![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 3 to 27 of 27. Go back in thread:
Posted by Solstice on February 22, 2012, at 18:54:56
In reply to Re: Daughter's Saphris Complaint, posted by Beckett on February 22, 2012, at 18:37:52
> Solstice, I imagine she has an idea of what a quieter mind is because she has been doing well for a considerable period of time prior to this. This side-effect will likely be one you'll both need to watch closely to see if it remits. I only have my experience to share. This blank feeling your daughter described might be like what I described to my doc as my output being turned off. I was unable to respond quickly though I could understand. How much of this delay was due to illness and how much was the Saphris, I haven't determined. I wish I had some real knowledge or understanding to share with you. Maybe it will be a question of dosage.... I am glad to hear your daughter had a good night's rest.
>I appreciate the info, Beckett. Sometimes it's easier for me to understand when an adult describes it. And you're right - I hadn't thought of it - but she has been rolling along for almost 3 yrs on Geodon with a much more cooperative mind than she's had the last several months.
She's only taking 10mg at night right now. How long did you take Saphris, and how many mg and when did you take it? Please tell me anything you came up with that was helpful - and anything you can think of that would be good for me to know about it. I know it works different for everybody, but if I get as much info as I can, then I'll know what's going on if any of it pops up for my daughter.
Solstice
Posted by Phillipa on February 22, 2012, at 20:02:25
In reply to Re: Daughter's Saphris Complaint » Beckett, posted by Solstice on February 22, 2012, at 18:54:56
Maybe the dose is too high? No experience sorry, no anti med. Phillipa
Posted by Beckett on February 22, 2012, at 22:26:55
In reply to Re: Daughter's Saphris Complaint » Beckett, posted by Solstice on February 22, 2012, at 18:54:56
>
> She's only taking 10mg at night right now. How long did you take Saphris, and how many mg and when did you take it?There isn't much out there about Saphris, is there? At least I found that to be so. Scott, I believe helped me parse some info. I looked in the archives of other med forums, too.
I took it for about two months, mostly 5 mg once a night. There was some cognitive dulling, but the trade-off was good. The gathering depression lifted and I experienced 'constructive' creativity. I picked up old projects and made them work again. It made up for any recall problems I might have experienced.
I took 10 mg for maybe ten days during a hypomanic episode. That slowed me down. When I returned to my original 5 mg dose, I was very depressed and slowed down. I felt stuck in molasses and blamed the Saphris. The problems with delay were not budging. I really do not understand it, Solstice, but that was my experience.
>>Please tell me anything you came up with that was helpful - and anything you can think of that would be good for me to know about it. I know it works different for everybody, but if I get as much info as I can, then I'll know what's going on if any of it pops up for my daughter.
A few other posters use Saphris. I hope they see your post and share their experience and any information.
Oh yes, btw, I do understand that agitated mind, even though I present as a placid patient and am rarely dramatic. When not treated, my mind is very reactive. Hyper-reactive. Saphris when it worked slowed me down well enough to be able to hold thoughts still. Risperidone at a low dose did the same thing. My doc wanted to put me on geodon, but circumstance conspired against that. He was going away and would need to supervise, I am on Emsam, an MAOI, and would likely need to withdraw. His next choice was Latuda since it is like geodon, but he needed to supervise that as well. So Saphris was chosen. Practical medicine is wonderful. Hope something here might help.
Posted by Solstice on February 22, 2012, at 22:40:19
In reply to Re: Daughter's Saphris Complaint » Solstice, posted by Phillipa on February 22, 2012, at 20:02:25
Gosh.. by 8pm, my daughter was so irritable. She announced that she was NOT going to take that nasty medicine. She went on her typical hypo-manic pressured talking jag.. would not stop complaining about the taste and she found close to one million different ways to describe how awful it tastes.. "like cat poo that's been eaten and thrown up." Then she complained about the 'stupid' scientists who couldn't figure out how to make something not taste so bad. This went on for 45 minutes! I told her that her only other anti-psychotic options are those that cause weight gain, so she'd have to choose between a 30 min nasty taste every evening, or gaining weight. She was so angry. She stormed off to take a shower, but when she came back down she was a different person. The pressured random fast-talking was still going on, but she was silly - happy - giggling - had the kitten in her lap while she sang 'Thriller' and had the kitten 'dancing' to it. Real excitable and non-stop talking. *whew* it's exhausting.
