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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by SLS on August 23, 2012, at 20:02:07
Vortioxetine is currently in Phase III. I like the way this drug looks.
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"Dual mechanism of action
Vortioxetine displays two complementary mechanisms of action in vitro: inhibition of serotonin reuptake and modulation of serotonin receptor activity. In addition to blocking the serotonin transporter protein, vortioxetine acts as antagonist at 5-HT3 and 5-HT7 receptors, a partial agonist at 5-HT1B receptors and an agonist at 5-HT1A."
http://www.mims.co.uk/news/1132799/new-multimodal-antidepressant-effective-elderly/
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"Vortioxetine (previously known as Lu AA21004) is under investigation as a multimodal anti-depressant that is thought to work through a combination of two complementary mechanisms of action: receptor activity modulation and reuptake inhibition. In vitro studies indicate that vortioxetine is a 5-HT3 and 5-HT7 receptor antagonist, 5-HT1B receptor partial agonist, 5-HT1A receptor agonist and inhibitor of the serotonin transporter (SERT). In vivo non-clinical studies have demonstrated that vortioxetine modulates neuronal firing and neurotransmitter release in multiple systems, resulting in enhanced levels of serotonin, noradrenaline, dopamine, acetylcholine and histamine in specific areas of the brain.
The multimodal activity profile of vortioxetine may translate into therapeutic benefits in depression that current therapies do not sufficiently address."
http://investor.lundbeck.com/pipeline.cfm
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- Scott
Posted by jono_in_adelaide on August 23, 2012, at 20:44:31
In reply to Vortioxetine: A new antidepressant?, posted by SLS on August 23, 2012, at 20:02:07
anything new is a good sign - it might those who are beyone help currently.
Posted by Phillipa on August 23, 2012, at 23:44:05
In reply to Re: Vortioxetine: A new antidepressant?, posted by jono_in_adelaide on August 23, 2012, at 20:44:31
Histimine anti-inflammatory? Phillipa
Posted by SLS on August 24, 2012, at 1:31:43
In reply to Re: Vortioxetine: A new antidepressant?, posted by jono_in_adelaide on August 23, 2012, at 20:44:31
> anything new is a good sign - it might those who are beyone help currently.
Yes. This one took me by surprise. I hadn't heard of it before today. Perhaps its most novel property as an antidepressant is serotonin 5-HT7 receptor antagonism.
- Scott
Posted by SLS on August 24, 2012, at 6:39:43
In reply to Vortioxetine: A new antidepressant?, posted by SLS on August 23, 2012, at 20:02:07
> Vortioxetine is currently in Phase III. I like the way this drug looks.
I forgot to mention that at least one study found vortioxetine to be effective for treating GAD.
- Scott
Posted by iforgotmypassword on August 27, 2012, at 3:26:07
In reply to Re: Vortioxetine: A new antidepressant?, posted by SLS on August 24, 2012, at 6:39:43
this makes drugs toxic to enough people, and we have a full smorgasboard of those drugs if anyone wants the mechanism added as an adjunct. aside from that i'm interested in the partial 1b agonism, as that is theorised to be in combo with light 1a agonism (NOT partial agonism) an extremely effective treatment for parkinson's dyskinesias, so proposedly maybe a bunch of things movement related. but again, i'm suspicious that this isn't just another drug that will pass because it resembles basically everything else, but is different enough to claim otherwise.
Posted by papillon2 on August 27, 2012, at 4:03:58
In reply to Re: Vortioxetine: A new antidepressant?, posted by SLS on August 24, 2012, at 6:39:43
I can see the ads in our future... Vortioxetine: for when your life is in a spin.
Posted by SLS on August 27, 2012, at 6:07:33
In reply to why always the transporter affinity, posted by iforgotmypassword on August 27, 2012, at 3:26:07
> this makes drugs toxic to enough people, and we have a full smorgasboard of those drugs if anyone wants the mechanism added as an adjunct. aside from that i'm interested in the partial 1b agonism, as that is theorised to be in combo with light 1a agonism (NOT partial agonism) an extremely effective treatment for parkinson's dyskinesias, so proposedly maybe a bunch of things movement related. but again, i'm suspicious that this isn't just another drug that will pass because it resembles basically everything else, but is different enough to claim otherwise.
Why are interested in 5-HT1b agonism?Thanks.
- Scott
This is the end of the thread.
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