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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 15 of 15. This is the beginning of the thread.
Posted by Bob on November 19, 2010, at 14:58:08
Is Valdoxan available in the U.S. market?
Are they making samples available to pdocs?Bob
Posted by Bob on November 19, 2010, at 15:02:03
In reply to Valdoxan availability, posted by Bob on November 19, 2010, at 14:58:08
Also, are there issues of compatibility with SSRIs, such as serotonin syndrome, or is it safe to coadminister with serotonergic meds?
Thanks,
Bob
Posted by ed_uk2010 on November 19, 2010, at 16:38:42
In reply to Valdoxan availability, posted by Bob on November 19, 2010, at 14:58:08
>Valdoxan available in the U.S. market?
No. It is not marketed in the US. It is available in Europe.
Posted by Bob on November 19, 2010, at 19:40:10
In reply to Re: Valdoxan availability, posted by ed_uk2010 on November 19, 2010, at 16:38:42
> >Valdoxan available in the U.S. market?
>
> No. It is not marketed in the US. It is available in Europe.
>That sucks.
Posted by sigismund on November 19, 2010, at 20:47:36
In reply to Re: Valdoxan availability, posted by Bob on November 19, 2010, at 15:02:03
>or is it safe to coadminister with serotonergic meds?
AFAIK, yes.
Posted by hyperfocus on November 23, 2010, at 10:27:41
In reply to Re: Valdoxan availability, posted by Bob on November 19, 2010, at 19:40:10
"In March 2006, Servier announced it had sold the rights to market agomelatine in the United States to Novartis.[7] It is currently undergoing phase III clinical trials in the US. Novartis lists the drug as scheduled for submission to the FDA no earlier than 2012.[8] It is currently sold in Australia under the Valdoxan trade name."
Posted by sigismund on November 23, 2010, at 11:31:44
In reply to Re: Valdoxan availability, posted by hyperfocus on November 23, 2010, at 10:27:41
A$60 for 28 tablets, one month's supply.
Posted by Bob on November 23, 2010, at 21:02:09
In reply to Re: Valdoxan availability, posted by hyperfocus on November 23, 2010, at 10:27:41
> "In March 2006, Servier announced it had sold the rights to market agomelatine in the United States to Novartis.[7] It is currently undergoing phase III clinical trials in the US. Novartis lists the drug as scheduled for submission to the FDA no earlier than 2012.[8] It is currently sold in Australia under the Valdoxan trade name."
>
> http://en.wikipedia.org/wiki/Valdoxan
Thanks for that info.Bob
Posted by Ron Hill on November 30, 2010, at 0:37:55
In reply to Valdoxan availability, posted by Bob on November 19, 2010, at 14:58:08
> Is Valdoxan available in the U.S. market?
-----------------------
Bob,Valdoxan (agomelatine) is available on-line. The FDA allows patients to purchase three months worth of meds at a time (i.e.; reorder every three months) from foreign sources.
Please read my earlier post:
http://www.dr-bob.org/babble/20101117/msgs/971872.html
-- Ron
Posted by Ron Hill on November 30, 2010, at 0:59:36
In reply to Re: Valdoxan availability, posted by Bob on November 19, 2010, at 15:02:03
> Also, are there issues of compatibility with SSRIs, such as serotonin syndrome, or is it safe to coadminister with serotonergic meds?
----------------------
Bob,Luvox is contraindicated, but the other SSRI's are likely okay. Co-administration with potent CYP1A2 inhibitors (e.g.; Luvox) are contraindicated.
See the "Interactions" section of the Valdoxan prescribing information document:
http://www.servier.co.uk/pdfs/Valdoxan_PI.pdf
-- Ron
Posted by Bob on November 30, 2010, at 13:24:56
In reply to Re: Valdoxan availability » Bob, posted by Ron Hill on November 30, 2010, at 0:37:55
> > Is Valdoxan available in the U.S. market?
> -----------------------
> Bob,
>
> Valdoxan (agomelatine) is available on-line. The FDA allows patients to purchase three months worth of meds at a time (i.e.; reorder every three months) from foreign sources.