I researched some things.. reading patient reviews.. and a lot of them said that initially they felt the brain-fog, but that it went away after a week or so. A lot of them also said they split their dose in half for several days before going back up to their prescribed dose. A good number of them were only prescribed 5mg.. and my daughter's is 10mg. So in order to hopefully minimize the brain-fog issue for her tomorrow at school, I split her dose so she took 5mg instead of 10. Maybe Friday night we'll go back to 10 and see if by the time school starts again Monday, maybe she'll feel clear headed.
I invite any feedback from anyone who has any info about Saphris!
Solstice
Posted by Beckett on February 22, 2012, at 23:33:53
In reply to Re: Daughter's Saphris Complaint, posted by Solstice on February 22, 2012, at 22:40:19
I am one of the few people who actually likes the taste of that stuff. Sour cherry would be closer to the truth.
I'm glad you found some positive reviews out there to work with :-)
Posted by Solstice on February 23, 2012, at 9:36:07
In reply to Re: Daughter's Saphris Complaint » Solstice, posted by Beckett on February 22, 2012, at 23:33:53
> I am one of the few people who actually likes the taste of that stuff. Sour cherry would be closer to the truth.
You're kidding! You're the first one!
I had her take half of the 5 mg last night, and she actually didn't complain about it much. Some of the reviews I read said that after they had taken it a few times, it didn't bother them so much. Maybe it's an acquired taste, like a lot of alcoholic drinks :-)
One thing I'm wondering about, though, is I want to know what the important elements are of this sublingual administration. Some reviewers have said to make sure you make your mouth as dry as possible first - which makes sense because then you're not holding a pool of saliva that gets on your taste budes. But some have said they do things like put an altoid inthere with it.. or a listerine strip.. or various other things in an attempt to offset the bad taste.
But.. what's with the 'don't eat or drink for 10 minutes?'
- Does that mean a mint should NOT be in your mouth while it dissolves?And my daughter says it makes her salivate - so what does she do with that?
- Does she hold the saliva while it disolves, and then swallow it? or..
- Is she supposed to spit the saliva out?And as for placement..
- Does it matter whether it's under the front of the tongue, or can it be under the back part of the tongue?
- What is the purpose of putting it under the tonuge? Once it dissolves and there's saliva, it's all over the inside of the mouth, and when my daughter has swallowed, she says it makes her throat a little numb too. I wish I understood how to make sure the administration is supposed to work.
>
> I'm glad you found some positive reviews out there to work with :-)Yeah.. but a lot of them are a year or two old, so I can't ask any of them questions.. so I hope to hear from folks here!
Solstice
Posted by Lou Pilder on February 23, 2012, at 16:52:47
In reply to Re: Daughter's Saphris Complaint, posted by Solstice on February 22, 2012, at 22:40:19
> Gosh.. by 8pm, my daughter was so irritable. She announced that she was NOT going to take that nasty medicine. She went on her typical hypo-manic pressured talking jag.. would not stop complaining about the taste and she found close to one million different ways to describe how awful it tastes.. "like cat poo that's been eaten and thrown up." Then she complained about the 'stupid' scientists who couldn't figure out how to make something not taste so bad. This went on for 45 minutes! I told her that her only other anti-psychotic options are those that cause weight gain, so she'd have to choose between a 30 min nasty taste every evening, or gaining weight. She was so angry. She stormed off to take a shower, but when she came back down she was a different person. The pressured random fast-talking was still going on, but she was silly - happy - giggling - had the kitten in her lap while she sang 'Thriller' and had the kitten 'dancing' to it. Real excitable and non-stop talking. *whew* it's exhausting.
