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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by linkadge on December 23, 2009, at 18:39:50
http://www.sciencedaily.com/releases/2009/12/091208132724.htm
Posted by SLS on December 23, 2009, at 18:59:43
In reply to New study MAO-A and depression, posted by linkadge on December 23, 2009, at 18:39:50
> http://www.sciencedaily.com/releases/2009/12/091208132724.htm
I know that I have mentioned this in the past, but I consider the most potent antidepressant in the world to be clorgyline, an irreversible inhibitor of MAO-A. It certainly felt that way to me. I would go back on it in a second if it were available to me again.
- Scott
Posted by Sigismund on December 23, 2009, at 19:17:48
In reply to Re: New study MAO-A and depression, posted by SLS on December 23, 2009, at 18:59:43
Hey Scott, can you describe in more detail the effect of clorgyline?
Or can you compare it to anything?
Do you know why it is not commercially available?
Posted by SLS on December 24, 2009, at 5:30:54
In reply to Re: New study MAO-A and depression » SLS, posted by Sigismund on December 23, 2009, at 19:17:48
Hi.
> Hey Scott, can you describe in more detail the effect of clorgyline?
It produced a broad and robust antidepressant response. It really cleared my head and gave me mental and physical energy. It brightened my mood and allowed me to experience reward and pleasure. I could think faster and remember better. I was more confident in myself and had much less social anxiety.
> Or can you compare it to anything?
It was as if one were to combine Nardil with either Parnate or amphetamine.
> Do you know why it is not commercially available?
The patent on clorgyline ran out 30 years ago. MAOIs had become unpopular and used less and less as the Prozac revolution emerged. I don't think any drug company was interested in developing it at that point. However, it remained available to the NIMH, NIH for clinical use until the mid 1990s. The NIMH liked to use it on people who did not respond to any other drug treatment. Unfortunately, two people people died of cardiovascular events while it was being used there. It may or may not have been an effect of the clorgyline, but it prompted the chemical supply company to discontinue its production for human use. It is still available as a biological probe and reagent for use in the lab.
- Scott
Posted by julie1977 on December 24, 2009, at 16:24:34
In reply to Re: New study MAO-A and depression » Sigismund, posted by SLS on December 24, 2009, at 5:30:54
I can testify to MAO inhibitors being the only ADs which work for me. I tried most classes of ADs from age 21-30, then I tried Nardil and it was totally different, it has obliterated my depression and lessened my social anxiety as a result. Thank god for Nardil
Posted by Netch on December 25, 2009, at 8:40:46
In reply to New study MAO-A and depression, posted by linkadge on December 23, 2009, at 18:39:50
I suspect reducing extracellular monoamine catabolites would alleviate symptoms.
Perhaps combining SSRE and MAOI might be optimal.
Posted by Sigismund on December 25, 2009, at 16:00:18
In reply to Re: New study MAO-A and depression, posted by Netch on December 25, 2009, at 8:40:46
SSRE is tianeptine?
I took 10mg Parnate while on tianeptine and didn't feel too good as a result.
>I suspect reducing extracellular monoamine catabolites would alleviate symptoms.
>Perhaps combining SSRE and MAOI might be optimal.
Posted by jedi on December 30, 2009, at 3:04:58
In reply to New study MAO-A and depression, posted by linkadge on December 23, 2009, at 18:39:50
> http://www.sciencedaily.com/releases/2009/12/091208132724.htm
Linkadge, Thanks for the link to the study. As a long time user of Nardil, I think I can see this as being true. I've tried to quit Nardil at least 6 times to try other meds and because of the side effects. Always, within a few months, my major depression returned. I have been on 45+ different combinations of medications and the only one that has worked for my atypical depression and social anxiety is phenelzine combined with clonazepam.
This study sure explains why. It would be so nice to have a clean drug that worked as well for me as a 50 year old "dirty" medication. It has not happened yet. At this point I am a lifer on phenelzine. And it has saved my life on multiple occasions.
Be well,
Jedi
This is the end of the thread.
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