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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by KimStereo on November 6, 2008, at 15:40:22
Getting ready to try Stablon after terrible experience with a few different SSRI's. Does anyone have experience with this medicine ? If so, can you explain how it works. If it enhaces the reuptake of Serotonin, doesn't that mean there is less in the synaptic cleft ? Everything I've read is that the action is outside of the cell. If Stablon enables more Serotonin into the cell, than how does it work?
Also, does anyone know what the washout period should be before switching from an SSRI to an SSRE ? My doctor says there doesn't need to be any, but that wouldn't seem to make sense either. I just stopped Paxil 4 days ago and having terrible withdrawal (brain zaps, nausea, etc.). I'm going to wait a few days before starting the Stablon.
Posted by dapper on November 6, 2008, at 16:16:45
In reply to Anyone have any experience with Stablon,Tianeptine, posted by KimStereo on November 6, 2008, at 15:40:22
You don't need to worry about the washout. I took my stablon while I weaned off effexor for a couple weeks. Sorry to say, the stablon did not work for me. I would take 4 pills a day at times, but I might as well have taken a tic tac, cause I really didn't receive much benefit from it. I am now on nefazodone, and am feeling more and more better as I climb to my target dose. Everyone does respond different though, so best of luck in your trials. I know the pain all too well, I felt like I was about to crack until the nef. started kicking in.
Posted by bleauberry on November 6, 2008, at 17:49:59
In reply to Anyone have any experience with Stablon,Tianeptine, posted by KimStereo on November 6, 2008, at 15:40:22
Some people do great with stablon. It has even done ok in treatment resistant cases. But as with everything else, it doesn't work for everyone. Some people here over the years have really liked it and had no side effects, while others didn't like it or had side effects they didn't expect.
The longest I was on it was about a week. The very first dose lifted my depression about 70% and it was unbelievable. After that it seemed to fade and I got more and more blue, dazed, and out of it as each day went by. I remember a couple people here a few months ago that said it worked ok for them except that they had unbearable anxiety from it, even though stablon is supposed to be good for anxiety. Even in recent posts right on this very page a couple people mentioned what a good anxiety med stablon is.
I was feeling really blue today and took one dose of stablon. It lifted my spirits about 50% within 2 hours. Then it was followed by very uncomfortable anxiety that had not existed prior, and I lost all appetite.
It can be a great med. Side effects compared to other meds are generally a lot less. Don't let any negative experiences worry you, because they happen with all meds. Focus on the positives that were shown in many clinical trials.
There is no need for a washout. I even remember reading a case study on pubmed where a lady failed a conventional antidepressant, and failed stablon, but improved significantly when they were combined. No mention though what that other antidepressant was.
Don't worry about figuring out the mechanics of how stablon works. No one even knows how any of these meds work. The best they can do is pose theories, or to infer what happens based on what happened with lab rats, which have brains and blood brain barriers that are not the same as humans. Just because a drug does something in a rat's brain doesn't necessarily mean that is what happens with a human. Stablon has been shown to reduce circulating plasma serotonin and norepinephrine immediately, but increases serotonin within cells.
I think the serotonin thing is way too simplistic. These meds act on genes and all kinds of hidden things besides the neurotransmitters they are aimed at. Among other things, one of tianeptine's primary supposed modes of action is to restore brain plasiticity. That is, the brain's ability to adjust and respond to various conditions such as stress.
Sorry about the paxil withdrawals. Been there, done that. I weaned very slow in tiny steps over a long time and it was actually not bad. My main withdrawal after it was finally all done was some weird dizziness, almost like I was floating instead of walking. And some minor brain zaps. All these things do pass. I don't know if tianeptine would help or not, but if you want to there is not really any need to wait unless that is what you are more comfortable doing.
Posted by Tomatheus on November 7, 2008, at 3:17:08
In reply to Anyone have any experience with Stablon,Tianeptine, posted by KimStereo on November 6, 2008, at 15:40:22
KimStereo,
Here's a link to a post of mine in which I described my experience with tianeptine:
http://www.dr-bob.org/babble/20080926/msgs/855970.html
Tomatheus
Posted by Maria3667 on November 7, 2008, at 6:59:51
In reply to Anyone have any experience with Stablon,Tianeptine, posted by KimStereo on November 6, 2008, at 15:40:22
Hi Kim,
Tianeptine definately worked for my depression. But the downside was I got extreme anxiety.
I'm not sure how Tianeptine works, but I'm guessing it upregulates serotonine and thus has a by effect on dopamine, which it increases also.
After about 4 weeks use, it made me extremely scared. Also got a little weight gain.
I always seem to get adverse effects whilst on SSRI's... so after many trials and errors I'm keeping well away from them. Ofcourse you may not get these effects. I hope it works for you.
My best!
Maria> Getting ready to try Stablon after terrible experience with a few different SSRI's. Does anyone have experience with this medicine ? If so, can you explain how it works. If it enhaces the reuptake of Serotonin, doesn't that mean there is less in the synaptic cleft ? Everything I've read is that the action is outside of the cell. If Stablon enables more Serotonin into the cell, than how does it work?
>
> Also, does anyone know what the washout period should be before switching from an SSRI to an SSRE ? My doctor says there doesn't need to be any, but that wouldn't seem to make sense either. I just stopped Paxil 4 days ago and having terrible withdrawal (brain zaps, nausea, etc.). I'm going to wait a few days before starting the Stablon.
Posted by elanor roosevelt on November 8, 2008, at 0:54:09
In reply to Re: Anyone have any experience with Stablon,Tianeptine » KimStereo, posted by Maria3667 on November 7, 2008, at 6:59:51
I found tianptine to be a prosocial lift sometimes
found it more useful as a sometimes med
made me kind of teary after the first weekother side effects eliminated it
it's an immediate lift
works great for some people
good luck
Posted by desolationrower on November 11, 2008, at 19:36:06
In reply to Re: Anyone have any experience with Stablon,Tianeptine, posted by elanor roosevelt on November 8, 2008, at 0:54:09
for me it basically made the world seem more like i was actually living in it. really opposite of the fog ssris cause. however didn't help my anxiety which is my real problem.
-d/r
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