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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 17 of 17. This is the beginning of the thread.
Posted by TriedEveryDrug on November 7, 2009, at 0:08:49
According to Shire it is available now.
I'm seeing my doc monday... I will most likely be getting a prescription for it (we've talked about it for months)
Just curious if anyone had tried it yet. :)Best regards.
Posted by Brain Damage on November 8, 2009, at 7:04:28
In reply to Anyone try Intuniv yet?, posted by TriedEveryDrug on November 7, 2009, at 0:08:49
What is IntIntuniv?
Posted by JustWantToBeNormal on November 8, 2009, at 10:12:18
In reply to Re: Anyone try Intuniv yet?, posted by Brain Damage on November 8, 2009, at 7:04:28
α2A norepinephrine agonist that supposedly "improves attention abilities via modulating post-synaptic α-2a receptors in the prefrontal cortex"
It is an XR version of the drug guanfacine.
http://en.wikipedia.org/wiki/Guanfacine
Posted by Maxime on November 8, 2009, at 10:38:54
In reply to Anyone try Intuniv yet?, posted by TriedEveryDrug on November 7, 2009, at 0:08:49
It's for ADHD isn't it?
Posted by floatingbridge on November 10, 2009, at 20:41:44
In reply to Anyone try Intuniv yet?, posted by TriedEveryDrug on November 7, 2009, at 0:08:49
No, but I'm curious. Read the Wiki link (thank you). Please let us know how it goes. May I ask what you are being treated for? ADHD?
good luck,
fb
Posted by TriedEveryDrug on November 10, 2009, at 21:52:28
In reply to Re: Anyone try Intuniv yet? » TriedEveryDrug, posted by floatingbridge on November 10, 2009, at 20:41:44
Yeah, this is for ADD, inattentive-type.
First half of the morning it made me more cheerful. The rest of the day it made me miserably depressed!!
(I see depression is a side of guanfacine - great)
I think I am a little more focused and social, though.
Too early to tell. This side-effect may be a deal breaker though.
Posted by floatingbridge on November 11, 2009, at 10:48:40
In reply to Took first dose today..., posted by TriedEveryDrug on November 10, 2009, at 21:52:28
> Yeah, this is for ADD, inattentive-type.
>
> First half of the morning it made me more cheerful. The rest of the day it made me miserably depressed!!
>
> (I see depression is a side of guanfacine - great)
>
> I think I am a little more focused and social, though.
>
> Too early to tell. This side-effect may be a deal breaker though.Yes, that is quite a side effect. I wonder if you can take in two doses?
let us know how you're doing,
fb
Posted by jparsell82 on November 15, 2009, at 17:35:24
In reply to Re: Took first dose today... » TriedEveryDrug, posted by floatingbridge on November 11, 2009, at 10:48:40
Thanks for sharing your experience... keep us updated. I'm headed to the doctor on Friday. I'd like to try a combo of Adderall or Vyvanse with a low dose of Intuniv and a low dose of Zoloft(25mg) to offset any depression. I'm ADD combined type.
Posted by TriedEveryDrug on November 15, 2009, at 18:09:19
In reply to Re: Took first dose today..., posted by jparsell82 on November 15, 2009, at 17:35:24
I have been ramping up from 1mg to 3mg. The max peds dose is 4mg, I calculate that in mg/kg, that would be closer to 11mg for adults, according to their mg/kg specifications on the prescribing sheet.
anyhoo... I think this stuff is making me (more) depressed. I feel a bit confused sometimes, and anxious over things I don't get anxious about. Also quick to anger on this stuff (NRIs have this affect on me as well). I get very drowsy sometimes, too.Not seeing a whole lot of attentional benefit. Maybe a little.
I don't know how long you're supposed to take this to see beneficial results.
Posted by Maxime on November 15, 2009, at 21:00:22
In reply to day 6..., posted by TriedEveryDrug on November 15, 2009, at 18:09:19
I wonder if you have to wait 4-6 weeks like with an antidepressant? I'm sorry that it's not helping you more.
Posted by floatingbridge on November 15, 2009, at 21:00:26
In reply to day 6..., posted by TriedEveryDrug on November 15, 2009, at 18:09:19
Hey there, thanks for the update--I had hoped for better news. Sorry. If I have time tonight, I'll google your med. I started an add-on of Strattera, which my pdoc told me to take at night because of drowsiness...(?). The jury is still out on this one.
I would think by day 6 something more positive rater than negative would be showing up. Any calls out to your doc?
fb
Posted by floatingbridge on November 15, 2009, at 21:10:55
In reply to day 6..., posted by TriedEveryDrug on November 15, 2009, at 18:09:19
> I have been ramping up from 1mg to 3mg. The max peds dose is 4mg, I calculate that in mg/kg, that would be closer to 11mg for adults, according to their mg/kg specifications on the prescribing sheet.
>
>
> anyhoo... I think this stuff is making me (more) depressed. I feel a bit confused sometimes, and anxious over things I don't get anxious about. Also quick to anger on this stuff (NRIs have this affect on me as well). I get very drowsy sometimes, too.
