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Re: Nardil update.

Posted by Escapee on September 24, 2016, at 11:37:00

In reply to Re: Nardil update. SLS, posted by Escapee on September 24, 2016, at 10:57:19

Found one site claiming Marplan to have a half life of about 36 hours!
http://www.mind.org.uk/information-support/drugs-and-treatments/antidepressants-a-z/isocarboxazid/

Wiki shows nothing but a question mark lol.

When I 1st took Nardil, from what I recall Nardil's half-life was 2-3hrs! That was wiki. I'm sure RX list said the same. Maybe further studies proved that to be wrong. Or perhaps I am mistaken.

This is an interesting statement:

"The irreversible MAOIs are rapidly absorbed and generally quickly eliminated, with plasma elimination half-lives of 1.54 hours.35,43 However, because of their irreversible inhibition of MAO, the physiological effects of phenelzine, isocarboxazid, and tranylcypromine persist for up to 23 weeks.13 Thus, their pharmacodynamic half-life is greater than the pharmacokinetic half-life alone would suggest."

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075358/

Under the heading 'Drug Interactions'. Second paragraph.


Amitriptyline 100mg
Bupropion(Wellbutrin/Zyban)300mg
Quetiapine(Seroquel)150mg
Clonazepam(Klonopin/Rivotril)3mg
Pregabalin(Lyrica)400mg
Phenelzine(Nardil)45mg


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poster:Escapee thread:1091031
URL: http://www.dr-bob.org/babble/20160819/msgs/1092351.html