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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by g_g_gunit on May 18, 2013, at 12:52:46
hey Scott,
Hope you're still doing well on your current regimen ..
I just had a couple of questions re: minocycline ..
do you believe it has the potential to show anti-depressant efficacy when NOT used in conjunction with lamitrogine (as I believe there's some synergistic effect that's been alluded to)? I am currently taking 40mg of Parnate.
secondly, do you believe it's had a positive/negative/neutral effect on your anxiety?
FWIW, I'm interested in the glutamate-modulating properties as a potential target for OCD. The other anecdotal success I've read about re: OCD and antibiotics has been with the use of Augmentin, though there are no clinical trials backing up its use, outside of PANDAS-inflicted OCD. However, Augmentin likewise seems to have glumatate-modulating properties. I was more interested in monocycline, however, given the robust results it seems to be showing as an AD. There is currently a pilot trial recruiting participants for the study of monocycline in OCD.
Posted by SLS on May 18, 2013, at 17:35:41
In reply to question for SLS re: minocycline, posted by g_g_gunit on May 18, 2013, at 12:52:46
> hey Scott,
>
> Hope you're still doing well on your current regimen ..Tanx.
:-)
> I just had a couple of questions re: minocycline ..
>
> do you believe it has the potential to show anti-depressant efficacy when NOT used in conjunction with lamitrogineYes. Minocyline does a bunch of stuff besides reducing glutamate activity. It is hard to know what properties are important in the treatment of depression. Besides, its antiglutamatergic properties are substantial at multiple sites, even in the absence of lamotrigine. For OCD, one might speculate that combining memantine with minocycline would have a synergistic effect.
I am not familiar with any psychotropic effects that Augmentin might have. The cool thing is that minocycline is used to treat Lyme Disease. So, if that is a concern of yours, you would be attacking your condition(s) from multiple angles.
- Scott
Posted by Phillipa on May 18, 2013, at 18:41:18
In reply to Re: question for SLS re: minocycline » g_g_gunit, posted by SLS on May 18, 2013, at 17:35:41
Biaxin xl was good for lymes. Also despite it's long side effect list didn't experience any of the side effects. For me it was great. Phillipa
Posted by Phillipa on May 18, 2013, at 18:58:41
In reply to Re: question for SLS re: minocycline, posted by Phillipa on May 18, 2013, at 18:41:18
Infection control doc does believe I lost taste & smell due to the biaxin.
Posted by g_g_g_unit on May 19, 2013, at 6:45:59
In reply to Re: question for SLS re: minocycline » g_g_gunit, posted by SLS on May 18, 2013, at 17:35:41
> >
> > do you believe it has the potential to show anti-depressant efficacy when NOT used in conjunction with lamitrogine
>
> Yes. Minocyline does a bunch of stuff besides reducing glutamate activity. It is hard to know what properties are important in the treatment of depression. Besides, its antiglutamatergic properties are substantial at multiple sites, even in the absence of lamotrigine. For OCD, one might speculate that combining memantine with minocycline would have a synergistic effect.
>
> I am not familiar with any psychotropic effects that Augmentin might have. The cool thing is that minocycline is used to treat Lyme Disease. So, if that is a concern of yours, you would be attacking your condition(s) from multiple angles.
>Thanks for your response. I've found a GP who's willing to trial an antiobiotic. One paper I came across suggested Augmentin has similar glutamate-modulating properties, but perhaps Minocycline would be a better place to start given its proven efficacy in treating depression.
Just one other point you may have missed in my original post - has Minocycline had any impact (beneficial or otherwise) on your anxiety, pending that's a fact of your condition?
Posted by SLS on May 19, 2013, at 7:07:26
In reply to Re: question for SLS re: minocycline, posted by g_g_g_unit on May 19, 2013, at 6:45:59
>
> > >
> > > do you believe it has the potential to show anti-depressant efficacy when NOT used in conjunction with lamitrogine
> >
> > Yes. Minocyline does a bunch of stuff besides reducing glutamate activity. It is hard to know what properties are important in the treatment of depression. Besides, its antiglutamatergic properties are substantial at multiple sites, even in the absence of lamotrigine. For OCD, one might speculate that combining memantine with minocycline would have a synergistic effect.
