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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by bleauberry on January 9, 2008, at 18:03:52
Curious about Ensam. When it came out I was a total skeptic because a whole bunch of people who jumped on it were disappointed at the results. But now I am taking a second look.
With half a patch (3mg) is it an MAOI of serotonin, norepinephrine, and dopamine? Or just one or two of those?
How about at 6mg?
How about at 9mg?
I've tried deprenyl liquid and pill a couple times. The pill felt good immediately, an obvious flood of norepinephrine and dopamine. But rapid poopout in just days. Followed by what I would say was borderline paranoia. Had to stop. Tried liquid at 1mg first day 2 drops second day. Good energy boost, slight mood help, but obvious irritation. Someone even said "You don't have to get mad about it" even when I had no idea I was acting that way. So I have obvious reservations about this drug.
But I have also seen a couple clinical reports where it was obvious that Ensam worked differently than oral deprenyl. One person who did not respond to deprenyl at any dose did respond completely to Ensam. This is where I regained new interest in the drug.
Tell me all you can about it. Interested.
Posted by ny2bk on January 9, 2008, at 18:34:08
In reply to Tell Me More About Ensam, posted by bleauberry on January 9, 2008, at 18:03:52
> Curious about Ensam. When it came out I was a total skeptic because a whole bunch of people who jumped on it were disappointed at the results. But now I am taking a second look.
>
> With half a patch (3mg) is it an MAOI of serotonin, norepinephrine, and dopamine? Or just one or two of those?
>
> How about at 6mg?
>
> How about at 9mg?
>
> I've tried deprenyl liquid and pill a couple times. The pill felt good immediately, an obvious flood of norepinephrine and dopamine. But rapid poopout in just days. Followed by what I would say was borderline paranoia. Had to stop. Tried liquid at 1mg first day 2 drops second day. Good energy boost, slight mood help, but obvious irritation. Someone even said "You don't have to get mad about it" even when I had no idea I was acting that way. So I have obvious reservations about this drug.
>
> But I have also seen a couple clinical reports where it was obvious that Ensam worked differently than oral deprenyl. One person who did not respond to deprenyl at any dose did respond completely to Ensam. This is where I regained new interest in the drug.
>
> Tell me all you can about it. Interested.At the lower spectrum of dose it is mostly a maoi-b drug which acts primary on dopamine/noradrealine and also pea.
The liquid seprenyl i.e deprenyl to me was great at this,it will cause over stimulation then agigtaion,but i found it had a extreme synergy with a mg of klonopin.
If the dose is raised,i believe it then becomes a med more like parnate,where alhough it still has high affinity for dopamine,making it more stimulant then say nardil,it is however no longer a islolated maoi b drug,and rather a maoi a and b which means it affects a wider spectrum of chemials including ones that can cause interactions as well as maoi i believe no longer makes it direct to the brain but rather a whole body effect making it more of a possable danger.
All an all its probuvably a more potent,more cleaner but similiar effect to parnate,where as nardil due to its general effect of raising natural gaba levels will remain a unique maoi.
Posted by former trx resistant on January 9, 2008, at 22:43:56
In reply to Tell Me More About Ensam, posted by bleauberry on January 9, 2008, at 18:03:52
Please read all the posts, many threads about EMSAM success stories. It doesn't cause irriation, if anything if causes my my significant other irritation because I got my life back after 9 years of hell and I'm happy so I don't put up with stuff I shouldn't have, in the first place. It you have too much, maybe a bit euphoric. But I'm unipolar treatment resistant major depression. So I needed more than a stick of dynamite to get me out of the apartment and out in life. After 2 months I can't believe how happy and grateful I am for every day. I don't think any bi-polar people should go near it. You can regulate the dose by halfing the 6mg and not wearing 24 hours as directed. Must try on for your brain chemicals.
Posted by Phillipa on January 9, 2008, at 23:42:40
In reply to Re: Tell Me More About Ensam, posted by ny2bk on January 9, 2008, at 18:34:08
Thanks didn't know that but no anxiety relief wouldn't the dose that minics nardil help anxiety? I really still love the idea of a patch psychologically take it off it's gone know the drug stay in your system but I'd think it was gone. Phillipa you sure know your meds
Posted by former trx resistant on January 10, 2008, at 0:26:39
In reply to Re: Tell Me More About Ensam » ny2bk, posted by Phillipa on January 9, 2008, at 23:42:40
It is gone faster because it's transdermal. therefore it does not pass through gut. As transdermal, you get very slow, very tiny amounts directly into blood. If you feel too anxious, you take it off and within 1 to 1 1/2 your not anxious.
Posted by ny2bk on January 10, 2008, at 8:18:27
In reply to Re: Tell Me More About Ensam » ny2bk, posted by Phillipa on January 9, 2008, at 23:42:40
> Thanks didn't know that but no anxiety relief wouldn't the dose that minics nardil help anxiety? I really still love the idea of a patch psychologically take it off it's gone know the drug stay in your system but I'd think it was gone. Phillipa you sure know your meds
It can be easly balanced as far as anxiety with what i beleve is the most synergetic benzo with deprenyl and that is klonopin,why i dont know.
However no,alone it will likly eventualy for most create anxiety as do most anti depressants,nardil is a unique drug as its mechanism of action partly creates or increases overall gaba production,so the anxiety relieaf of nardil will be unique here to maois or any med.
Emsam unless one is not subject to anxiety or is simply a exception as there always is,will eventualy as it accumaltes lower gaba and require some form of additonal benzo or anxiety med to go along with it,i believe if this is addressed at the start more people might have success with the drug.
Posted by Phillipa on January 10, 2008, at 22:19:41
In reply to Re: Tell Me More About Ensam, posted by ny2bk on January 10, 2008, at 8:18:27
Excellent thought and great idea. Phillipa
This is the end of the thread.
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