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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by linkadge on September 22, 2010, at 16:33:56
When I think of the ideal med it would be "soothing". I don't know of meds that fit that characteristic.
SSRIs aren't "soothing" for me. Some TCA's would fit the category of "soothing", but they are also sedating, and the properties seem to change over time.
I might consider certain mood stabilizers soothing, i.e. zyprexa or lithium, but these too seem to induce dysphoria.
Opiates or certain benzodiazapines seem to be the only meds that fit the category of purely soothing. You know, something that can calm you down, without inducing akathesia, or restlessness, or insomnia, paradoxical activation, or mood depressant effects.
The antidepressants are marketed as anxiolytics, but they are not anxiolytic in the way that benzodiazapines are. Its a totally different effect and ADs seem to be more unpredictable.
I.e. amitriptyline metabolizes to nortriptyline which can be stimulating. After the antihistamine effect wears off, the drug can be quite activating.Some of the mood stabilizers (ie. gabapentin) are used for a benzodiazapine like effect, less the tollerance.
We need better anxioltyics. I.e. drugs that *target* anxiety and insomnia without all the collateral effects of antidepressants or antipsychotics, or the mood depressant effects of antipsychotics or mood stabilizers.
You know, like a pharmacudical kava-kava. Now that was soothing. Who could ask for more than the pharmacudical equivilant of kava kava?
Linkadge
Posted by linkadge on September 22, 2010, at 16:36:46
In reply to 'soothing' is a key desirable quality (for me), posted by linkadge on September 22, 2010, at 16:33:56
or something like oxytocin (not oxycontin). I hear that has anxiolytic qualities and it probably doesn't give you akathesia, or start up anxiety, or dystonia, or agitation, or insomnia etc.
Linkadge
Posted by bulldog2 on September 22, 2010, at 16:54:23
In reply to Re: 'soothing' is a key desirable quality (for me), posted by linkadge on September 22, 2010, at 16:36:46
> or something like oxytocin (not oxycontin). I hear that has anxiolytic qualities and it probably doesn't give you akathesia, or start up anxiety, or dystonia, or agitation, or insomnia etc.
>
> LinkadgeI like low dose wellbutrin plus 300 mg lithium plus 2400 mg neurontin
Posted by bulldog2 on September 22, 2010, at 16:55:28
In reply to Re: 'soothing' is a key desirable quality (for me), posted by bulldog2 on September 22, 2010, at 16:54:23
> > or something like oxytocin (not oxycontin). I hear that has anxiolytic qualities and it probably doesn't give you akathesia, or start up anxiety, or dystonia, or agitation, or insomnia etc.
> >
> > Linkadge
>
> I like low dose wellbutrin plus 300 mg lithium plus 2400 mg neurontinAlso percocet in the morning for pain
Posted by Phillipa on September 22, 2010, at 17:32:04
In reply to Re: 'soothing' is a key desirable quality (for me), posted by bulldog2 on September 22, 2010, at 16:55:28
Not that would be soothing but in the past benozs just made me feel normal and happy and good. Phillipa
Posted by morgan miller on September 22, 2010, at 22:14:18
In reply to 'soothing' is a key desirable quality (for me), posted by linkadge on September 22, 2010, at 16:33:56
Hey Link, have you ever consider Afobazol? It may not have the soothing effect your looking for, but it has been shown to be effective for treating anxiety. It also is a sigma 1 receptor agonist, which may increase neuroplasticity.
Have you ever tried Holy Basil or Ashwagandha? They probably won't hold a candle to pharmaceutical Kava though.
Morgan
Posted by Maxime on September 25, 2010, at 6:06:55
In reply to 'soothing' is a key desirable quality (for me), posted by linkadge on September 22, 2010, at 16:33:56
Maybe what you are looking for cannot be found in a med. Are you familiar with self-soothing techniques? We learnt them in DBT. I can give you some ideas if you want.
Posted by linkadge on September 25, 2010, at 7:22:47
In reply to Re: 'soothing' is a key desirable quality (for me) » linkadge, posted by Maxime on September 25, 2010, at 6:06:55
I think it can be found in a med, I just don't think it has been developed yet. I don't think akathesia is a necessary component for the efficacy of an antidepressant.
Linkadge
This is the end of the thread.
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