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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 24 of 24. This is the beginning of the thread.
Posted by Netch on February 25, 2009, at 9:22:52
Agomelatine Approved in EU for Major Depressive Episodes:
The European Commission has granted marketing authorisation for agomelatine (Valdoxan) for the treatment of adult patients with major depressive episodes.The approval is based on both short-term and long-term results from a large, comprehensive, international development programme including almost 6,000 adult patients with depression.
The results demonstrated the superior efficacy of agomelatine as compared with placebo, selective serotonin reuptake inhibitors (SSRIs), and serotonin noradrenaline reuptake inhibitor (SNRI) treatments.
Agomelatine was effective in moderately and severely depressed adult patients (18-65 years) presenting a first or recurrent episode of depression. Clinical improvement was seen within the first week of treatment, as reported by physicians and patients.
The drug was effective against all the core symptoms of depression including depressed mood, anxiety, feeling of guilt, psychomotor retardation, sleep disturbances, and daytime fatigue.
http://www.docguide.com/news/content.nsf/news/852571020057CCF68525756700800526
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Valdoxan granted authorisation for treatment of depressive episodes:
The European Commission has granted marketing authorisation for Servier's Valdoxan(R) /Thymanax(R) (agomelatine), the first melatonergic antidepressant for the treatment of adult patients with major depressive episodes.
Posted by Phillipa on February 25, 2009, at 11:35:52
In reply to Agomelatine Approved in EU, posted by Netch on February 25, 2009, at 9:22:52
Is it working for anyone who might be taking it here? Love Phillipa
Posted by brot on February 25, 2009, at 12:11:14
In reply to Agomelatine Approved in EU, posted by Netch on February 25, 2009, at 9:22:52
thank you for the information!
Posted by JayBTV2 on February 25, 2009, at 16:13:35
In reply to Agomelatine Approved in EU, posted by Netch on February 25, 2009, at 9:22:52
Wow thanks for the info! Been waiting for the official word.
So anyone know how long it'll be until it's on the market over there Europe?
Thanks!
-Jay
Posted by mbluett on February 25, 2009, at 20:43:55
In reply to Re: Agomelatine Approved in EU » Netch, posted by Phillipa on February 25, 2009, at 11:35:52
Phillipa, it only got approved on the 24th of February. How would anyone be taking it?
Posted by Maria3667 on February 26, 2009, at 3:55:20
In reply to Re: Agomelatine Approved in EU » Phillipa, posted by mbluett on February 25, 2009, at 20:43:55
Hi everyone,
My psy is willing to prescribe it to me. Going to ask my pharmacy how long it will be before it's actually available.
Keep ya updated!
> Phillipa, it only got approved on the 24th of February. How would anyone be taking it?
Posted by Extreme on February 26, 2009, at 6:06:57
In reply to Re: Agomelatine Approved in EU » mbluett, posted by Maria3667 on February 26, 2009, at 3:55:20
Im gonna try it as soon as it gets out in sweden, alreday have a deal with my doc, and thats in a few weeks from now last time i checked! I will probably write a very short report/note about how I experienced it.. could be usefull for some of you out there who like me gets all kinds of weird effects from substances affecting the brain. Im not gonna bet all my cards on this one but remembering back to the few times melatonin worked it sure would be amazing with a blast from the past :P
Posted by Netch on February 26, 2009, at 6:35:01
In reply to Re: Agomelatine Approved in EU » Netch, posted by Phillipa on February 25, 2009, at 11:35:52
I've read some have privately imported agomelatine from Ukraine where it's already available. Their experiences seem to be mixed. Some seem to embrace it others not.
Medical trials show that the success rate of Agomelatine is about the same as other AD but with lower side effects and improved sleep.
Posted by Extreme on February 26, 2009, at 12:04:32
In reply to Re: Agomelatine Approved in EU » Phillipa, posted by Netch on February 26, 2009, at 6:35:01
I wonder what happens if you take valdoxan some time during the day (as opposed to taking it before bedtime which you should do according to guidelines)? A melatonin-effect during the day... could that somehow be beneficial or just the opposite? Any ideas from someone?
Posted by Phillipa on February 26, 2009, at 19:39:10
In reply to Re: Agomelatine Approved in EU » Phillipa, posted by Netch on February 26, 2009, at 6:35:01
I heard it was a combo ad and antianxiety med. Oh it's being imported? love Phillipa
Posted by meltingpot on February 27, 2009, at 7:28:08
In reply to Agomelatine Approved in EU, posted by Netch on February 25, 2009, at 9:22:52
Hi,
Denise here from the uk, I used to post here a lot but have only lurked lately.
Please tell me that this drug won't just be like Remeron (I didn't respond well to) along with Melatonin as I've been having a really bad time lately with my depression and anxiety and looking for some hope.
Does anyone know?
Denise
Posted by Sigismund on February 27, 2009, at 17:30:35
In reply to Is this just not the same as Remeron + Melatonin, posted by meltingpot on February 27, 2009, at 7:28:08
>Please tell me that this drug won't just be like Remeron (I didn't respond well to) along with Melatonin as I've been having a really bad time lately with my depression and anxiety and looking for some hope.