>
> I researched some things.. reading patient reviews.. and a lot of them said that initially they felt the brain-fog, but that it went away after a week or so. A lot of them also said they split their dose in half for several days before going back up to their prescribed dose. A good number of them were only prescribed 5mg.. and my daughter's is 10mg. So in order to hopefully minimize the brain-fog issue for her tomorrow at school, I split her dose so she took 5mg instead of 10. Maybe Friday night we'll go back to 10 and see if by the time school starts again Monday, maybe she'll feel clear headed.
>
> I invite any feedback from anyone who has any info about Saphris!
>
> Solstice
>
> Solstice,
You wrote,[...I invite any feedback from anyone...].
The subject here is the use of the drug {Saphris}.
The drug has a constituant in it that was used as a gas in riot control in the 50's.
Lou
Posted by Solstice on February 23, 2012, at 17:10:11
In reply to Lou's response-knervehyjent » Solstice, posted by Lou Pilder on February 23, 2012, at 16:52:47
> > Gosh.. by 8pm, my daughter was so irritable. She announced that she was NOT going to take that nasty medicine. She went on her typical hypo-manic pressured talking jag.. would not stop complaining about the taste and she found close to one million different ways to describe how awful it tastes.. "like cat poo that's been eaten and thrown up." Then she complained about the 'stupid' scientists who couldn't figure out how to make something not taste so bad. This went on for 45 minutes! I told her that her only other anti-psychotic options are those that cause weight gain, so she'd have to choose between a 30 min nasty taste every evening, or gaining weight. She was so angry. She stormed off to take a shower, but when she came back down she was a different person. The pressured random fast-talking was still going on, but she was silly - happy - giggling - had the kitten in her lap while she sang 'Thriller' and had the kitten 'dancing' to it. Real excitable and non-stop talking. *whew* it's exhausting.
> >
> > I researched some things.. reading patient reviews.. and a lot of them said that initially they felt the brain-fog, but that it went away after a week or so. A lot of them also said they split their dose in half for several days before going back up to their prescribed dose. A good number of them were only prescribed 5mg.. and my daughter's is 10mg. So in order to hopefully minimize the brain-fog issue for her tomorrow at school, I split her dose so she took 5mg instead of 10. Maybe Friday night we'll go back to 10 and see if by the time school starts again Monday, maybe she'll feel clear headed.
> >
> > I invite any feedback from anyone who has any info about Saphris!
> >
> > Solstice
> >
> > Solstice,
> You wrote,[...I invite any feedback from anyone...].
> The subject here is the use of the drug {Saphris}.
> The drug has a constituant in it that was used as a gas in riot control in the 50's.
> Lou
>
>okay... Lou... I think you understand from the context of my post that I am inviting information from those who have taken or are taking Saphris that would assist me in addressing how my daughter is experiencing Saphris. Any attempts on your part to use this thread as yet another soapbox to warn about the evils of this, or any other, medication/s is inappropriate and not welcome. However, feel free to transfer my post and anything you have to say about Saphris to your "Lou's Little Shoppe" thread.
What you are doing feels exploitive. Please stop.
Solstice
Posted by SLS on February 23, 2012, at 17:23:16
In reply to Lou's response-knervehyjent » Solstice, posted by Lou Pilder on February 23, 2012, at 16:52:47
> Solstice,
> You wrote,[...I invite any feedback from anyone...].
> The subject here is the use of the drug {Saphris}.
> The drug has a constituant in it that was used as a gas in riot control in the 50's.
> Lou
I am disappointed to see this post.
- Scott
Posted by Christ_empowered on February 23, 2012, at 18:07:34
In reply to Re: Daughter's Saphris Complaint, posted by Solstice on February 23, 2012, at 9:36:07
I hope things work out. I don't know anything about the newer neuroleptics. Have you considered trying an Orthomolecular approach? I know, sounds...crazy...but it worked for me. I'm down to just the Abilify, 30mgs/day, plus a ton of supplements. Contrary to popular belief, mega-vitamin therapy is designed to work with meds, not replace them, although I've found (as have many other people with severe mental problems) that the Orthomolecular approach makes medication(s) work better and keeps side effects to a minimum.
