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Dr. Bob is Robert Hsiung, MD,
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Posted by Lamdage22 on January 30, 2016, at 10:53:11
In reply to Re: Intranasal NRX-1074 or intravenous (self)injection, posted by bk2va23 on January 30, 2016, at 10:51:44
Well they claim its NRX-1074. I will try to have it tested by another company.
Posted by swim on January 30, 2016, at 11:24:46
In reply to Intranasal NRX-1074 or intravenous (self)injection, posted by Lamdage22 on January 30, 2016, at 6:55:42
i must admit, i have attempted intravenous administration of ketamine based on instructions i found on youtube but wasn't able to pull it through because i got sick in the middle of the procedure, IM (intramuscular) was easy and painless though.
If at all possible I would advise you to find somebody to help on the IV, it really isnt as simple as it looks, if you mess up, it might end like a scene from The Texas Chainsaw Massacre..
Anyways, how did you obtain it, was it a group-buy? If not a secrete how much does it cost? Good luck, it has worked for many!
Posted by Lamdage22 on January 30, 2016, at 11:32:30
In reply to Re: Intranasal NRX-1074 or intravenous (self)injection, posted by swim on January 30, 2016, at 11:24:46
I have someone that will help with the injection (if intranasal fails). It wasnt a group buy and its not here yet.
It cost about $380 for 100mg.
Thanks:)
> i must admit, i have attempted intravenous administration of ketamine based on instructions i found on youtube but wasn't able to pull it through because i got sick in the middle of the procedure, IM (intramuscular) was easy and painless though.
> If at all possible I would advise you to find somebody to help on the IV, it really isnt as simple as it looks, if you mess up, it might end like a scene from The Texas Chainsaw Massacre..
> Anyways, how did you obtain it, was it a group-buy? If not a secrete how much does it cost? Good luck, it has worked for many!
Posted by Lamdage22 on January 30, 2016, at 11:34:59
In reply to Re: Intranasal NRX-1074 or intravenous (self)injection, posted by swim on January 30, 2016, at 11:24:46
> if you mess up, it might end like a scene from The Texas Chainsaw Massacre..
Why would i mess up? You mean when there is air in the syringe?Or if i use an artery?
Any other ways to mess up?
Posted by swim on January 30, 2016, at 12:08:43
In reply to Re: Intranasal NRX-1074 or intravenous (self)injection, posted by Lamdage22 on January 30, 2016, at 11:34:59
ok, let me explain what went wrong: at first i missed the vein couple of times, then i hit it but the needle came off, pricking myself further with the my new equipment trying to get some results i ended up spraying the blood all over the place loosing the shot of K in the process...
Posted by Lamdage22 on January 30, 2016, at 12:11:35
In reply to Re: Intranasal NRX-1074 or intravenous (self)injection, posted by swim on January 30, 2016, at 12:08:43
I will have a friend do it.
Posted by Lamdage22 on January 30, 2016, at 12:25:18
In reply to Re: Intranasal NRX-1074 or intravenous (self)injection, posted by Lamdage22 on January 30, 2016, at 12:11:35
I have to use 10ml of bac water to make the solution. Thats 0.9% sodium chloride, 1% benzylalcohol and 98.1% water.
Hmm it all has to be sterile right?
IDK where to get these things yet.
Posted by Lamdage22 on January 30, 2016, at 12:32:49
In reply to Re: Intranasal NRX-1074 or intravenous (self)injection, posted by Lamdage22 on January 30, 2016, at 12:25:18
Ok i get it at the pharmacy.
I am ready to do this. And i am kind of praying it will help.
Posted by swim on January 30, 2016, at 13:14:45
In reply to Re: Intranasal NRX-1074 or intravenous (self)injection, posted by Lamdage22 on January 30, 2016, at 12:32:49
i got the stuff for my Ketamine experiment from a local pharmacy . It's good you have a friend helping with the procedures, hope he/she has done it before, i'v heard it takes some practice. IM injections were really simple so i thought it would be a piece of cake for the IV, but it was not.. good luck and may the force be with you..
always
Posted by SLS on January 30, 2016, at 13:43:01
In reply to Re: Intranasal NRX-1074 or intravenous (self)injection, posted by Lamdage22 on January 30, 2016, at 12:32:49
Hi Lamdage.
I am having a difficult time with ethics and am concerned with your safety. I won't recommend to you what to do, but I can suggest to you what not to do.
Do not inject it IV. IV drips are necessary to administer these drugs properly. Precision in dosing is critical. Obviously, taking too little won't work. However, taking too much won't work either, even if you remain conscious. There is a narrow therapeutic window that produces results. If you experience unconsciousness or severe dissociation, you've gone too far.
The same rules of dosing apply to intranasal administration as in IV administration. Snorting powder will not deliver the exact amounts necessary to stay in the "zone". My ketamine was prescribed as a liquid to inhale. The concentration was measured with precision. The squirts produced by the spray bottle were also measured with precision as part of the bottle mechanism.
I have no opinion regarding IM injections.