It isn't. Truly.
Posted by desolationrower on February 28, 2009, at 3:45:42
In reply to Re: Is this just not the same as Remeron + Melatonin » meltingpot, posted by Sigismund on February 27, 2009, at 17:30:35
mirtazapine is pretty potent at 5ht2c but it does a number of other things as well
-d/r
Posted by meltingpot on February 28, 2009, at 12:43:59
In reply to Re: Is this just not the same as Remeron + Melatonin » meltingpot, posted by Sigismund on February 27, 2009, at 17:30:35
Hi Sigismund,
In what way is it different or any better?
How do you know?
Thanks.....Denise
Posted by Sigismund on February 28, 2009, at 13:25:03
In reply to To Sigismund, posted by meltingpot on February 28, 2009, at 12:43:59
I took Remeron twice, and twice only.
I'm not in a position where I can take stuff like that.
Agomelatine feels benign, and distinguishes itself among psychiatric drugs by not feeling like a pharmacological insult.
Posted by Sigismund on February 28, 2009, at 13:28:14
In reply to Re: To Sigismund » meltingpot, posted by Sigismund on February 28, 2009, at 13:25:03
So, you are going to ask, has it helped?
Yes.
How?
I find social situations much easier to deal with....I'm calmer, and can process the info better. I feel less vulnerable and feel like I have more skin around me. I've only been taking it for a couple of weeks.
Posted by ihatedrugs on March 1, 2009, at 0:37:11
In reply to Re: To Sigismund, posted by Sigismund on February 28, 2009, at 13:28:14
What about weight gain?
Posted by Sigismund on March 1, 2009, at 1:20:25
In reply to Re: To Sigismund, posted by ihatedrugs on March 1, 2009, at 0:37:11
>What about weight gain?
I've only been on it 2 weeks.
Too soon to tell, but I don't notice an increased desire to eat.
Posted by meltingpot on March 1, 2009, at 15:48:40
In reply to Re: To Sigismund » ihatedrugs, posted by Sigismund on March 1, 2009, at 1:20:25
Sigismund,
I didn't realise that you were on it. I'm not sure what it is you suffer from but does the drug seem to be helping at all?
Denise
Posted by meltingpot on March 1, 2009, at 15:54:10
In reply to Re: To Sigismund, posted by meltingpot on March 1, 2009, at 15:48:40
Sorry, ignore my last post, I've just seen your response about how you are feeling on it.
What oher meds have you tried in the past and how have they affected you?
I suffer from chronic anxiety (not social anxiety or phobias). Do you think it might help with that?
Denise
Posted by Sigismund on March 2, 2009, at 1:35:41
In reply to Re: To Sigismund, posted by meltingpot on March 1, 2009, at 15:54:10
>What oher meds have you tried in the past and how have they affected you?
Not SSRIs or TCAs
Benzos
Opiates
Melleril/Stellazine/Anatensol and the whole horrible bag.
The popular drugs were (naturally) the ones I enjoyed most.
>I suffer from chronic anxiety (not social anxiety or phobias).Well, I don't suffer from much anxiety as such (in seclusion).
Some (most?) people just give me the jerks, or I give myself the jerks around some people.
I take this to be a problem I have in processing social information into a set of rules I can follow, as I have no instinct for life :)
>Do you think it might help with that?There is an agomelatine anxiety thing (in the 6 hours before the evening dose perhaps), which I do not understand properly yet.
The really good thing about agomelatine is that it does not feel just bloody awful.
My first response was 'this is the psychotonic thing'.
I've always needed a tonic.Don't feel put off though.
Posted by meltingpot on March 2, 2009, at 11:50:26
In reply to Re: To Sigismund » meltingpot, posted by Sigismund on March 2, 2009, at 1:35:41
Thanks Sigismund, so are you saying that it doesn't seem to be a calming drug?
Denise
Posted by Sigismund on March 4, 2009, at 0:45:50
In reply to Re: To Sigismund, posted by meltingpot on March 2, 2009, at 11:50:26
>so are you saying that it doesn't seem to be a calming drug?
Yes and no.
To begin with it *was* calming (and clean).
After a couple of weeks I found myself, in the afternoon, feeling like I really really needed a drink and a Valium, so I have halved the dose for the moment.
Posted by Negcreep on March 5, 2009, at 7:33:56
In reply to Re: To Sigismund, posted by meltingpot on March 2, 2009, at 11:50:26
> Thanks Sigismund, so are you saying that it doesn't seem to be a calming drug?
>
> DeniseHi Denise, I have GAD and have been taking Agomelatine for about 4 months now. I started on the regular dose 25mg, and have since gone up to 50mg. The drug does have a good antidepressant anti-anxiety effect. However I think most people will need to take the higher dose of 50mg to get the most out of this drug. 25mg was ok but still had some anxiety symptoms (no panic attacks), 50mg has been a marked improvement on that, I think I may reach remission in the coming months.
Ago is much better than SSRI's for side effects. No/minimal sexual dysfunction, no increased appetite and much more balanced emotional state.
So far I'm very happy to be taking it.
Negcreep :)
This is the end of the thread.
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