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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 18 of 18. This is the beginning of the thread.
Posted by Michael Bell on January 26, 2009, at 23:36:45
Since some people on this board have participated in drug trials, I was wondering if anyone had experience with any of the SDNRIs (aka "triple reuptake inhibitors" that block reuptake of serotonin, norepinephrine, and dopamine) that are in phase II and phase III trials? If so, what were the effects? Thanks.
Posted by Vincent_QC on January 27, 2009, at 6:57:08
In reply to SNDRIs - Triple Reuptake Inhibitors, posted by Michael Bell on January 26, 2009, at 23:36:45
> Since some people on this board have participated in drug trials, I was wondering if anyone had experience with any of the SDNRIs (aka "triple reuptake inhibitors" that block reuptake of serotonin, norepinephrine, and dopamine) that are in phase II and phase III trials? If so, what were the effects? Thanks.
Look very interresting...and promising....a kind of MAOI, without food interractions...and probably less side-effects... You know the name of the molecule??? It will take 20 years before we get it in the Canada, if the trails work...hahaha ;-)Thanks!!!
Posted by Phillipa on January 27, 2009, at 11:47:53
In reply to Re: SNDRIs - Triple Reuptake Inhibitors, posted by Vincent_QC on January 27, 2009, at 6:57:08
Vincent they are didn't know that thanks. Phillipa
Posted by Vincent_QC on January 27, 2009, at 13:48:31
In reply to Re: SNDRIs - Triple Reuptake Inhibitors » Vincent_QC, posted by Phillipa on January 27, 2009, at 11:47:53
> Vincent they are didn't know that thanks. Phillipa
Hummm, what you mean Phillipa??? People participate in trails and don't know what they take??? A website with trails recrutments don't exist? I see this often...and normally they give at least the molecule numbers or the temporary name of it??? Strange... Anyway, it will be probably something with more specific action on the SE, NE and the DA...so less effienctly than the old MAOI, who hit everythings in the brains... That's my thoughts...negatives ones of course...cause today it's not a good day! hahaha ;-)
Posted by Phillipa on January 27, 2009, at 20:32:06
In reply to Re: SNDRIs - Triple Reuptake Inhibitors, posted by Vincent_QC on January 27, 2009, at 13:48:31
Vincemt didn't know like an MAOI. Sorry about your bad day too. Love Phillipa
Posted by sam K on January 27, 2009, at 23:38:29
In reply to Re: SNDRIs - Triple Reuptake Inhibitors » Vincent_QC, posted by Phillipa on January 27, 2009, at 20:32:06
I dont know if I'd like dopamine in my antidepressant because it seems to make me paranoid. aka wellbutrin
Posted by Vincent_QC on January 28, 2009, at 9:35:21
In reply to Re: SNDRIs - Triple Reuptake Inhibitors, posted by sam K on January 27, 2009, at 23:38:29
> I dont know if I'd like dopamine in my antidepressant because it seems to make me paranoid. aka wellbutrin
The Wellbutrin issue is somewhat a little bit strange...I first use it as a smooke aid cessation...it was call at the time Zyban...I remember that I was a lot anxious on it...too much in fact...it was very stimulant and I hated it because it worsed my social phobia and I Was working in a public field at the time, so I was unable to avoid public contact...So I never stop smooking with it and after 1 month I just throw the pills in the garbage...
Last fall, my PDoc add 300mg of Wellbutrin-SR in my Cipralex(Lexapro)regiment for adding some energy ...and strangely, I didin't feel anything, no energy, in fact it was worst...I had more daytime sedation with it than without it...
One thing is sure, as an AD and alone, it's not very efficiently for anxious people... and i'm not sure it's good... In a combo mix, some people have some improvements on their state...other not...
I think it's like this for every drugs on the Market...we are all different...some people tolerate more well a drug and others can't take it at all...So some drugs who act on the DA will make a strange effect to someone and another one will use the same drug with the same effect on the DA and feel something different...
I really think we canno't apply the same treatment technic to everyone, since we all react differently to drugs...
That's another mystery of life... ;-)
Posted by linkadge on January 29, 2009, at 8:48:40
In reply to Re: SNDRIs - Triple Reuptake Inhibitors » sam K, posted by Vincent_QC on January 28, 2009, at 9:35:21
Wellbutrin doesn't really have a strong effect on dopamine anyway.
Linkadge
Posted by desolationrower on January 29, 2009, at 12:17:08
In reply to Re: SNDRIs - Triple Reuptake Inhibitors, posted by linkadge on January 29, 2009, at 8:48:40
bupropion doesn't have much effect on norepinephrine either...
-d/r
Posted by Vincent_QC on January 29, 2009, at 13:17:39
In reply to Re: SNDRIs - Triple Reuptake Inhibitors, posted by linkadge on January 29, 2009, at 8:48:40
> Wellbutrin doesn't really have a strong effect on dopamine anyway.
