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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 4 to 28 of 28. Go back in thread:
Posted by Justherself54 on December 26, 2007, at 15:19:46
In reply to Re: Discontinued?, posted by Justherself54 on December 26, 2007, at 15:04:45
I've been doing some googling and it seems like some of the online pharmacies are discontinuing distributing it..probably because there's not a big market for it..but I can't find anything else showing it's not been manufactured anymore..
Posted by Larry Hoover on December 26, 2007, at 16:23:17
In reply to Discontinued?, posted by Phoenix1 on December 26, 2007, at 14:46:16
> A hospital pharmacist just told me that she thought it was discontinued in Canada. Can anyone confirm?
Well, there's nothing to that effect on the Health Canada website, or the Erfa website. Not that I found, anyway.
Here's the contact list for the company. Why don't you give them a ring on the 800 number?
http://www.erfa-sa.com/Nardil/english/contact_en.html
Lar
Posted by Phoenix1 on December 26, 2007, at 17:12:47
In reply to Re: Discontinued? » Phoenix1, posted by Larry Hoover on December 26, 2007, at 16:23:17
Hi Larry, Justherself,
Thanks for the info, it's encouraging. Maybe it'd just a supply shortage. I'm a little desperate. I've jumped through SO many hoops to get to this point including re-trying 2 AD's that previously didn't work, a long "wash-out" period followed by 2 weeks "practicing" the MAOI diet. Now, everything is finally in place and I can't get the Nardil. I've been about a month off of all AD's and am not doing too well. I hope I find a Nardil source, as I see it as my last hope... Thanks again for the quick responses.
Phoenix1
Posted by Justherself54 on December 26, 2007, at 17:50:19
In reply to Nardil in Canada, posted by Phoenix1 on December 26, 2007, at 14:23:54
Try calling back some of the pharmacies..most don't have it in stock but they should be able to order it in..by the next day..when I was in a trip in the city I had forgotten to pack my Nardil..I had no trouble getting a pharmacy to get in it for me the same day..sounds like maybe you've been getting the "run around" by some pharmacies that don't want to go the extra mile to special order it in..keep trying..you'll find one!
Posted by Phoenix1 on December 26, 2007, at 17:54:51
In reply to Re: Nardil in Canada, posted by Justherself54 on December 26, 2007, at 17:50:19
Hi Again Justherself,
I called at least 30 pharmacies today. None had stock and all of them gave me the same story. "The distributors are out of stock because the manufacturer is unable to supply". A little cryptic. Only 2 local hospitals stock it, but will only dispense to inpatients. Sigh... I left a message w/ ERFA and emailed them too. Hopefully, I'll be able to speak to a live person there tomorrow. Thanks again for your help though.
Phoenix1
> Try calling back some of the pharmacies..most don't have it in stock but they should be able to order it in..by the next day..when I was in a trip in the city I had forgotten to pack my Nardil..I had no trouble getting a pharmacy to get in it for me the same day..sounds like maybe you've been getting the "run around" by some pharmacies that don't want to go the extra mile to special order it in..keep trying..you'll find one!
Posted by Phoenix1 on December 27, 2007, at 8:40:29
In reply to Re: Discontinued? » Phoenix1, posted by Larry Hoover on December 26, 2007, at 16:23:17
OK, I just got a hold of a rep at ERFA, and they have just underproduced, and won't have any avaialable for 3 weeks, followed by a one week distributor lag. So it looks like I'll be waiting at least another month to start Nardil. I was so hoping to start it sooner. Oh well... Thanks again for your help Justherself, Larry.
Phoenix1 = a bit demoralized.
> > A hospital pharmacist just told me that she thought it was discontinued in Canada. Can anyone confirm?
>
> Well, there's nothing to that effect on the Health Canada website, or the Erfa website. Not that I found, anyway.
>
> Here's the contact list for the company. Why don't you give them a ring on the 800 number?
>
> http://www.erfa-sa.com/Nardil/english/contact_en.html
>
> Lar
>
Posted by Justherself54 on December 27, 2007, at 10:46:32
In reply to Re: Discontinued?, posted by Phoenix1 on December 27, 2007, at 8:40:29
I just talked to my pharmacist..they called their distributor and there were only 2 bottles left, so he scooped them..I'm very concerned that a lot of people who are on Nardil are going to have to suffer immediate withdrawal as they won't be able to get their script filled!
> OK, I just got a hold of a rep at ERFA, and they have just underproduced, and won't have any avaialable for 3 weeks, followed by a one week distributor lag. So it looks like I'll be waiting at least another month to start Nardil. I was so hoping to start it sooner. Oh well... Thanks again for your help Justherself, Larry.
