Posted by SLS on December 24, 2009, at 5:30:54
In reply to Re: New study MAO-A and depression » SLS, posted by Sigismund on December 23, 2009, at 19:17:48
Hi.
> Hey Scott, can you describe in more detail the effect of clorgyline?
It produced a broad and robust antidepressant response. It really cleared my head and gave me mental and physical energy. It brightened my mood and allowed me to experience reward and pleasure. I could think faster and remember better. I was more confident in myself and had much less social anxiety.
> Or can you compare it to anything?
It was as if one were to combine Nardil with either Parnate or amphetamine.
> Do you know why it is not commercially available?
The patent on clorgyline ran out 30 years ago. MAOIs had become unpopular and used less and less as the Prozac revolution emerged. I don't think any drug company was interested in developing it at that point. However, it remained available to the NIMH, NIH for clinical use until the mid 1990s. The NIMH liked to use it on people who did not respond to any other drug treatment. Unfortunately, two people people died of cardiovascular events while it was being used there. It may or may not have been an effect of the clorgyline, but it prompted the chemical supply company to discontinue its production for human use. It is still available as a biological probe and reagent for use in the lab.
- Scott
poster:SLS
thread:930587
URL: http://www.dr-bob.org/babble/20091217/msgs/930663.html