Obviously, I still have ups and downs, but they fall short of being acute mood and/or psychotic episodes, and a lot of them are due to psychosocial factors.
I'm clearly not anti-drugs. I just wanted to throw that the Orthomolecular option out there, since it seems like you're reaching the point at which sides from the drug(s) are getting to be a problem and med management is getting to be a bit tricky.
Posted by Lou Pilder on February 23, 2012, at 22:26:04
In reply to Re: Daughter's Saphris Complaint » Lou Pilder, posted by Solstice on February 23, 2012, at 17:10:11
> > > Gosh.. by 8pm, my daughter was so irritable. She announced that she was NOT going to take that nasty medicine. She went on her typical hypo-manic pressured talking jag.. would not stop complaining about the taste and she found close to one million different ways to describe how awful it tastes.. "like cat poo that's been eaten and thrown up." Then she complained about the 'stupid' scientists who couldn't figure out how to make something not taste so bad. This went on for 45 minutes! I told her that her only other anti-psychotic options are those that cause weight gain, so she'd have to choose between a 30 min nasty taste every evening, or gaining weight. She was so angry. She stormed off to take a shower, but when she came back down she was a different person. The pressured random fast-talking was still going on, but she was silly - happy - giggling - had the kitten in her lap while she sang 'Thriller' and had the kitten 'dancing' to it. Real excitable and non-stop talking. *whew* it's exhausting.
> > >
> > > I researched some things.. reading patient reviews.. and a lot of them said that initially they felt the brain-fog, but that it went away after a week or so. A lot of them also said they split their dose in half for several days before going back up to their prescribed dose. A good number of them were only prescribed 5mg.. and my daughter's is 10mg. So in order to hopefully minimize the brain-fog issue for her tomorrow at school, I split her dose so she took 5mg instead of 10. Maybe Friday night we'll go back to 10 and see if by the time school starts again Monday, maybe she'll feel clear headed.
> > >
> > > I invite any feedback from anyone who has any info about Saphris!
> > >
> > > Solstice
> > >
> > > Solstice,
> > You wrote,[...I invite any feedback from anyone...].
> > The subject here is the use of the drug {Saphris}.
> > The drug has a constituant in it that was used as a gas in riot control in the 50's.
> > Lou
> >
> >
>
> okay... Lou... I think you understand from the context of my post that I am inviting information from those who have taken or are taking Saphris that would assist me in addressing how my daughter is experiencing Saphris. Any attempts on your part to use this thread as yet another soapbox to warn about the evils of this, or any other, medication/s is inappropriate and not welcome. However, feel free to transfer my post and anything you have to say about Saphris to your "Lou's Little Shoppe" thread.
>
> What you are doing feels exploitive. Please stop.
>
> SolsticeSolstice,
You wrote that you invite anyone to give any feedback about any info concerning Saphris.
The grammatical structure of your statement uses the word {any} and {anyone}
I am included and any feedback is included, thearfore I responded to your invitation thinking that you meant what you wrote. Your exception is posted after the fact, so I could not know that. Although you have in the past wanted what you say, I took what you wrote as that you were now rescinding that and was opening responses to have no exclusions, hence the words {any} and {anyone}.
Lou
Posted by Solstice on February 23, 2012, at 22:47:29
In reply to Lou's reply-expozfaktoe » Solstice, posted by Lou Pilder on February 23, 2012, at 22:26:04
> Solstice,
> You wrote that you invite anyone to give any feedback about any info concerning Saphris.
> The grammatical structure of your statement uses the word {any} and {anyone}
> I am included and any feedback is included, thearfore I responded to your invitation thinking that you meant what you wrote. Your exception is posted after the fact, so I could not know that. Although you have in the past wanted what you say, I took what you wrote as that you were now rescinding that and was opening responses to have no exclusions, hence the words {any} and {anyone}.
> LouYou are too intelligent to have misunderstood what I was seeking. I think you might be making yourself look bad.
