![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 22 of 22. This is the beginning of the thread.
Posted by Lamdage22 on December 4, 2012, at 5:14:34
Is Marplan weight neutral? I dont want to give up the GABA-T inhibitory effects of Nardil and believe, that Marplan has them, too.
Now i dont know if Marplan is weight neutral already?
Or should i switch to Parnate? I could get Parnate for free, Marplan, id have to pay for, since its not marketed in germany.
Also, i have Zyprexa for "Emergency" anti-manic/psychotic. Is there an equally efficient alternative with less weight gain side effects?
Thanks.
Sincerely,Julian
Posted by SLS on December 4, 2012, at 6:45:40
In reply to Nardil too much weight gain. -) Marplan?, posted by Lamdage22 on December 4, 2012, at 5:14:34
> Is Marplan weight neutral? I dont want to give up the GABA-T inhibitory effects of Nardil and believe, that Marplan has them, too.
I don't think that Marplan inhibits GABA-transaminase activity (and thus raise GABA levels) in the brain like Nardil does, even though both drugs are hydrazines.
> Now i dont know if Marplan is weight neutral already?
I found that Marplan was relatively weight-neutral when compared to Nardil.
> Or should i switch to Parnate?
What condition or symptoms are you attempting to treat?
I would say that a higher percentage of people respond to Parnate than to Marplan. Parnate is probably less liable than Nardil to precipitate mania, but it certainly can. I found Marplan to be very tolerable with respect to side-effects.
> Also, i have Zyprexa for "Emergency" anti-manic/psychotic.
If you are bipolar, it might be desirable to take some type of anti-manic or mood-stabilizer on a steady basis. It sounds like you are either bipolar I or schizoaffective. Of the neuroleptic antipsychotics, only Geodon and Latuda are truly weight-neutral. I think that Latuda would be safer to add to an MAOI than Geodon because Geodon inhibits the reuptake of serotonin like SSRIs do. I would be concerned that Geodon might precipitate serotonin syndrome, even though the drug is not terribly potent as a reuptake inhibitor. Latuda is currently being looked at for bipolar depression. Among the anticonvulsants, I would look at Trileptal and Depakote as providing protection against mania. Of course, lithium is a valid alternative. Depakote and lithium can, but not always, produce weight gain. I never gained weight with either of these drugs.
Good luck with whatever you choose.
- Scott
Posted by jono_in_adelaide on December 4, 2012, at 16:57:28
In reply to Nardil too much weight gain. -) Marplan?, posted by Lamdage22 on December 4, 2012, at 5:14:34
Marplan doesnt have Nardils effect on GABA-T unfortunatly
Posted by Lamdage22 on December 5, 2012, at 2:19:47
In reply to Re: Nardil too much weight gain. -) Marplan? » Lamdage22, posted by SLS on December 4, 2012, at 6:45:40
@ Jono
I believe that is why it is more weight neutral than nardil.
@ Scott:
Yes schizoaffective is what ive been called before. The problem is: Latuda is not available in germany, only geodon.
I think with the switch to Parnate (i have almost decided), i will be able to deal with a higher dose of seroquel.
One question: My pdoc suggested amisulpride. Would amisulpride be a better more weight neutral "emergency AP" option than zyprexa? I hear it is a very potent d2/d3 antagonist.
Sincerely,
Julian
Posted by Lamdage22 on December 5, 2012, at 2:27:22
In reply to Re: Nardil too much weight gain. -) Marplan?, posted by Lamdage22 on December 5, 2012, at 2:19:47
Posted by SLS on December 5, 2012, at 7:18:22
In reply to Due to candida, i refuse all weight gain meds (nm), posted by Lamdage22 on December 5, 2012, at 2:27:22
Of course, that is a personal decision. However, I am not convinced that every drug that produces weight gain also increases blood glucose.
- Scott
Posted by Lamdage22 on December 5, 2012, at 17:10:29
In reply to Re: Due to candida, i refuse all weight gain meds » Lamdage22, posted by SLS on December 5, 2012, at 7:18:22
Well they do all produce carb cravings though right?