>
> Please read my earlier post:
>
> http://www.dr-bob.org/babble/20101117/msgs/971872.html
>
> -- RonRon,
Thank you so much for the helpful information. If I were to inquire with my doctor about getting a 3 month supply of Valdoxan, what do you think I should tell him if he says he's not familiar with that?
Bob
Posted by Ron Hill on December 1, 2010, at 12:15:03
In reply to Re: Valdoxan availability » Ron Hill, posted by Bob on November 30, 2010, at 13:24:56
> If I were to inquire with my doctor about getting a 3 month supply of Valdoxan, what do you think I should tell him if he says he's not familiar with that?
----------------------------
Bob,Give your p-doc this link:
http://www.valdoxan.co.uk/landing.aspx?redirect=/Default.aspx
If your p-doc gives out his/her e-mail address (most don't), then send the link via e-mail. Or, you can block, copy, and paste the link into Word, save the Word file to a thumb drive, and hand the thumb drive to your p-doc.
Or, print out the complete document and hand it to your p-doc.
When I wanted to try Valdoxan, I discussed it with my p-doc. But, I'm the one who ordered it from the internet. I ordered it from a very professional website, and a prescription is not required. I reorder from the same website once every three months in full accordance with FDA rules. I'd like to tell you the URL of the on-line pharmacy website, but that is not allowed on p-babble.
Bob, what medications are you currently taking?
-- Ron
P.S. After you reply with the list of meds that you are currently taking, I can give you an e-mail address to contact me, if you want.
Posted by Bob on December 1, 2010, at 20:47:19
In reply to Re: Valdoxan availability » Bob, posted by Ron Hill on December 1, 2010, at 12:15:03
> > If I were to inquire with my doctor about getting a 3 month supply of Valdoxan, what do you think I should tell him if he says he's not familiar with that?
> ----------------------------
> Bob,
>
> Give your p-doc this link:
>
> http://www.valdoxan.co.uk/landing.aspx?redirect=/Default.aspx
>
> If your p-doc gives out his/her e-mail address (most don't), then send the link via e-mail. Or, you can block, copy, and paste the link into Word, save the Word file to a thumb drive, and hand the thumb drive to your p-doc.
>
> Or, print out the complete document and hand it to your p-doc.
>
> When I wanted to try Valdoxan, I discussed it with my p-doc. But, I'm the one who ordered it from the internet. I ordered it from a very professional website, and a prescription is not required. I reorder from the same website once every three months in full accordance with FDA rules. I'd like to tell you the URL of the on-line pharmacy website, but that is not allowed on p-babble.
>
> Bob, what medications are you currently taking?
>
> -- Ron
>
> P.S. After you reply with the list of meds that you are currently taking, I can give you an e-mail address to contact me, if you want.
>
>
Ron,I am currently taking 125mg sertraline, 70mg nortriptyline, and about .250mg Klonopin each night.
Bob
Posted by Ron Hill on December 2, 2010, at 2:11:35
In reply to Re: Valdoxan availability, posted by Bob on December 1, 2010, at 20:47:19
Bob,
> I am currently taking 125mg sertraline, 70mg nortriptyline, and about .250mg Klonopin each night.
Your p-doc might have a concern that Valdoxan (agomelatine) releases DA and NE in the frontal cortex due to the agonist action at 5-HT2c. Therefore, Valdoxan will add to the NE effects of nortriptyline.
However, Scott (SLS) took 25 mg/day of Valdoxan while taking Nardil and nortriptyline without any negative interactions. Further, I take Valdoxan with 90 mg/day of Nardil without any hint of a hypertensive crisis.