`
Solstice
Posted by Lou Pilder on February 23, 2012, at 22:55:27
In reply to Re: Lou » Lou Pilder, posted by Solstice on February 23, 2012, at 22:47:29
>
> > Solstice,
> > You wrote that you invite anyone to give any feedback about any info concerning Saphris.
> > The grammatical structure of your statement uses the word {any} and {anyone}
> > I am included and any feedback is included, thearfore I responded to your invitation thinking that you meant what you wrote. Your exception is posted after the fact, so I could not know that. Although you have in the past wanted what you say, I took what you wrote as that you were now rescinding that and was opening responses to have no exclusions, hence the words {any} and {anyone}.
> > Lou
>
>
>
> You are too intelligent to have misunderstood what I was seeking. I think you might be making yourself look bad.
> `
> SolsticeSolstice,
You wrote that I was too intellegent to have {misunderstood}.
I understood what the invitation stated as it could be seen. Only if it can be seen can I know it. I took you at your word, as what you wrote that I could see.
Lou
Posted by SLS on February 24, 2012, at 5:31:02
In reply to Lou's reply- » Solstice, posted by Lou Pilder on February 23, 2012, at 22:55:27
> Solstice,
> You wrote that I was too intellegent to have {misunderstood}.
> I understood what the invitation stated as it could be seen. Only if it can be seen can I know it. I took you at your word, as what you wrote that I could see.
> LouThe poster also requested in the very first post along this thread:
"oh.. please no anti-med posts."
Do you have any trouble interpreting the desires of the poster through these words?
I posted along your thread your concerns regarding Saphris in order to accede to the wishes of the poster whom you are petitioning here.
http://www.dr-bob.org/babble/20120221/msgs/1011308.html
You are wrong regarding Saphris.
Saphris has no toxic benzene properties and is not metabolized into benzene in the body. No toxic gases are evolved.
Your posts here are off-topic. Implicit in the questions of the above poster is the desire for clinical information about Saphris, not theories that are not founded in chemistry. This is also not a lesson in grammar.
For the sake of the poster here, would you please continue this conversation along another thread?
Thanks.
- Scott
Posted by ed_uk2010 on February 24, 2012, at 13:46:17
In reply to Re: Lou » Lou Pilder, posted by Solstice on February 23, 2012, at 22:47:29
>You are too intelligent to have misunderstood what I was seeking.
Not intelligent enough to understand the basics of organic chemistry.
Posted by shot_away on February 24, 2012, at 14:56:54
In reply to Re: Lou » Solstice, posted by ed_uk2010 on February 24, 2012, at 13:46:17
> >You are too intelligent to have misunderstood what I was seeking.
>
> Not intelligent enough to understand the basics of organic chemistry.hehe
Posted by Lou Pilder on February 24, 2012, at 16:04:57
In reply to Lou's reply- » Solstice, posted by Lou Pilder on February 23, 2012, at 22:55:27
Friends,
On of the important aspects of this discussion is about what happenes in the body to the chemical componants of the drug taken.
Let us look at fluoride, which is in many psychotropic drugs such as Prozac and Paxil and Luvox and Lexapro and Celexa. Also in Phen-fen and the date-rape drug which is fluorinated benzodiazepine, about 30 times more powerful.
What happens to the drug is that the liver acts on the drug too eliminate it and compounds are formed. Those compounds are called {matabolites}. Alt of different drugs have tthe same active matabolite as enzymes change the drug into the compound to elimiate it by breaking it down.
Now fluoride is highly toxic to the liver and interfers with the matabolism of thyroid hormones which can cause thyroid dysfunction. Now the fluuorine ion is an enzym inhibitor and can cause memory loss. Prozachas 3 fluorine atoms in each molocule that kill enzymes in the brain that are needed for normal mood stability and also can cause liver disease by fluorophenyl componds.
Now when organic fluorides are tranformed in the liver, the matabolite can have a greater toxicity than the original compound. Prozac can cause hepatitus and liver tumors.