Im tired of administering tons of willpower to stay halfway slim.Maybe with the change from Nardil to Parnate i will have some more room for weight gainy meds.
> Of course, that is a personal decision. However, I am not convinced that every drug that produces weight gain also increases blood glucose.
>
>
> - Scott
Posted by Lamdage22 on December 5, 2012, at 17:21:14
In reply to Re: Due to candida, i refuse all weight gain meds, posted by Lamdage22 on December 5, 2012, at 17:10:29
Posted by ed_uk2010 on December 7, 2012, at 13:50:48
In reply to Re: Nardil too much weight gain. -) Marplan?, posted by Lamdage22 on December 5, 2012, at 2:19:47
>My pdoc suggested amisulpride. Would amisulpride be a better more weight neutral "emergency AP" option than zyprexa?
Yes, amisulpride causes less weight gain than Zyprexa.
Posted by SLS on December 7, 2012, at 16:07:35
In reply to Re: Nardil too much weight gain. -) Marplan? » Lamdage22, posted by ed_uk2010 on December 7, 2012, at 13:50:48
> >My pdoc suggested amisulpride. Would amisulpride be a better more weight neutral "emergency AP" option than zyprexa?
>
> Yes, amisulpride causes less weight gain than Zyprexa.How often do you see amisulpride prescribed? Do you know what it is being prescribed for?
- Scott
Posted by ed_uk2010 on December 8, 2012, at 16:42:46
In reply to Re: Nardil too much weight gain. -) Marplan? » ed_uk2010, posted by SLS on December 7, 2012, at 16:07:35
>How often do you see amisulpride prescribed?
Quite often Scott.
>Do you know what it is being prescribed for?
Schizophrenia, sometimes with clozapine.
Posted by Cee on December 8, 2012, at 17:55:54
In reply to Re: Nardil too much weight gain. -) Marplan? » SLS, posted by ed_uk2010 on December 8, 2012, at 16:42:46
I am in my third week of Nardil at 90 mg how long does it take for a response
God bless
See
Posted by SLS on December 8, 2012, at 22:24:38
In reply to Re: Nardil response, posted by Cee on December 8, 2012, at 17:55:54
> I am in my third week of Nardil at 90 mg how long does it take for a response
> God bless
> SeeIf you don't see any improvement by the end of week 4 at 90 mg/day, you should probably make changes to your treatment regime.
What ideas have you been presented with by your doctor?
- Scott
Posted by Lamdage22 on December 11, 2012, at 16:46:43
In reply to Re: Nardil response » Cee, posted by SLS on December 8, 2012, at 22:24:38
Ok, im trying to organize my threads better in an attempt to get more responses than by just throwing disorganized questions at you guys.
Question on Parnate dosing:
On Nardil, i was on a lower dose 60mg as means of side effect management(sexual and overeating basically). If it wasnt for the side effects i would be on 90mg or more.
On what Parnate dosage should i go? How high up can one go with Parnate in order to get a better response? Do i even have to worry about any side effects with Parnate? Are the dietary restrictions stricter with Parnate e.g. a hypertensive crisis more likely to happen?On the Antipsychotics:
My plan right now is to switch from Pipamperon to Melperon, both oldschool APs but favorable side effect profiles, both are happily prescriped for sleep. Pipamperon is a low-potency AP, Melperon a medium potency AP. According to a pdoc its both relatively weight neutral. Then id add Geodon ontop of that.Question on Geodon dosage:
What is a dosage that doesnt affect the heart as much and is still effective? What do you recommend, also looking at the fact that its a mild snri and that i take an MAOI?
(Am i totally wrong here or is Parnate less Serotonergic than Nardil anyway?)I will also get a hold of some Latuda here, although its real expensive and german insurance doesnt want to cover it. Its too expensive for daily use, but not for as needed. I wanna have the non-weight-gainy APs ready. Zyprexa is out for sure.. that stuff is shoveling me an early grave with those eating habits.
This is what a person taking these drugs would have side effects wise.
