose. I dont really need its effects as much while I'm asleep! Not just that, my doc wrote 30mg morn & 15mg afternoon. Probably so there is less clash with the amitriptyline which I also take at night.
My side effect isn't too bad. Still getting urges without substance. But am really flushing my system with water laced with the diuretics dipotassium phosphate, nettle extract and vit C, which also seems to have diuretic & laxative effects at 3g thrice daily. I'm just about able to 'go' twice daily.
Posted by Escapee on September 28, 2016, at 9:10:40
In reply to Re: Nardil update., posted by J Kelly on September 27, 2016, at 9:02:34
> > So what were your side effects 12 years ago? Why did you d/c it? How effective for you was it back then?
> >
> > Jade
>
> Hi Escapee,
>
> Did you miss this post? Just curious :)
>
> Jade
>
>When I started Nardil back in December 2003. I was living in a 'dry' house with 9 other people. I was the only one who never spoke and kept myself to myself and shut myself in my room most of the time.
I noticed something almost strait away on just 15mg. Only a mild calming effect, nothing else. But I did not feel any chemical sensation I've felt from most other meds. The feeling that its in your bloodstream, even if there is not yet any positive or negative effects.
As I increased the dose I slowly became less troubled, more sociable yet still without 'noticing' or 'feeling' any effects I could put down to Nardil. I just didn't make the connection.
After almost 4 weeks and being on 45mg for about a week I had started to 'feel' different. Urges to socialise but without having any outlet to do so. Positive mood too. So despite being directed to stay on 45mg until my next appointment I felt compelled to hit 60mg. So I did.
Within a day I had a 'light switch' effect! Felt fantastic! My negative thought feedback loop had disappeared. I become much less self conscious & my mood was great! Strait away I began to 'crave' company and began going to my local SA group. Made a couple of friends within a group I felt happy to be part of. Even my talking changed. Pronunciation became important to me. I couldn't help but wear a smile and I began actively creating social interactions. Meetings for coffee. Walks. Cinema.
Within a month after that the urine retention started. I waited and waited for it to go but eventually I took myself to A&E and had a catheter fitted. Yet I felt so good I wasn't too bothered about it. Not even the procedure bothered me! After 4-5 weeks the catheter was taken out and all was fine.
Within the next few months I had my 1st ever internet line fitted and was sharing online. Started to chat online too. Found myself a girlfriend and began visiting her, travelling via train. And she would visit me too. We took turns.
By June I had found myself a job (1st since I was 17, in 1997), found myself an apartment and moved out of the dry house without any help from anyone whatsoever. I was living independently for the 1st time in my life.
By the end of 2004 I was sharing a large flat with my girlfriend and worked in a steady job.
So there ya go :)
Escapee
Posted by Escapee on September 28, 2016, at 9:28:33
In reply to Re: Nardil update., posted by J Kelly on September 27, 2016, at 9:02:34
> > Why did you d/c it?
> >
I ditched it cos it seemed to become less effective and I got fed up with the unsuccessful augmentations, plus I wanted to give Marplan a blast. Little did I know how much it was still helping me until it was too late. It was still helping more than I thought. I just had really bad hypersomnia. Lost a good job too (my last job) while withdrawing from it.
Posted by Escapee on September 28, 2016, at 16:06:49
In reply to Re: Nardil update. » J Kelly, posted by Escapee on September 28, 2016, at 9:28:33
I feel just totally ruined. whats going on
Posted by Escapee on September 28, 2016, at 16:28:03
In reply to Re: Nardil update., posted by Escapee on September 28, 2016, at 16:06:49
60 is becoming very tempting right now
Posted by SLS on September 28, 2016, at 16:31:31
In reply to Re: Nardil update., posted by Escapee on September 28, 2016, at 8:29:33
I think that it is a mistake to judge Nardil based on a few days at a given dosage. It can take weeks. Also, there is something about Nardil that can be stimulating immediately after taking each dose. Don't interpret this as an indicator of how you should adjust your dosage. It is tempting, I know. You want to feel as good as you can as quickly as you can.I would continue to divide your dosage. It might reduce side effects. Do you get insomnia with Nardil? Have you stopped dreaming yet?
- Scott
Posted by SLS on September 28, 2016, at 16:48:00
In reply to Re: Nardil update., posted by Escapee on September 28, 2016, at 16:28:03
> 60 is becoming very tempting right now
I know it is. However, I don't recommend that you raise the dosage so quickly. Allow time for your system to acclimate itself to 45 mg/day first. You don't want to trigger urinary retention again. In fact, given your history, I would consider going up to 52.5 mg/day for a week or two. As I have mentioned before, the degree of MAO inhibition is not linear relative to dosage. It is exponential. You won't know what side effects will emerge for at least a week after increasing the dosage. Then, it might take another 2-3 weeks to obtain a therapeutic response. You won't get anywhere if you aren't more patient. I have wasted a lot of time being impatient and playing with dosages.
