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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by bearfan on October 3, 2010, at 19:12:16
My Doctor is okay with the idea of me going on Parnate, but I read quite a bit of disadvantages with the use (including fating, low blood pressure that causes ED, extreme fatigue etc.) plus all the drug and food restrictions. I'd say the SSRIs give about 65% remission but usually leave me sexless. Its a harder decision due to the fact I have to washout of the SSRI before I can take it, wait to it to work (which it might not).
Posted by emmanuel98 on October 3, 2010, at 19:56:45
In reply to Is Parnate worth trying if SSRIs work somewhat?, posted by bearfan on October 3, 2010, at 19:12:16
All I can tell you is that I had 100% remission on parnate. Drug and food interactions are barely worth thinking about, since it's easy to give up cheese and aged meats (how often do you eat salami anyway?)
The fainting and low blood pressure just happens if you get up too quickly from a lying position, so sit on the bed for 30 seconds before you get up. I found that this went away after a while anyway.
As far as fatigue goes, I know people on this site talk about being tired on parnate, but generally parnate is somewhat stimulating and imo the worst side effect is insomnia, which can be managed with benzos at night.
Posted by angels78 on October 3, 2010, at 21:25:31
In reply to Re: Is Parnate worth trying if SSRIs work somewhat?, posted by emmanuel98 on October 3, 2010, at 19:56:45
You had?
Posted by bearfan on October 3, 2010, at 21:44:49
In reply to Is Parnate worth trying if SSRIs work somewhat?, posted by bearfan on October 3, 2010, at 19:12:16
I forgot to mention I have tried Emsam and Moclobermide (Manerix) before with some success but increased agitation. I felt uncomfortable around people on Emsam (at least this was the first week). What scares me about Parnate is the drug and food reactions. Before I started Moclobermide, I was on Impramine PM the night before. I read somewhere that its okay to take a tricyclic with a MAOI (or RIMA in this case). I only took 75 Moclobermide that night and I had experienced most likely serotonin syndrome. My heart was beating very fast for no reason and I thought I was having a heart attack or something. I called ER and after taking a few xanax I calmed down. I am sure Parnate would not be nearly as forgiving. Although after SSRI/SNRIs I feel like I hit a brick wall in my depression. I would love to have a normal libido again and be able to stay on something consistantly.
Posted by brooklyn234 on October 4, 2010, at 1:50:44
In reply to Is Parnate worth trying if SSRIs work somewhat?, posted by bearfan on October 3, 2010, at 19:12:16
Just my opinion of course,but the wait period for washout is overrated i think,this is just my opinion,wish u luck
Posted by Metamorphosis on October 4, 2010, at 16:34:40
In reply to Re: Is Parnate worth trying if SSRIs work somewhat?, posted by brooklyn234 on October 4, 2010, at 1:50:44
I'm seriously considering Parnate as well. I'm a fairly active person and my main sport is cycling. Since that is an endurance sport with your body often going aerobic and anaerobic with HR going from @ 70-80 bp up to 170 bp max anaerobically. Is it safe to take a med. where hr and bp is so important to monitor? I hope not. That would bum me.
Posted by emmanuel98 on October 4, 2010, at 20:53:14
In reply to Re: Is Parnate worth trying if SSRIs work somewhat?, posted by Metamorphosis on October 4, 2010, at 16:34:40
You don't have to monitor BP and heart rate. The only problem parnate causes with BP is postural hypotension. This means BP can drop suddenly when you've been lying or sitting for a long time, then get up quickly. If you just take the time to get up slowly, there's no problem at all. And it only lasts a minute or two and tends to go away over time (at least it did for me). It's not like parnate messes with your heart rate or BP otherwise. I exercise regularly and have no problems whatsoever. I've been depression free for over a year on parnate.
Also, mixing meds is not recommended. Neither TCAs or SSRI's or even most AAPs can mix with parnate. But if parnate works, so what? I would try it. I have had no sexual side effects at all (but then I didn't have them on SSRIs either). Also, no weight gain unlike other psych drugs.
As for the washout period -- if your current AD isn't working, what's the problem with stopping it and waiting a couple of weeks to start a drug that has a better chance of working?
Posted by Maxime on October 9, 2010, at 16:14:03
In reply to Re: Is Parnate worth trying if SSRIs work somewhat?, posted by brooklyn234 on October 4, 2010, at 1:50:44
> Just my opinion of course,but the wait period for washout is overrated i think,this is just my opinion,wish u luck
I didn't do the washout period properly once and I had the worst reaction to Parnate.
Posted by bearfan on October 10, 2010, at 15:19:56
In reply to Re: Is Parnate worth trying if SSRIs work somewhat? » brooklyn234, posted by Maxime on October 9, 2010, at 16:14:03
What happened in the adverse reaction
Posted by Enigma on October 10, 2010, at 16:21:11
In reply to Is Parnate worth trying if SSRIs work somewhat?, posted by bearfan on October 3, 2010, at 19:12:16
> My Doctor is okay with the idea of me going on Parnate, but I read quite a bit of disadvantages with the use (including fating, low blood pressure that causes ED, extreme fatigue etc.) plus all the drug and food restrictions. I'd say the SSRIs give about 65% remission but usually leave me sexless. Its a harder decision due to the fact I have to washout of the SSRI before I can take it, wait to it to work (which it might not).
I might be a bad example, but MAOI's have severe and hefty side-effects, not just the food restrictions either. I would on recommend them as a last resort only.
Have you tried an ssri with some other med? (not sure what... but a med combo?)
I couldn't take Parnate due to the side effects, but took Nardil and now I can't get rid of the overheating/sweating side effect which in effect "somewhat" ruined my life. I can no longer stand any humidity, cannot move to a warmer climate, like I had planned.. can't really go to a beach, unless I'm in the water, constantly, etc, etc, etc. That's only ONE side effect. Been off Nardil for 2 months? I forget, the side effect still has not gone away. 2 people have told me that they think (for them) the side effect is not going away. I would avoid it just for that reason alone. There can be sexual side effects, if you are a man (inorgasmia), insomnia, and high blood pressure, and a plethora of other things... go to drugs.com and look it up. Nardil for example, has 2 pages of side effects. If you overheat on Nardil, you can actually get a heat stroke and die. Nice.
This is the end of the thread.
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