If you want to move forward with your experiment, I think you should find out more about dosing and feel confident in the authenticity of the product. Since NRX-1074 is more potent than ketamine, there are no guidelines to dosing. For the sake of comparison, IV ketamine is drip of 0.5mg/kg delivered over 40 minutes.
Sorry...
- Scott
Posted by SLS on January 30, 2016, at 13:50:46
In reply to Re: Intranasal NRX-1074 or intravenous (self)injection, posted by Lamdage22 on January 30, 2016, at 12:32:49
I accidentally clicked on "Confirm", and posted before I was done editing.
Those guidelines were for ketamine. I wanted to emphasize that dose was important. Forget everything I said.
* I forgot that one of the main advantages to NRX-1074 is that it can be taken orally. Why aren't you administering it that way?
- Scott
Posted by Lamdage22 on January 30, 2016, at 14:37:04
In reply to Re: Intranasal NRX-1074 or intravenous (self)injection » Lamdage22, posted by SLS on January 30, 2016, at 13:43:01
Hi Scott,
it isnt really active orally. The dose would have to be like 500 or 700 mg and they dont even know if that works.
I bought 100mg. Two 50mg vials. I have to put 10ml bac water in each of them so that makes 5mg/ml. I would inject a half ml, then 1ml and then 2 ml.Couple days apart.
Posted by Lamdage22 on January 30, 2016, at 14:42:07
In reply to Re: Intranasal NRX-1074 or intravenous injection, posted by Lamdage22 on January 30, 2016, at 14:37:04
The product will be checked by a reputable company to make sure its NRX-1074.
Do you think the dosage stays the same for snorting as for the IV injection? I could put it in a nasal spray container.
What do you think about what i am doing??
I am pretty despaired you know.
Posted by SLS on January 30, 2016, at 15:12:35
In reply to Re: Intranasal NRX-1074 or intravenous injection, posted by Lamdage22 on January 30, 2016, at 14:42:07
From everything I've read, NRX-1074 is an orally active compound. It is worth taking a second look at the literature before shooting-up. Maybe you can find some documentation of the amounts they are experimenting with.
https://www.google.com/?gws_rd=ssl#q=NRX-1074+orally
- Scott
Posted by Lamdage22 on January 30, 2016, at 15:17:19
In reply to Re: Intranasal NRX-1074 or intravenous injection, posted by Lamdage22 on January 30, 2016, at 14:42:07
https://clinicaltrials.gov/ct2/results?term=nrx-1074&Search=Search
Check out the dosages. thats like $$$.
And i havent heard or read that its successful either.
Posted by Lamdage22 on January 30, 2016, at 15:28:39
In reply to Re: Intranasal NRX-1074 or intravenous injection, posted by Lamdage22 on January 30, 2016, at 15:17:19
I just read that NRX-1074 effects last only 3 days. Is this accurate?
Thats a downer!
Posted by SLS on January 30, 2016, at 15:41:14
In reply to Re: Intranasal NRX-1074 or intravenous injection, posted by Lamdage22 on January 30, 2016, at 14:42:07
> What do you think about what i am doing??
I am concerned.
I really can't take a position that would allow me to advise you for or against continuing with your experiment. What if I persuaded you to discontinue a drug that would have worked for you and given you your life back? God would kick my *ss. What if I encouraged you to go ahead with your experiment and you died. God would kick my *ss, and I could never live with myself.
> I am pretty despaired you know.
I know you are. I am very understanding of this from personal experience. Desperation has caused me to screw around with my medication quite a few times. Twice, I ended up in the hospital. One of my experiments produced a very dangerous episode of serotonin syndrome. Thankfully, I used a very small amount of the offending drug, which I chose because it had a short half-life. I felt that I had to know. Nothing else was working.
Sometimes, I lose respect for the power of drugs to produce profound biological effects. Desperation can cause one to make decisions on impulse, especially where pain is involved.
Please be careful.
- Scott
Posted by SLS on January 30, 2016, at 15:51:06
In reply to Re: Intranasal NRX-1074 or intravenous injection, posted by Lamdage22 on January 30, 2016, at 15:28:39
> I just read that NRX-1074 effects last only 3 days. Is this accurate?
I don't know. That's why ketamine is used on a regular schedule to maintain the therapeutic effect. A single infusion does not last for very long. A friend of mine is able to maintain remission by dosing once every 5 days with intranasal ketamine.
I'm sorry that you are disappointed at the moment. You'll persevere when you gather your energy. You are still very young and have a lot of drive to work with. It amazes me that you were able to get a hold of NRX-1074. I don't know how you did it!
- Scott
Posted by Lamdage22 on January 30, 2016, at 16:11:10
In reply to Re: Intranasal NRX-1074 or intravenous injection » Lamdage22, posted by SLS on January 30, 2016, at 15:51:06
But why would i die?
What speaks agsinst intranasal?
Posted by SLS on January 30, 2016, at 17:47:17
In reply to Re: Intranasal NRX-1074 or intravenous injection, posted by Lamdage22 on January 30, 2016, at 16:11:10
> But why would i die?
I don't know that you would.
> What speaks agsinst intranasal?