- Scott
Posted by Escapee on September 28, 2016, at 16:49:00
In reply to Re: Nardil update. » Escapee, posted by SLS on September 28, 2016, at 16:31:31
> I think that it is a mistake to judge Nardil based on a few days at a given dosage. It can take weeks. Also, there is something about Nardil that can be stimulating immediately after taking each dose. Don't interpret this as an indicator of how you should adjust your dosage. It is tempting, I know. You want to feel as good as you can as quickly as you can.I would continue to divide your dosage. It might reduce side effects. Do you get insomnia with Nardil? Have you stopped dreaming yet?
>
>
> - ScottTaking 15mg at night seems to give me a headache. I think taking at the same time as my amitriptyline isn't helping.
I'm going to stop taking a few supplements I've added in the last month. L-theanine, Maca & mega-doses of B3. I dont think the large doses of vit C (10g daily) is the problem, but I'm gonna stop that too.Just want to also say that I am not a child. I make good decisions with my medications. My illness is the main culprit. And by going by my history staying on 45mg seems a waste of time.
I rarely dream as my amitriptyline has sorted that problem out long ago, esp taken with quetiapine.
And my doc directed me to take 30mg am and 15mg noon. He isn't stupid he did that for a reason im sure. Said side effect is becoming less important to me now and I'm about to count my pills and see when I can go to 60 without running out.
Thanks anyway.
Posted by J Kelly on September 28, 2016, at 16:51:33
In reply to Re: Nardil update., posted by Escapee on September 28, 2016, at 16:06:49
> I feel just totally ruined. whats going on
Shoot! Are you avoiding 60mg cause of your urinary problem? Or are there other reasons/side effects? I'm at 60mg and haven't yet benefited from it. In addition I'm feeling very anxious. So I guess we both have to remain patient!
Jade
Posted by Escapee on September 28, 2016, at 16:51:34
In reply to Re: Nardil update. » Escapee, posted by SLS on September 28, 2016, at 16:48:00
> > 60 is becoming very tempting right now
>
> I know it is. However, I don't recommend that you raise the dosage so quickly. Allow time for your system to acclimate itself to 45 mg/day first. You don't want to trigger urinary retention again. In fact, given your history, I would consider going up to 52.5 mg/day for a week or two. As I have mentioned before, the degree of MAO inhibition is not linear relative to dosage. It is exponential. You won't know what side effects will emerge for at least a week after increasing the dosage. Then, it might take another 2-3 weeks to obtain a therapeutic response. You won't get anywhere if you aren't more patient. I have wasted a lot of time being impatient and playing with dosages.
>
>
> - ScottEND OF THREAD
Posted by SLS on September 28, 2016, at 17:06:33
In reply to Re: Nardil update., posted by Escapee on September 28, 2016, at 16:51:34
> > > 60 is becoming very tempting right now
> >
> > I know it is. However, I don't recommend that you raise the dosage so quickly. Allow time for your system to acclimate itself to 45 mg/day first. You don't want to trigger urinary retention again. In fact, given your history, I would consider going up to 52.5 mg/day for a week or two. As I have mentioned before, the degree of MAO inhibition is not linear relative to dosage. It is exponential. You won't know what side effects will emerge for at least a week after increasing the dosage. Then, it might take another 2-3 weeks to obtain a therapeutic response. You won't get anywhere if you aren't more patient. I have wasted a lot of time being impatient and playing with dosages.
> >
> >
> > - Scott
>
> END OF THREADI don't understand your anger. What did I say that upset you?
- Scott
Posted by Escapee on September 28, 2016, at 17:24:41
In reply to Re: Nardil update. » Escapee, posted by SLS on September 28, 2016, at 17:06:33
stop trying to be a doc!
Posted by SLS on September 28, 2016, at 17:42:52
In reply to Re: Nardil update. » SLS, posted by Escapee on September 28, 2016, at 17:24:41
> stop trying to be a doc!
I thought I was offering education and support. Maybe I didn't do a very good job of it.
I was an adult when I made some very bad decisions. I have seen doctors who have made some very bad decisions. I think it was you who described going up and down and up again in dosage because of urinary retention being an intolerable side effect. I was attempting to convey to you information that I learned through education and personal experience.
- Scott
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