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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by Jeroen on March 10, 2010, at 3:49:41
Sertindole and Abilify and Seroxat SAFE?????????
im worried bout the Seroxat here, doesnt it work on heart muscle too?
Cant afford too much QTc prolognation or i'm done
Posted by Phillipa on March 10, 2010, at 11:11:45
In reply to Sertindole and Abilify and Seroxat SAFE?????????, posted by Jeroen on March 10, 2010, at 3:49:41
Jeroen don't know did you google it? Love Phillipa
Posted by Jeroen on March 10, 2010, at 11:38:55
In reply to Re: Sertindole and Abilify and Seroxat SAFE????????? » Jeroen, posted by Phillipa on March 10, 2010, at 11:11:45
serdolect site sais precautions with seroxat and other SSRI anti depressants
Posted by ed_uk2010 on March 10, 2010, at 17:19:40
In reply to Sertindole and Abilify and Seroxat SAFE?????????, posted by Jeroen on March 10, 2010, at 3:49:41
Hi Jeroen,
Do you really need to be on two different antipsychotics at once?
Posted by Jeroen on March 11, 2010, at 1:09:42
In reply to Re: Sertindole and Abilify and Seroxat SAFE?????????, posted by ed_uk2010 on March 10, 2010, at 17:19:40
for the moment yes, but when sertindole is okay i will only take that one
Posted by Brainbeard on March 11, 2010, at 14:09:59
In reply to Sertindole and Abilify and Seroxat SAFE?????????, posted by Jeroen on March 10, 2010, at 3:49:41
Sertindole's QT-prolongation is dose related, so you could try and find the lowest effective dose. It has a long half-life, so it may take some time to figure that out.
SSRI's can also dose-dependently prolong QT-interval, although it's more rare.
I don't know about the Abilify - doesn't it leave the QT-interval alone? Otherwise this doesn't seem to be a risky combination to me. Throwing in a TCA or another med that significantly prolongs QT-interval, that would be risky. I wouldn't take more than 20mg of Seroxat just to be sure. Certainly not more than 40.
Practically no medication is totally safe. You could have an EKG to rule out trouble - couldn't you?
Posted by Jeroen on March 11, 2010, at 14:33:12
In reply to Re: Sertindole and Abilify and Seroxat SAFE?????????, posted by Brainbeard on March 11, 2010, at 14:09:59
Hi, Brainbeard, thanks for your message
the EKG was normal
Posted by Brainbeard on March 11, 2010, at 15:06:04
In reply to Hi, Brainbeard, posted by Jeroen on March 11, 2010, at 14:33:12
> Hi, Brainbeard, thanks for your message
> the EKG was normal
>
>
Most welcome. Good EKG, that's great. Wouldn't worry about it then.
Posted by ed_uk2010 on March 11, 2010, at 15:24:47
In reply to Sertindole and Abilify and Seroxat SAFE?????????, posted by Jeroen on March 10, 2010, at 3:49:41
On the bright side, sertindole tends to be relatively well tolerated apart from the risk of QT prolongation.
However... sertindole does interact with Seroxat. Seroxat increases the blood levels of sertindole and may increase the risk of toxicity.
Posted by Brainbeard on March 12, 2010, at 7:10:47
In reply to Re: Sertindole and Abilify and Seroxat SAFE?????????, posted by ed_uk2010 on March 11, 2010, at 15:24:47
> On the bright side, sertindole tends to be relatively well tolerated apart from the risk of QT prolongation.
>
> However... sertindole does interact with Seroxat. Seroxat increases the blood levels of sertindole and may increase the risk of toxicity.Whoa, that's vital information. Can't believed I missed that. I have this list of metabolic interactions, but sertindole's not on it. I tried to get it prescribed once, but my f-doc wasn't in for it.
Posted by ed_uk2010 on March 12, 2010, at 13:42:51
In reply to Re: Sertindole and Abilify and Seroxat SAFE?????????, posted by Brainbeard on March 12, 2010, at 7:10:47
Hi there,
Sertindole is completely missing from most lists of drug interactions because it is a rarely used drug.
Paroxetine (Seroxat) has many metabolic interactions due to inhibition of certain liver enzymes.
This is the end of the thread.
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