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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by SLS on February 18, 2016, at 10:14:16
Norepinephrine = Noredrenaline
"Vulnerability to Depression Linked to Noradrenaline"
"McGill University News, 02/17/2016
Firstever connection between noradrenergic neurons and vulnerability to depression.
The team of Bruno Giros, a researcher at the Douglas Mental Health University Institute and professor of psychiatry at McGill University, reports the firstever connection between noradrenergic neurons and vulnerability to depression. Published in the journal Nature Neuroscience, this breakthrough paves the way for new depression treatments that target the adrenergic system. We know that a small cerebral structure, known as the ventral tegmental area, contains dopaminergic neurons that play a key role in vulnerability to depression, explains Bruno Giros, whose team is part of the CIUSSS de lOuestdelÎledeMontréal research network. By mimicking stressful life events in animal models, the researchers confirmed that increased dopaminergic neuron activity corresponds to depression. Their research further shows that a second type of neuron, noradrenergic neurons, controls dopaminergic neuron activity. It is this control that steers the bodys response toward resilience or toward vulnerability to depression, says Giros. By combining pharmacological, genetic and optogenetic (activation of the neurons activity by a light beam) approaches, Giross team showed that animals that cannot release noradrenaline are systematically vulnerable to depression following chronic stress. This is not, however, an irreversible condition: increasing noradrenaline production results in higher resilience and less depression."
- Scott
Posted by Phillipa on February 18, 2016, at 18:26:10
In reply to What's old is new again - Back to norepinephrine!, posted by SLS on February 18, 2016, at 10:14:16
Just a follow up and some of the meds for some that may not know. Phillipa
http://mentalhealthdaily.com/2014/05/08/low-norepinephrine-and-depression-is-there-a-link/
Posted by rjlockhart37 on February 19, 2016, at 0:00:29
In reply to Re: What's old is new again - Back to norepinephrine! » SLS, posted by Phillipa on February 18, 2016, at 18:26:10
i think norepinephrine is a key factor in wakefulness and being alert, low factors of it make things seems sluggy and slow
Like Prozac i don't think would help much because it mainly increasess serotonin but it does increase NE at higher doses but it's not classified as a SNRI
Effexor and Wellbutrin and TCA's are known to increase NE alot
r
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