Posted by SLS on February 4, 2016, at 13:39:20
In reply to Re: Intranasal NRX-1074 or intravenous injection, posted by Lamdage22 on January 31, 2016, at 10:30:25
Lamdage,
Another reason to titrate the dosage of NRX-1074 gradually is that it has yet to be determined if it has a therapeutic window as does ketamine. There might be a "zone" that one needs to stay within for it to work. Ketamine doesn't work if you take too much. (With ketamine, this probably has to do with its biphasic effect on AMPA glutamate activity at different concentrations). This might be one of the reasons why the Naurex clinical trial provided for several study arms using dosages ranging from 1-10 mg IV. Among other things, it is a dosage-finding study. For all we know, 1 mg might be more effective than 5 mg.
Personally, I would consider trying to have NRX-1074 compounded and prepared for intranasal administration. This should allow for more precise dosing. Ketamine works very well intranasally. Of course, I don't know for sure if NRX-1074 can be delivered this way. If the drug is found to be safe and effective when delivered intravenously, the next step might be to have it administered orally, which is the ultimate goal in marketing it. There are still many questions yet to be answered regarding NRX-1074.
You are tremendously resourceful. How will you go about preparing a solution from the powder for precise dosing?
Is there a toxic level of NRX-1074? This stuff is more potent than GLYX-13 (Rapastinel) based upon binding affinity to the glycine site of the NMDA receptor.
I am optimistic about this drug, however, I am still very concerned. Please don't hurt yourself. Be methodical and patient.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1085796
URL: http://www.dr-bob.org/babble/20160131/msgs/1085939.html