>
> Phoenix1 = a bit demoralized.
>
> > > A hospital pharmacist just told me that she thought it was discontinued in Canada. Can anyone confirm?
> >
> > Well, there's nothing to that effect on the Health Canada website, or the Erfa website. Not that I found, anyway.
> >
> > Here's the contact list for the company. Why don't you give them a ring on the 800 number?
> >
> > http://www.erfa-sa.com/Nardil/english/contact_en.html
> >
> > Lar
> >
>
>
Posted by Phoenix1 on December 27, 2007, at 10:54:03
In reply to Re: Nardil Underproduced-what now?, posted by Justherself54 on December 27, 2007, at 10:46:32
Yes, it's definitely more of a concern for Canadians already on Nardil. I'm very glad your pharmacist was able to secure a supply for you, that must be reassuring. By the time that runs out, I'm sure ERFA will be resupplying their distributors and you won't have a problem. A treatment interruption could have serious consequences, as I'm sure everyone is aware.
For a new patient, desperately wanting to start Nardil, it is just very annoying, and depressing. A potential treatment exists, but I can't get my hands on it. In the mean time, that means no AD's for me, for a total of at least 2 months of washout, diet "practice", and non-supply issues.
In that time my depression has only worsened... I don't want to try Parnate (Which is available) because I have a lot of anxiety too, so Nardil is clearly the better choice. Very very frustrating, demoralizing, and fuel for the depression. Sometimes I just want to give up, as it seems the obstacles are too difficult to overcome.
Phoenix1
> I just talked to my pharmacist..they called their distributor and there were only 2 bottles left, so he scooped them..I'm very concerned that a lot of people who are on Nardil are going to have to suffer immediate withdrawal as they won't be able to get their script filled!
>
> > OK, I just got a hold of a rep at ERFA, and they have just underproduced, and won't have any avaialable for 3 weeks, followed by a one week distributor lag. So it looks like I'll be waiting at least another month to start Nardil. I was so hoping to start it sooner. Oh well... Thanks again for your help Justherself, Larry.
> >
> > Phoenix1 = a bit demoralized.
> >
> > > > A hospital pharmacist just told me that she thought it was discontinued in Canada. Can anyone confirm?
> > >
> > > Well, there's nothing to that effect on the Health Canada website, or the Erfa website. Not that I found, anyway.
> > >
> > > Here's the contact list for the company. Why don't you give them a ring on the 800 number?
> > >
> > > http://www.erfa-sa.com/Nardil/english/contact_en.html
> > >
> > > Lar
> > >
> >
> >
>
>
Posted by Phoenix1 on December 27, 2007, at 10:55:20
In reply to Re: Nardil Underproduced-what now?, posted by Justherself54 on December 27, 2007, at 10:46:32
Oh, and by the way, the ERFA rep says it's not uncommon for this to happen at this time of year for whatever reason. Plan for it next year if necessary!
Phoenix1
Posted by Justherself54 on December 27, 2007, at 11:32:38
In reply to Re: Nardil Underproduced-what now? » Justherself54, posted by Phoenix1 on December 27, 2007, at 10:54:03
I was on parnate before but discontinued it and started Nardil because of bad chills (which I found out later weren't from the parnate) but from a long recovery from surgery..both gave me increased focus and concentration..I don't have the hypotension problems as much on Nardil but my sleep was WAY better on parnate (I have terrible insomnia on Nardil)..both worked great for anxiety and both worked for my depression..both worked for increased socialization..so if you feel you are sinking fast maybe a trial of Parnate might be something to consider..
Posted by Phoenix1 on December 27, 2007, at 11:48:41
In reply to Re: Parnate available-Phoenix1, posted by Justherself54 on December 27, 2007, at 11:32:38
I'll definitely ask my psychiatrist about that today at my appointment. I was just worried because I had heard that it heightened many peoples anxiety. Interesting that your insomnia was worse on Nardil than on Parnate. I'd always heard the reverse was more common. I already have insomnia quite badly, so it will be interesting to see how much worse it gets on an MAOI. 75mg of Seroquel and 30mg of Oxazepam barely touches the insomnia and still only allows me ~4 hours of sleep. And that's on top of clonazepam for daytime anxiety. I'm a bit of a mess right now, but still managing to hold things together for the meantime.
Anyways, thanks for the Parnate suggestion. I really do appreciate all your input.
Phoenix1
Posted by Justherself54 on December 27, 2007, at 12:07:20
In reply to Re: Parnate available-Phoenix1 » Justherself54, posted by Phoenix1 on December 27, 2007, at 11:48:41
I've already had to increase my seroquel and take clonazapam and zopiclone at bed too..insomnia is no fun! Hope your pdoc comes up with something for you..a month is too long to wait when you're sinking fast..keep us posted!
