![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by Avenarius on April 12, 2012, at 12:41:08
I've been taking 45mg mirtazapine for 3 months and it's been an effective antidepressant for me with just a few manageable side effects:
1. I feel dizzy and stoned for about 3 hrs after taking it.
2. It's been difficult to wake up in the morning.
3. I need adderall so I can function until the grogginess wears off in the afternoon.Suddenly though, after 3 months, things have changed. I still feel a bit spaced out after taking it, but I wake up feeling very alert - too alert, really - and rather than needing adderall now I now need 1mg klonopin to take the edge off.
This all makes sense considering that mirtazapine boosts norepinephrine, which accounts to the increased alertness. (I feel the same as I felt on high doses of effexor.) I'm just surprised that the morning grogginess has suddenly disappeared.
Have I become desensitized to the antihistamine effects of mirtazapine? That's my theory. Anyone have a similar experience or different theory?
Posted by Phillipa on April 12, 2012, at 14:19:20
In reply to Mirtazapine - no longer hazy after 3 months, posted by Avenarius on April 12, 2012, at 12:41:08
I just know 15mg didn't touch me at all no sleepiness took a month and stopped. Phillipa
Posted by SLS on April 12, 2012, at 15:09:27
In reply to Mirtazapine - no longer hazy after 3 months, posted by Avenarius on April 12, 2012, at 12:41:08
Have you changed the brand of generic mirtazapine recently or added any drug that might be interacting with it? Your theory is as good as any other. I am just curious to know if you are getting more mirtazapine absorbed into your system. Some people see a lifting of the brain-fog and sedation at higher dosages. Have you ever tried going to 60 mg?
I'm glad you found something that works. Perhaps it is best to not make any treatment adjustments at this juncture.
- Scott
Posted by phidippus on April 14, 2012, at 21:31:30
In reply to Mirtazapine - no longer hazy after 3 months, posted by Avenarius on April 12, 2012, at 12:41:08
What's your diagnosis?
Eric
Posted by Avenarius on April 15, 2012, at 14:54:22
In reply to Re: Mirtazapine - no longer hazy after 3 months » Avenarius, posted by phidippus on April 14, 2012, at 21:31:30
Diagnosis - MDD (possibly atypical) + Anxiety
I think I must have made a mistake in the dose of mirtazapine or synthroid (though I couldn't find any evidence to that effect). After 3 day of increased energy and alertness the grogginess/lethargy has returned.
Posted by phidippus on April 15, 2012, at 20:14:27
In reply to Re: Mirtazapine - no longer hazy after 3 months » phidippus, posted by Avenarius on April 15, 2012, at 14:54:22
Could the grogginess be depression?
Ericc
Posted by Avenarius on April 15, 2012, at 21:23:48
In reply to Re: Mirtazapine - no longer hazy after 3 months » Avenarius, posted by phidippus on April 15, 2012, at 20:14:27
Uh, no. The grogginess is grogginess.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.