> >
> > I am not familiar with any psychotropic effects that Augmentin might have. The cool thing is that minocycline is used to treat Lyme Disease. So, if that is a concern of yours, you would be attacking your condition(s) from multiple angles.
> >
>
> Thanks for your response. I've found a GP who's willing to trial an antiobiotic. One paper I came across suggested Augmentin has similar glutamate-modulating properties, but perhaps Minocycline would be a better place to start given its proven efficacy in treating depression.
>
> Just one other point you may have missed in my original post - has Minocycline had any impact (beneficial or otherwise) on your anxiety, pending that's a fact of your condition?I don't know whether or not minocycline works as an anxiolytic. I wouldn't be able to tell. I have taken care of the bulk of my anxiety through CBT and desensitization. My social anxiety used to be paralyzing. I would not characterize minocyclne as being pro-social as is Nardil. I'm sure you are aware that anxiety can be a feature of depression, even in the absence of an anxiety disorder. In those days when my social anxiety was still substantial, it would totally evaporate when I responded to tricyclics or MAOIs.
MI really sucks.
I hope you find something soon.
- Scott
Posted by g_g_g_unit on May 19, 2013, at 7:19:23
In reply to Re: question for SLS re: minocycline » g_g_g_unit, posted by SLS on May 19, 2013, at 7:07:26
>
> I don't know whether or not minocycline works as an anxiolytic. I wouldn't be able to tell. I have taken care of the bulk of my anxiety through CBT and desensitization. My social anxiety used to be paralyzing. I would not characterize minocyclne as being pro-social as is Nardil. I'm sure you are aware that anxiety can be a feature of depression, even in the absence of an anxiety disorder. In those days when my social anxiety was still substantial, it would totally evaporate when I responded to tricyclics or MAOIs.
>
> MI really sucks.
>
> I hope you find something soon.
>
>
> - ScottThanks so much, Scott. I appreciate your support. I'm currently working with a psychopharmacologist who's willing to push Parnate to higher doses, which is quite rare in Australia. 60mg was wonderful for depression, but did little for anxiety -- I've heard it can take on a different properties 80mg+, so I'm hopeful.
Posted by jono_in_adelaide on May 19, 2013, at 22:00:34
In reply to Re: question for SLS re: minocycline » SLS, posted by g_g_g_unit on May 19, 2013, at 7:19:23
If you're loking for a drug that kills strep (I gathered thats somehow part of the antibiotics/OCD story?) then minocycline isnt a good choice, over half of group a strep is now resistant - Penicillin V or Amoxcycillin would make more sense for this
Posted by g_g_g_unit on May 19, 2013, at 23:36:03
In reply to Re: question for SLS re: minocycline, posted by jono_in_adelaide on May 19, 2013, at 22:00:34
No, I don't believe I have strep. I'm looking for a drug that modulates glutamate (Minocycline is being trialed for OCD as we speak), plus there seems to be a host of other sexy benefits to taking Mino.
Posted by g_g_g_unit on May 20, 2013, at 8:06:50
In reply to Re: question for SLS re: minocycline » jono_in_adelaide, posted by g_g_g_unit on May 19, 2013, at 23:36:03
My GP doesn't like Augmentin, so ended up prescribing Minocycline. I've seen suggestions on here that it can be quite activating at first. I'm already feeling a little overstimulated on Parnate, so questioning whether I should start the Minocycline now ..
Did you find Mino activating at first?
Posted by SLS on May 20, 2013, at 21:19:31
In reply to SLS again, posted by g_g_g_unit on May 20, 2013, at 8:06:50
> My GP doesn't like Augmentin, so ended up prescribing Minocycline. I've seen suggestions on here that it can be quite activating at first. I'm already feeling a little overstimulated on Parnate, so questioning whether I should start the Minocycline now ..
>
> Did you find Mino activating at first?
Not really. However, I know someone who had to cut back on the dosage at first because of activation. This dissipated, though. I started at 100 mg/day. Perhaps you could try taking 50 mg in the morning for a few days. 200 mg/day is the optimum dosage for me.
- Scott
This is the end of the thread.
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