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Dr. Bob is Robert Hsiung, MD,
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Posted by Chinaboy on October 8, 2014, at 8:49:28
I'd been taking Abilify at low dose for a while and found that it caused severe OCD-like symptoms to me! I suspect that the was due to its partial D2 agonist mechanism making D2 increased. Is my assumption correct?
And similarly meds with potential to increase D2 are likely to induce OCD? Like Amisulrpride at low dose, dopamine agonists such as selegiline, etc?
And from that, can I say meds blocking part of the D2 help reduce some of the OCD-like symptoms?
Welcome your input!
Posted by Christ_empowered on October 8, 2014, at 9:53:58
In reply to OCD induced by increased D2?, posted by Chinaboy on October 8, 2014, at 8:49:28
From what little I know, OCD is tricky and treatment is kind of hit or miss.
Atypicals (and older AP drugs) can make OCD worse.
Stimulants help some people, don't help others.
SRI drugs and some TCAs are fairly standard and reasonably effective.
Posted by linkadge on October 9, 2014, at 14:29:54
In reply to Re: OCD induced by increased D2?, posted by Christ_empowered on October 8, 2014, at 9:53:58
Some of the research suggests an abundance of dopaminergic neurotransmission relative to serotonergic neurotransmission in OCD.
Dopamine antagonists can augment SSRis for certain cases of OCD.
That being said, agents which block serotonin receptors (namely 5-ht2a/c) can sometimes worsen OCD.
On a theoretical bases, a typical antipsychotic might be a better augment of SSRIs for OCD.
Abilify can be activating for some individuals. This might increase OCD indirectly.
Linkadge
Posted by Chinaboy on October 13, 2014, at 3:54:49
In reply to Re: OCD induced by increased D2?, posted by Christ_empowered on October 8, 2014, at 9:53:58
Thank you for taking the time to answer my question!
I think I should avoid understanding each medicine mechanizm of action, and my neverending investigation into these difficult questions is just my symptom of OCD!
It's so severe that I really have no idea regarding what to do with it!
Posted by phidippus on October 20, 2014, at 20:21:33
In reply to OCD induced by increased D2?, posted by Chinaboy on October 8, 2014, at 8:49:28
Any kind of dopamine enhancement can cause OCD like symptoms.
However, dextroamphetamine has been shown to lessen OCD symptoms and it enhances dopamine transmission.
Go figure.
Eric
This is the end of the thread.
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