This is a list of drugs that someone takes.bupropion
clomiphene
oxandrolone
Cytomel (liothyronine)
Geodon (ziprasidone)
Latuda (lurasidone)
Nolvadex (tamoxifen)
Parnate (tranylcypromine)Now i dont comment three of these meds, lets just say someone wants to do something for his borderline obese body over the course of two month. It will be a big byebye to any fat gained from meds and a welcome to some freakin MUSCLE.
I will prolly kick out the Bupropion when i take Parnate instead of Nardil anyway! ?? So i could forget about the interactions with wellbutrin.For the time on Nolvadex, Geodon will be replaced with Latuda.
Please check and provide me with knowledge input.
Sincerly,
Julian
Posted by Lamdage22 on December 13, 2012, at 17:27:19
In reply to Will certainly change to Parnate and NO more Zypr., posted by Lamdage22 on December 11, 2012, at 16:46:43
Get up and go:
Parnate 20mg
Liothyroxine 60mgCome down and get knocked out:
Geodon 40mg
Agomelatine 25mg
Melperone 50mg.5 Xanax as needed.
Wanna increase the Parnate.
And: EXERCISE
Posted by Lamdage22 on December 13, 2012, at 17:30:32
In reply to Visited Doc. He approved of my new med schedule:, posted by Lamdage22 on December 13, 2012, at 17:27:19
I hear Geodon can change something in the heart called QT Interval increase.
Anyone with experiences/studys/hearsay anecdotes wether its ok or not?
I feel Geodon could be the killer for me mentally and for my weight. Its a 5ht1A agonist?? Come on!
Posted by Lamdage22 on December 15, 2012, at 0:35:51
In reply to Geodon and Exercise? Cause for concern, posted by Lamdage22 on December 13, 2012, at 17:30:32
I know im not the only one person struggling and i come up with lots of questions, but can anyone answer?
Julian
Posted by SLS on December 15, 2012, at 8:33:28
In reply to My posts get overlooked?, posted by Lamdage22 on December 15, 2012, at 0:35:51
Hi Julian.
I don't think you are being ignored. Who knows why people choose to answer some posts and not others. I am limiting my time here more recently, so I don't participate in every thread. I'm sorry that you haven't received any replies for the last few of your posts. Be patient.
What is you most pressing need today?
- Scott
Posted by Lamdage22 on December 15, 2012, at 9:58:01
In reply to Re: My posts get overlooked? » Lamdage22, posted by SLS on December 15, 2012, at 8:33:28
Hi Scott, thanks for your reply.
I am angered about that "bipolar" diagnosis. I recieved my medical records from a hospital.
They are criminally insane what they wrote. Names written wrong, telling me im a psychopath... very objective hard facts 90% wrong, but FOR SURE their subjective view on my diagnosis is right. but in the hospital everyone was extra nice.What if its true, that i am a psychopath?
Plus my mother pisses me off. "No one can make it right for you". She can, she just doesnt give a sh*t to do that..
Because they say that, it becomes true.
I think Geodon is making me eat, too. I think i will see how i do with pipamperon and melperon.
Posted by Lamdage22 on December 15, 2012, at 9:59:45
In reply to Re: My posts get overlooked?, posted by Lamdage22 on December 15, 2012, at 9:58:01
A woman in that hospital, a psychologist said "i will report you, you little m*th*rf*ck*r" into my back.
Report me for what!??
Posted by Lamdage22 on December 15, 2012, at 10:17:14
In reply to Re: My posts get overlooked? » Lamdage22, posted by SLS on December 15, 2012, at 8:33:28
> Hi Julian.
>
> I don't think you are being ignored. Who knows why people choose to answer some posts and not others. I am limiting my time here more recently, so I don't participate in every thread. I'm sorry that you haven't received any replies for the last few of your posts. Be patient.
>
> What is you most pressing need today?
>
>
> - ScottI will limit my time here, too.
Posted by Lamdage22 on December 15, 2012, at 12:41:08
In reply to Re: My posts get overlooked?, posted by Lamdage22 on December 15, 2012, at 9:59:45
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.