>
> LinkadgeHumm so it's suppose to act on the DA and NE...what the hell it does if he dont act on them???? Just giving more anxiety??? hahaha
Posted by myco on January 29, 2009, at 14:25:03
In reply to SNDRIs - Triple Reuptake Inhibitors, posted by Michael Bell on January 26, 2009, at 23:36:45
Hey,
From my understanding Amoxapine (a tetracyclic antidepressant) acts as a SNDRI with a strong norepinephrine effect, weak seratonin effect and has a major metabolite that has dopamine blocking effect. I've never tried this med though so can't offer any personal experience but it's on my list.
keep smilin,
http://www.mentalhealth.com/drug/p30-a03.html
http://en.wikipedia.org/wiki/Amoxapine
atypical depression, gad, social anxiety
75mg nardil
Posted by linkadge on January 29, 2009, at 19:39:13
In reply to AMOXAPINE is technically a SNDRI (i think?), posted by myco on January 29, 2009, at 14:25:03
I though the dopamine activity refered to dopamine receptor antagonism i.e. neuroleptic style.
Even at clinical doses, wellbutrin has very low activity as a dopamine transport inhibitor. I remmber reading as study that suggested at a dose of 300mg, it only inhibited the dopamine transporter by ~15%.
Wellbutrin has an effect on norepinephrine reuptake and also norepinephrine release. Some modern research has theorized that it is working via norepinephrine release.
Linkadge
Posted by myco on January 29, 2009, at 21:20:54
In reply to SNDRIs - Triple Reuptake Inhibitors, posted by Michael Bell on January 26, 2009, at 23:36:45
oops, my bad
:-)
Posted by yxibow on January 30, 2009, at 10:48:55
In reply to Re: SNDRIs - Triple Reuptake Inhibitors, posted by linkadge on January 29, 2009, at 8:48:40
> Wellbutrin doesn't really have a strong effect on dopamine anyway.
>
> LinkadgeIt's not an amphetamine but I can attest that it was for me at least a very wired agent that aggravated OCD in the end, and yes, as a bonus boosted my sex drive fairly substantially, as a result of dopamine changes I'm sure.
It is somewhat related to Tenuate, diethylproprion.
-- Jay
Posted by SLS on January 30, 2009, at 12:08:53
In reply to Re: SNDRIs - Triple Reuptake Inhibitors » linkadge, posted by yxibow on January 30, 2009, at 10:48:55
Sheldon H. Preskorn, MD, is convinced that what "small" amount of DA reuptake inhibition Wellbutrin produces is still large enough to have clinical effects. He feels the same way about its dimunitive NE reuptake inhibition as well
I don't know what to think.
- Scott
Posted by SLS on January 30, 2009, at 12:12:01
In reply to Re: SNDRIs - Triple Reuptake Inhibitors, posted by SLS on January 30, 2009, at 12:08:53
> Sheldon H. Preskorn, MD, is convinced that what "small" amount of DA reuptake inhibition Wellbutrin produces is still large enough to have clinical effects. He feels the same way about its dimunitive NE reuptake inhibition as well
>
> I don't know what to think.
I will say this, though. Wellbutrin consistently makes my depression significantly worse. However, I responded robustly, although briefly, to nomifensine (Merital), a potent DA and NE reuptake inhibitor.
- Scott
Posted by Vincent_QC on January 31, 2009, at 10:40:45
In reply to Re: SNDRIs - Triple Reuptake Inhibitors, posted by SLS on January 30, 2009, at 12:12:01
> > Sheldon H. Preskorn, MD, is convinced that what "small" amount of DA reuptake inhibition Wellbutrin produces is still large enough to have clinical effects. He feels the same way about its dimunitive NE reuptake inhibition as well
> >
> > I don't know what to think.
>
>
> I will say this, though. Wellbutrin consistently makes my depression significantly worse. However, I responded robustly, although briefly, to nomifensine (Merital), a potent DA and NE reuptake inhibitor.
>
>
> - Scott
>Just the brand name "Wellbutrin or Zyban" give me headache and anxiety!!! lol I hate that drug...Worse my depression and my social anxiety and never help me to stop smooking...in fact, I always smooke more when I Was on it...it had the inverse effect on me...
Posted by West on February 3, 2009, at 20:59:40
In reply to Re: SNDRIs - Triple Reuptake Inhibitors, posted by Vincent_QC on January 31, 2009, at 10:40:45
Bupropion. An antidepressant, also a stimulant and an appetite suppressant. Gets the blood pumping. I have no memory of my time on it in the 3 months or so I was taking it. It must have been some help because i wanted to continue taking it but was declined >> << My fear is that whilst on it I had no buffering effect on my behaviour - perhaps becoming a little manic ? I cannot judge but as a naturally melancholic type any positivity or energy is to be encouraged. I wanted more. MORE.
The key with it seems to be the 4-6 week response window around which time you'll know if it's working as an adjunct, which is what it is most commonly used for. Not to undermine it's reputation, but a drug is a drug like any other -
Naturally psychiatrists need a reality check- by this i mean medicine has to be understood (by them) since they're not giving the drugs trials themselves a healthy level of what works wins should be exercised
This is the end of the thread.
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