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What's old is new again - Back to norepinephrine!

Posted by SLS on February 18, 2016, at 10:14:16

Norepinephrine = Noredrenaline

"Vulnerability to Depression Linked to Noradrenaline"

http://www.mdlinx.com/neurology/medical-news-article/2016/02/17/6543662?utm_source=in-house-msg&utm_medium=message&utm_campaign=headlines-feb16

"McGill University News, 02/17/2016

Firstever connection between noradrenergic neurons and vulnerability to depression.
The team of Bruno Giros, a researcher at the Douglas Mental Health University Institute and professor of psychiatry at McGill University, reports the firstever connection between noradrenergic neurons and vulnerability to depression. Published in the journal Nature Neuroscience, this breakthrough paves the way for new depression treatments that target the adrenergic system. We know that a small cerebral structure, known as the ventral tegmental area, contains dopaminergic neurons that play a key role in vulnerability to depression, explains Bruno Giros, whose team is part of the CIUSSS de lOuestdelÎledeMontréal research network. By mimicking stressful life events in animal models, the researchers confirmed that increased dopaminergic neuron activity corresponds to depression. Their research further shows that a second type of neuron, noradrenergic neurons, controls dopaminergic neuron activity. It is this control that steers the bodys response toward resilience or toward vulnerability to depression, says Giros. By combining pharmacological, genetic and optogenetic (activation of the neurons activity by a light beam) approaches, Giross team showed that animals that cannot release noradrenaline are systematically vulnerable to depression following chronic stress. This is not, however, an irreversible condition: increasing noradrenaline production results in higher resilience and less depression."


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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poster:SLS thread:1086255
URL: http://www.dr-bob.org/babble/20160131/msgs/1086255.html