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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 13 of 13. This is the beginning of the thread.
Posted by FredPotter on November 8, 2009, at 18:18:18
So we keep bombarding this MAO-A and -B until we feel better or what? How much better? Parnate has made me feel worse, sleepy, weak, depressed, anxious, hardly able to walk because of sore stiff joints and locked back. I can't even get a plasma MAO-B level measured. MAO-A requires a spinal tap. Are the 2 correlated? Can we use the MAO-B level as an indicator of MAO-A? What happens if MAO-A is too low? Irritability, violence, self-harm, suicide? What on EARTH are we playing at?
Fred
Posted by Phillipa on November 8, 2009, at 18:46:37
In reply to When does MAO level become too low?, posted by FredPotter on November 8, 2009, at 18:18:18
Fred I don't know. So the parnate isn't working anymore for you? Love Phillipa
Posted by linkadge on November 8, 2009, at 19:05:14
In reply to When does MAO level become too low?, posted by FredPotter on November 8, 2009, at 18:18:18
Who knows. I personally think that MAO becomes low enough that sleep is disrupted and this is what produces the antidepressant effect.
I had all of the above with parnate + paranoid. It wasn't till I got off it that I realized how bad a drug it was. I was just so wisked away by the whole notion that it was a big gun. I was expecting something miraculus to kick in.
I should have got off it sooner.
Linkadge
Posted by FredPotter on November 8, 2009, at 21:21:14
In reply to Re: When does MAO level become too low?, posted by linkadge on November 8, 2009, at 19:05:14
> Who knows. I personally think that MAO becomes low enough that sleep is disrupted and this is what produces the antidepressant effect.
>
> I had all of the above with parnate + paranoid. It wasn't till I got off it that I realized how bad a drug it was. I was just so wisked away by the whole notion that it was a big gun. I was expecting something miraculus to kick in.
>
> I should have got off it sooner.
>
> LinkadgeThanks Linkadge. Yes I've been persuaded Parnate is a big gun. I took 40mg per day for 12 weeks until I could stand it no longer. Then I stopped. Now two days later I feel really well. Is that the way it works? Take it till you feel suicidal then stop and sort of drip feed the stuff?
Fred
Posted by FredPotter on November 8, 2009, at 21:54:55
In reply to Re: When does MAO level become too low?, posted by linkadge on November 8, 2009, at 19:05:14
Linkadge did you really have the painful stiff joints, almost unable to walk round the supermarket? If Parnate works then it sounds like a hospital drug not one for ambulatory patients. I spent every week slumped at my desk desperately fighting off sleep, at lunchtime was asleep in my car, then often I'd sleep all evening. I didn't get insomnia, only once when I took it in the evening. If they can't measure the MAO-A level they shouldn't be administering the drug surely. Then I'd sleep away my weekend. My friends were giving up on me because I never wanted to go out. Now I've stopped I feel quite well, if a little angry, but I'll speak to the psychopharmacologist on skype this evening
Fred
Posted by maxime on November 9, 2009, at 7:46:15
In reply to When does MAO level become too low?, posted by FredPotter on November 8, 2009, at 18:18:18
I had no idea that the Parnate made you feel so bad. Why do you continue to take it?
Posted by bulldog2 on November 9, 2009, at 9:12:35
In reply to When does MAO level become too low?, posted by FredPotter on November 8, 2009, at 18:18:18
> So we keep bombarding this MAO-A and -B until we feel better or what? How much better? Parnate has made me feel worse, sleepy, weak, depressed, anxious, hardly able to walk because of sore stiff joints and locked back. I can't even get a plasma MAO-B level measured. MAO-A requires a spinal tap. Are the 2 correlated? Can we use the MAO-B level as an indicator of MAO-A? What happens if MAO-A is too low? Irritability, violence, self-harm, suicide? What on EARTH are we playing at?
> FredI to stopped the drug after 8 weeks. Actually did not like the speedy effect after each dose. I was also impressed by the anecdotal accounts by some p-docs who claimed it was the no miss big gun. It seems many here have not had good results with this med. Yes I do realize many here are have trd. It can also really mess with your blood pressure. I would get spikes after each dose and after a few hours hypotension.
Posted by SLS on November 9, 2009, at 12:30:40
In reply to When does MAO level become too low?, posted by FredPotter on November 8, 2009, at 18:18:18
Discontinuing an MAOI can sometimes produce a temporary improvement.
- Scott
Posted by linkadge on November 10, 2009, at 18:07:46
In reply to Re: When does MAO level become too low?, posted by SLS on November 9, 2009, at 12:30:40
I had *unbelievable euphoria* after stopping parnate.
It was like a giant weight had been lifted off my shoulders. Like I was absolved of some horrible sin. I remember feeling perfectly well for almost a week or so med free.
I don't remember joint problems, but I do remember having really bad tachycardia and chest pain after each dose on just 40mg.
Linkadge
Posted by floatingbridge on November 10, 2009, at 19:13:30
In reply to When does MAO level become too low?, posted by FredPotter on November 8, 2009, at 18:18:18
Fred, so you're off it completely? And did you not have a trial of emsam as well (may I misremember)? Well, now that the big gun more than let you down, what do you think you might try next? are MAOIs out of the picture?
Sounds to me like you had a terrible reaction to it--I'm so sorry you had to suffer like that.
I don't follow the difference between the MAO-A level and MAO-B level--but I do not expect you to explain it to me. I just want you to feel better,
warm regards,
fb
Posted by Phillipa on November 10, 2009, at 19:59:45
In reply to Re: When does MAO level become too low? » FredPotter, posted by floatingbridge on November 10, 2009, at 19:13:30
Me either. Fred you were on the Maoi's for quite some time if my memory serves me at all. Love Phillipa
Posted by FredPotter on November 10, 2009, at 21:28:52
In reply to Re: When does MAO level become too low?, posted by Phillipa on November 10, 2009, at 19:59:45
Thanks everyone you're all so kind. I just take 75mg nortriptyline at night and after the 2 weeks washout of Parnate I'll introduce sertraline.
Yes Nardil was good to me eventually, but I put on weight and it interfered with sex. I may return to its waiting arms if all else fails.
I went for a walk at lunchtime and leaned on the bridge and watched the water flow by. Time for Poohsticks perhaps? I think the last 3-4 lines of the Pooh Sticks Chapter says it all. I'll check I've got it right and post it
Bless you all
Fred
Posted by FredPotter on November 10, 2009, at 21:41:43
In reply to Re: When does MAO level become too low?, posted by FredPotter on November 10, 2009, at 21:28:52
Not med related warning:::::
This might not be quite right:
After the game of Poohsticks, Pooh and Christopher Robin are left just gazing at the river flowing by.
Pooh: "Tigger's all right REALLY; I think everyone is REALLY, but I don't expect I'm right."
"Of course you are," said Christopher Robin
This is the end of the thread.
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