How will you know:
1. The authenticity of the substance you are about to put into your body?
2. How much you are supposed to take?
3. How to measure the amount to be taken?
4. What are the signs of toxicity?I believe that NRX-1074 is more potent than ketamine and GLYX-13.
I can't speak for you or anyone else, but I would not experiment with any of these drugs with the lack of facts and resources that you have available.
If you proceed, you should probably have someone in the room with you.
I don't like it.
- Scott
Posted by Lamdage22 on January 31, 2016, at 10:30:25
In reply to Re: Intranasal NRX-1074 or intravenous injection » Lamdage22, posted by SLS on January 30, 2016, at 17:47:17
> > But why would i die?
>
> I don't know that you would.
>
> > What speaks agsinst intranasal?
>
> How will you know:
>
> 1. The authenticity of the substance you are about to put into your body?I will have it tested by another company.
> 2. How much you are supposed to take?#
For intranasal i dont know. Injection: 10mg.
> 3. How to measure the amount to be taken?
For injection in a syringe. It is 5mg/ml.
> 4. What are the signs of toxicity?
There shouldnt be any as they have used it in trials with 10mg.
>
> I believe that NRX-1074 is more potent than ketamine and GLYX-13.
>
> I can't speak for you or anyone else, but I would not experiment with any of these drugs with the lack of facts and resources that you have available.
>
> If you proceed, you should probably have someone in the room with you.
>
> I don't like it.
>
>
> - Scott
>
Posted by Larry Hoover on February 4, 2016, at 12:11:09
In reply to Re: Intranasal NRX-1074 or intravenous injection, posted by Lamdage22 on January 31, 2016, at 10:30:25
I admire your willingness to push the envelope, but I share Scott's concerns about your jump to 10 mg IV injection of this investigational drug.
The Phase 2 clinical trial includes doses of 1 and 5 mg, but you have selected the highest dose, 10 mg.
https://clinicaltrials.gov/ct2/show/study/NCT02067793?view=record
Moreover, and as Scott has cautioned, you can be sure that the clinical trial will use an IV drip, not a bolus injection.
If you have obtained 100 mg of this drug, you're not faced with an all-or-nothing opportunity.
I'd like you to consider titrating your dose based on your response. Why not begin with 1 or 2 mg?
And I'd very much like to recommend to you that you go IM with whatever dose it is that you have selected. Even with someone present, you are not going to be medically supervised, as you certainly would be if you were in a clinical trial.
If you don't control the risk factors, you may well discover that the risk factors control you.
Regards,
Lar
Posted by SLS on February 4, 2016, at 13:39:20
In reply to Re: Intranasal NRX-1074 or intravenous injection, posted by Lamdage22 on January 31, 2016, at 10:30:25
Lamdage,
Another reason to titrate the dosage of NRX-1074 gradually is that it has yet to be determined if it has a therapeutic window as does ketamine. There might be a "zone" that one needs to stay within for it to work. Ketamine doesn't work if you take too much. (With ketamine, this probably has to do with its biphasic effect on AMPA glutamate activity at different concentrations). This might be one of the reasons why the Naurex clinical trial provided for several study arms using dosages ranging from 1-10 mg IV. Among other things, it is a dosage-finding study. For all we know, 1 mg might be more effective than 5 mg.
Personally, I would consider trying to have NRX-1074 compounded and prepared for intranasal administration. This should allow for more precise dosing. Ketamine works very well intranasally. Of course, I don't know for sure if NRX-1074 can be delivered this way. If the drug is found to be safe and effective when delivered intravenously, the next step might be to have it administered orally, which is the ultimate goal in marketing it. There are still many questions yet to be answered regarding NRX-1074.
You are tremendously resourceful. How will you go about preparing a solution from the powder for precise dosing?
Is there a toxic level of NRX-1074? This stuff is more potent than GLYX-13 (Rapastinel) based upon binding affinity to the glycine site of the NMDA receptor.
I am optimistic about this drug, however, I am still very concerned. Please don't hurt yourself. Be methodical and patient.
- Scott
Posted by Lamdage22 on February 4, 2016, at 14:14:25
In reply to Re: Intranasal NRX-1074 or intravenous injection » Lamdage22, posted by SLS on February 4, 2016, at 13:39:20
i will wait for others to try it. Longecity is doing a group buy. Soon we will know more.
I am not snorting or injecting unless somebody else has done so with no harm.
The solution is simple. Bac water 0,9% sodium chloride 1% benzylalcohol.
I hope the guys from longecity will be safe. If they dont get effects from nasal administration maybe they will do IV.
Posted by SLS on February 4, 2016, at 15:51:43
In reply to Re: Intranasal NRX-1074 or intravenous injection, posted by Lamdage22 on February 4, 2016, at 14:14:25
> i will wait for others to try it. Longecity is doing a group buy. Soon we will know more.
>
> I am not snorting or injecting unless somebody else has done so with no harm.
>
> The solution is simple. Bac water 0,9% sodium chloride 1% benzylalcohol.
>
> I hope the guys from longecity will be safe. If they dont get effects from nasal administration maybe they will do IV.Very logical.
:-)
- Scott
This is the end of the thread.
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