So when you take other drugs, the matabolites have their effect on the body because the liver can break down by enzymes the original compound into a compound with greater toxicity, be it prozac or Saphris or other drugs.
Now it is my deep conviction that if anyone was told to take a mind-altering drug, and they knew what I could could post about here, that they could make a more informed decision as to take the drug or not and IMHHHHO save lives and prevent life-ruining conditions that can happen as a result of taking these drugs in question here. There is an ongoing compilation of suicides, deaths and life-ruining conditions that people taking psychotropic drugs get.
Now the tobacco companies hire doctors and researchers to make reports that ciggeretts do not cause cancer. So I do not give credence to reports done by the manufacturers of mind-altering drugs, nor do I even read their reports to the FDA, for the subjects are screened. I like the real-world reports cataloged and compiled by indepedent agencies that do not receive money from the drug companies.
Here is a link from a site that catalogs real-world outcomes.
Lou
http://www.ehealthme.com/ds/saphris/completed+suicide
Posted by Lou Pilder on February 24, 2012, at 16:18:42
In reply to Lou's response-itzihndair, posted by Lou Pilder on February 24, 2012, at 16:04:57
> Friends,
> On of the important aspects of this discussion is about what happenes in the body to the chemical componants of the drug taken.
> Let us look at fluoride, which is in many psychotropic drugs such as Prozac and Paxil and Luvox and Lexapro and Celexa. Also in Phen-fen and the date-rape drug which is fluorinated benzodiazepine, about 30 times more powerful.
> What happens to the drug is that the liver acts on the drug too eliminate it and compounds are formed. Those compounds are called {matabolites}. Alt of different drugs have tthe same active matabolite as enzymes change the drug into the compound to elimiate it by breaking it down.
> Now fluoride is highly toxic to the liver and interfers with the matabolism of thyroid hormones which can cause thyroid dysfunction. Now the fluuorine ion is an enzym inhibitor and can cause memory loss. Prozachas 3 fluorine atoms in each molocule that kill enzymes in the brain that are needed for normal mood stability and also can cause liver disease by fluorophenyl componds.
> Now when organic fluorides are tranformed in the liver, the matabolite can have a greater toxicity than the original compound. Prozac can cause hepatitus and liver tumors.
> So when you take other drugs, the matabolites have their effect on the body because the liver can break down by enzymes the original compound into a compound with greater toxicity, be it prozac or Saphris or other drugs.
> Now it is my deep conviction that if anyone was told to take a mind-altering drug, and they knew what I could could post about here, that they could make a more informed decision as to take the drug or not and IMHHHHO save lives and prevent life-ruining conditions that can happen as a result of taking these drugs in question here. There is an ongoing compilation of suicides, deaths and life-ruining conditions that people taking psychotropic drugs get.
> Now the tobacco companies hire doctors and researchers to make reports that ciggeretts do not cause cancer. So I do not give credence to reports done by the manufacturers of mind-altering drugs, nor do I even read their reports to the FDA, for the subjects are screened. I like the real-world reports cataloged and compiled by indepedent agencies that do not receive money from the drug companies.
> Here is a link from a site that catalogs real-world outcomes.
> Lou
> http://www.ehealthme.com/ds/saphris/completed+suicideMy apology.I inadvertanly posted this in the wrong thread . I would like someone that knows how to redirect this post to the thread of Lou's Little Shoppe.
Thanks in advance,
Lou
Posted by ed_uk2010 on February 24, 2012, at 16:27:19
In reply to Lou's response-itzihndair, posted by Lou Pilder on February 24, 2012, at 16:04:57
>Alt of different drugs have tthe same active matabolite
No, they do not all have the same active metabolites.
>http://www.ehealthme.com/ds/saphris/completed+suicide
This is one of the most pointless websites I have ever seen.
Posted by ed_uk2010 on February 24, 2012, at 16:47:37
In reply to Re: Daughter's Saphris Complaint, posted by Solstice on February 23, 2012, at 9:36:07
>But.. what's with the 'don't eat or drink for 10 minutes?'