>
> Not seeing a whole lot of attentional benefit. Maybe a little.
>
> I don't know how long you're supposed to take this to see beneficial results.Well a very quick google did not reveal any information about intuit on adults--only children. Kid's brains are sooo different.
just an observation,
fb
Posted by TriedEveryDrug on November 15, 2009, at 21:15:31
In reply to Re: day 6... » TriedEveryDrug, posted by floatingbridge on November 15, 2009, at 21:00:26
> Hey there, thanks for the update--I had hoped for better news. Sorry. If I have time tonight, I'll google your med. I started an add-on of Strattera, which my pdoc told me to take at night because of drowsiness...(?). The jury is still out on this one.
>
> I would think by day 6 something more positive rater than negative would be showing up. Any calls out to your doc?
>
> fb
So there was nothing in the prescribing info pdf about when the stuff should work. but I found this on intunive.com:"In 2 clinical studies with INTUNIV lasting 8 and 9 weeks, ADHD symptoms started to improve within
2 weeks. For most patients, symptom improvement continued over the course of the studies."
So I guess I should not write it off yet...BTW, when I took strattera, my doc suggested taking it at night for the first 2 or 3 days then switching to morning, because once it is in your system, it can keep you up at night...
Good luck!
Posted by floatingbridge on November 15, 2009, at 21:16:08
In reply to day 6..., posted by TriedEveryDrug on November 15, 2009, at 18:09:19
O.K. so I'm officially hogging the thread. Strattera takes at least two weeks to show it's effects, sometimes longer--so I imagine your med may have a similar time table.
Best
fb
> I have been ramping up from 1mg to 3mg. The max peds dose is 4mg, I calculate that in mg/kg, that would be closer to 11mg for adults, according to their mg/kg specifications on the prescribing sheet.
>
>
> anyhoo... I think this stuff is making me (more) depressed. I feel a bit confused sometimes, and anxious over things I don't get anxious about. Also quick to anger on this stuff (NRIs have this affect on me as well). I get very drowsy sometimes, too.
>
> Not seeing a whole lot of attentional benefit. Maybe a little.
>
> I don't know how long you're supposed to take this to see beneficial results.
Posted by jparsell82 on November 16, 2009, at 21:32:31
In reply to day 6..., posted by TriedEveryDrug on November 15, 2009, at 18:09:19
I think this drug is better in conjunction with a stimulant... are you on one? Also, I don't think I would want to take any more than 2mg personally.
I took this from Rxlist:
"The recommended initial dose of guanfacine (as the hydrochloride) when given alone or in combination with another antihypertensive drug is 1 mg daily given at bedtime to minimize somnolence. If after 3 to 4 weeks of therapy, 1 mg does not give a satisfactory result, a dose of 2 mg may be given, although most of the effect of guanfacine is seen at 1 mg (see CLINICAL PHARMACOLOGY). Higher daily doses have been used, but adverse reactions increase significantly with doses above 3 mg/day."
The above paragraph is talking about Tenex(guanfacine immediate release) for blood pressure but still, they say the most effective dose is 1mg and no more than 2 is typically used. I'm just guessing, but I would think that would be similar to 2-4mg of Intuniv with 2mg possibly being more effective.
I think the higher you go on your dosage, the sleepier/weaker you're going to get plus the depression... I myself got depression from Propranolol. You don't want to block all of your adrenaline.
As far as kicking in, I'm not a doctor but i don't think it's one of those meds that take awhile to kick in. I think it's something you notice effects on right away, though they can build more over time.
> I have been ramping up from 1mg to 3mg. The max peds dose is 4mg, I calculate that in mg/kg, that would be closer to 11mg for adults, according to their mg/kg specifications on the prescribing sheet.
>
>
> anyhoo... I think this stuff is making me (more) depressed. I feel a bit confused sometimes, and anxious over things I don't get anxious about. Also quick to anger on this stuff (NRIs have this affect on me as well). I get very drowsy sometimes, too.
>
> Not seeing a whole lot of attentional benefit. Maybe a little.
>
> I don't know how long you're supposed to take this to see beneficial results.
Posted by TriedEveryDrug on November 16, 2009, at 22:53:46
In reply to Re: day 6..., posted by jparsell82 on November 16, 2009, at 21:32:31
Thanks... I have a bunch of adderall and Focalin kicking around, so I may try one of those with this tomorrow.
Can't hurt, though Adderall seems to make my add worse.
vee shall see...
Posted by Dr. Bob on November 24, 2009, at 2:42:42
In reply to Re: Anyone try Intuniv yet?, posted by JustWantToBeNormal on November 8, 2009, at 10:12:18
> It is an XR version of the drug guanfacine.
Please don't post under more than one name at the same time.
But please don't take this personally, either, this doesn't mean I don't like you or think you're a bad person, and I'm sorry if this hurts you.
More information about posting policies is in the FAQ:
http://www.dr-bob.org/babble/faq.html#names
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Thanks,
Bob
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