Posted by ed_uk2010 on February 25, 2012, at 3:23:05
In reply to Re: Daughter's Saphris Complaint » ed_uk2010, posted by Solstice on February 24, 2012, at 17:22:26
>How long should she hold the saliva in her mouth to ensure maximum absorption (before swallowing)?
I imagine that holding the saliva in the mouth for 10 mins would increase absorption but it would not be practical at all! The manufacturer does *not* suggest that you should try not to swallow saliva - patients in trials were not told to avoid swallowing their saliva. It's only important to avoid swallowing the whole tablet, which is one of the reasons for placing it under the tongue. The manufacturer says you can eat/drink after 10 minutes. Nothing should be spat out. When taken correctly, about a third of the dose is absorbed, the rest is swallowed and not absorbed.
Since your daughter seems to be finding asenapine quite strong, I wouldn't worry too much about trying to increase the absorption any further by holding saliva in the mouth for ages. It might be best for a bit less to be absorbed, it could make the medication more tolerable.
poster:ed_uk2010
thread:1011236
URL: http://www.dr-bob.org/babble/20120221/msgs/1011490.html