Asenapine is very poorly absorbed when it is swallowed. It is mainly absorbed from the lining of the mouth. If she eats or drinks within 10 minutes, the drug is likely to be washed away from the lining of the mouth and swallowed.
>And my daughter says it makes her salivate - so what does she do with that?
> - Does she hold the saliva while it disolves, and then swallow it? or..
> - Is she supposed to spit the saliva out?If she spits the saliva out she would probably spit some of the dose out.
>What is the purpose of putting it under the tongue?To reduce the chance that the tablet will be swallowed. Also, the underside of the tongue is very vascular and this is good for absorption.
Posted by Lou Pilder on February 24, 2012, at 16:54:09
In reply to Re: Lou's response-itzihndair » Lou Pilder, posted by ed_uk2010 on February 24, 2012, at 16:27:19
> >Alt of different drugs have tthe same active matabolite
>
> No, they do not all have the same active metabolites.
>
> >http://www.ehealthme.com/ds/saphris/completed+suicide
>
> This is one of the most pointless websites I have ever seen.
>
> Friends,
There is a typo in the post by me.
See:
http://www.dr-bob.org/babble/20120221/msgs/1011417.html
Posted by Solstice on February 24, 2012, at 17:22:26
In reply to Re: Daughter's Saphris Complaint » Solstice, posted by ed_uk2010 on February 24, 2012, at 16:47:37
Thanks so much for the explanation, ed_uk..
> Asenapine is very poorly absorbed when it is swallowed. It is mainly absorbed from the lining of the mouth. If she eats or drinks within 10 minutes, the drug is likely to be washed away from the lining of the mouth and swallowed.It dissolves pretty quickly. How long should she hold the saliva in her mouth to ensure maximum absorption (before swallowing)?
Thank you so much for the additional explanation.. it really helped me get a better feel for what we're trying to do here.
Solstice
Posted by Phillipa on February 24, 2012, at 18:10:36
In reply to Re: Daughter's Saphris Complaint » ed_uk2010, posted by Solstice on February 24, 2012, at 17:22:26
Plus the med is absorbed more quickly sublingually. Like nitro glycernine for someone with chest pain. Phillipa
Posted by ed_uk2010 on February 25, 2012, at 3:23:05
In reply to Re: Daughter's Saphris Complaint » ed_uk2010, posted by Solstice on February 24, 2012, at 17:22:26
>How long should she hold the saliva in her mouth to ensure maximum absorption (before swallowing)?
I imagine that holding the saliva in the mouth for 10 mins would increase absorption but it would not be practical at all! The manufacturer does *not* suggest that you should try not to swallow saliva - patients in trials were not told to avoid swallowing their saliva. It's only important to avoid swallowing the whole tablet, which is one of the reasons for placing it under the tongue. The manufacturer says you can eat/drink after 10 minutes. Nothing should be spat out. When taken correctly, about a third of the dose is absorbed, the rest is swallowed and not absorbed.
Since your daughter seems to be finding asenapine quite strong, I wouldn't worry too much about trying to increase the absorption any further by holding saliva in the mouth for ages. It might be best for a bit less to be absorbed, it could make the medication more tolerable.
Posted by Beckett on February 25, 2012, at 9:11:37
In reply to Daughter's Saphris Complaint, posted by Solstice on February 22, 2012, at 17:56:25
My doctor said placing the wafer between the cheek and the gum was also effective. I found that to be true in my case and that it lessened salivation. The underside of my tongue would become tender from the Saphris, and I found having more rotation sites optimal. I agree with Ed about not sweating the swallowing issue too much. I would avoid excessive swallowing for ten minutes while the Saphris dissolved. Part of this was finding optimal positions to rest my head (I was reclining in bed) and places in my mouth that would cut down on the saliva pooling to the point of discomfort. I also believe as a layman that if some saliva is swallowed and the back of the throat is numbed, that numbing suggests that some medicine is being absorbed in the clean, relatively dry vascular membranes of the throat.
I hope your sweetie is doing well.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
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