Valdoxan is metabolized mainly by cytochrome P450 1A2 (CYP1A2) (90%) and by CPY2C9/19 (10%). See the Valdoxan Prescribing Information document:
http://www.servier.co.uk/pdfs/Valdoxan_PI.pdf
Zoloft (sertraline) is metabolized by cytochrome P450 2D6. See page 23 of the Zoloft Prescribing Information document:
http://media.pfizer.com/files/products/uspi_zoloft.pdf#page=43
Pamelor (nortriptyline) is metabolized by cytochrome P450 2D6. See page 6 of the Pamelor Prescribing Information document:
http://www.psych.uic.edu/csp/Physicians/Patient%20package%20inserts/Pamelor.pdf
Klonopin is metabolized by cytochrome P450 3A. See page 8 of the Klonopin Prescribing Information document:
http://www.gene.com/gene/products/information/klonopin/pdf/pi.pdf
Therefore, there aren't any metabolism interactions between Valdoxan and the other meds that you are currently taking.
As an aside, please note that there is a metabolism interaction between Zoloft and nortriptyline. Therefore, there is an increase in the plasma concentrations of both Zoloft and nortriptyline in your body, above which would be expected for the dosages of the two meds.
Bob, if you don't mind my asking, what is your dx; OCD, PTSD, anxiety disorder, or ??
What do you hope to accomplish by adding Valdoxan; better sleep?
-- Ron
Posted by Bob on December 4, 2010, at 1:09:02
In reply to Re: Valdoxan availability » Bob, posted by Ron Hill on December 2, 2010, at 2:11:35
> Bob,
>
> > I am currently taking 125mg sertraline, 70mg nortriptyline, and about .250mg Klonopin each night.
>
> Your p-doc might have a concern that Valdoxan (agomelatine) releases DA and NE in the frontal cortex due to the agonist action at 5-HT2c. Therefore, Valdoxan will add to the NE effects of nortriptyline.
>
> However, Scott (SLS) took 25 mg/day of Valdoxan while taking Nardil and nortriptyline without any negative interactions. Further, I take Valdoxan with 90 mg/day of Nardil without any hint of a hypertensive crisis.
>
> Valdoxan is metabolized mainly by cytochrome P450 1A2 (CYP1A2) (90%) and by CPY2C9/19 (10%). See the Valdoxan Prescribing Information document:
>
> http://www.servier.co.uk/pdfs/Valdoxan_PI.pdf
>
> Zoloft (sertraline) is metabolized by cytochrome P450 2D6. See page 23 of the Zoloft Prescribing Information document:
>
> http://media.pfizer.com/files/products/uspi_zoloft.pdf#page=43
>
> Pamelor (nortriptyline) is metabolized by cytochrome P450 2D6. See page 6 of the Pamelor Prescribing Information document:
>
> http://www.psych.uic.edu/csp/Physicians/Patient%20package%20inserts/Pamelor.pdf
>
> Klonopin is metabolized by cytochrome P450 3A. See page 8 of the Klonopin Prescribing Information document:
>
> http://www.gene.com/gene/products/information/klonopin/pdf/pi.pdf
>
> Therefore, there aren't any metabolism interactions between Valdoxan and the other meds that you are currently taking.
>
> As an aside, please note that there is a metabolism interaction between Zoloft and nortriptyline. Therefore, there is an increase in the plasma concentrations of both Zoloft and nortriptyline in your body, above which would be expected for the dosages of the two meds.
>
> Bob, if you don't mind my asking, what is your dx; OCD, PTSD, anxiety disorder, or ??
>
> What do you hope to accomplish by adding Valdoxan; better sleep?
>
> -- Ron
>
>
RonMy diagnosis is essentially MDD, I have plenty of anxiety problems, irritability, and rumination obsession problems as well. This can all be blunted with SSRIs, but then the will to do anything or get joy out of anything is all but gone.
My hope with the Valdoxan would be to help my severely shifted circadian cycle. The longer I'm exposed to SSRIs the harder it is to get up in the morning and the harder it is to sleep at night. Eventually I find myself getting up in the early afternoon and staying up until 2 or 3 in the morning. I have been able to do little to nothing to change this over the 20 years I've been dealing with psych drugs. I also have problems with fatigue and drowsiness during the day as well.
Bob
This is the end of the thread.
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