> I'll definitely ask my psychiatrist about that today at my appointment. I was just worried because I had heard that it heightened many peoples anxiety. Interesting that your insomnia was worse on Nardil than on Parnate. I'd always heard the reverse was more common. I already have insomnia quite badly, so it will be interesting to see how much worse it gets on an MAOI. 75mg of Seroquel and 30mg of Oxazepam barely touches the insomnia and still only allows me ~4 hours of sleep. And that's on top of clonazepam for daytime anxiety. I'm a bit of a mess right now, but still managing to hold things together for the meantime.
>
> Anyways, thanks for the Parnate suggestion. I really do appreciate all your input.
>
> Phoenix1
Posted by Phoenix1 on December 27, 2007, at 19:42:56
In reply to Re: Parnate available-Phoenix1, posted by Justherself54 on December 27, 2007, at 12:07:20
FYI, I finally found some Nardil at an obscure distant pharmacy. On my way to pick it up tonight! Finally, some good luck.
Phoenix1
Posted by Justherself54 on December 27, 2007, at 21:58:14
In reply to I Found some Nardil!, posted by Phoenix1 on December 27, 2007, at 19:42:56
> FYI, I finally found some Nardil at an obscure distant pharmacy. On my way to pick it up tonight! Finally, some good luck.
>
> Phoenix1All right! Good news..hope it works well for you!
Posted by mav27 on December 28, 2007, at 0:34:33
In reply to Re: Parnate available-Phoenix1 » Justherself54, posted by Phoenix1 on December 27, 2007, at 11:48:41
> Interesting that your insomnia was worse on >Nardil than on Parnate. I'd always heard the >reverse was more common.
>
> Phoenix1I thought insomnia couldn't get worse than when i was on parnate... boy was i wrong.. nothing will ever compare to how bad Nardil caused me insomnia when i was on it recently.
Posted by Phoenix1 on December 28, 2007, at 8:39:48
In reply to Re: Parnate available-Phoenix1 » Phoenix1, posted by mav27 on December 28, 2007, at 0:34:33
Yikes, that's not good to hear. On the other hand, I've now heard the full spectrum of how people respond to Nardil so I will just have to wait and see how it affects me. My pdoc started me on an escalating dose: 15mg for 3 days, 30mg for 3 days, 45mg for a week, then 60mg for a week. The end goal depending on how I respond is 1mg/kg, per published literature. That would mean a 90mg dose. My insomnia is already bad, and my pdoc is tapering me off benzos completely, so I don't know what to expect. I have very high hopes that Nardil will help me. My only previous MAOI experience with Moclobemide was a huge but very short lived success.
BTW, any ideas on how to prevent the dreaded Nardil poop-out before it happens? Is their a medical term for "poop-out" for lit searches?
Thanks,
Phoenix1
> > Interesting that your insomnia was worse on >Nardil than on Parnate. I'd always heard the >reverse was more common.
> >
> > Phoenix1
>
> I thought insomnia couldn't get worse than when i was on parnate... boy was i wrong.. nothing will ever compare to how bad Nardil caused me insomnia when i was on it recently.
Posted by Justherself54 on December 28, 2007, at 9:52:44
In reply to Re: Parnate available-Phoenix1 » mav27, posted by Phoenix1 on December 28, 2007, at 8:39:48
It took a few weeks for the insomnia to really manifest itself. Will your pdoc let you hold on to one benzo for bedtime? I hope the insomnia doesn't happen, but I think more often than not it does. My pdoc and I decided to try MAOI's, hoping to get more than 6 months or a year at best as every single med has pooped out on me..when I see people post on here that have been on it for 20 years with no poop out, it gives me hope.
I don't know the medical term for poop out, other than I think it might be called serotonin fatigue and I found another term on the web called tachyphylaxis. Good luck to you!
> Yikes, that's not good to hear. On the other hand, I've now heard the full spectrum of how people respond to Nardil so I will just have to wait and see how it affects me. My pdoc started me on an escalating dose: 15mg for 3 days, 30mg for 3 days, 45mg for a week, then 60mg for a week. The end goal depending on how I respond is 1mg/kg, per published literature. That would mean a 90mg dose. My insomnia is already bad, and my pdoc is tapering me off benzos completely, so I don't know what to expect. I have very high hopes that Nardil will help me. My only previous MAOI experience with Moclobemide was a huge but very short lived success.
>
> BTW, any ideas on how to prevent the dreaded Nardil poop-out before it happens? Is their a medical term for "poop-out" for lit searches?
>
> Thanks,
>
> Phoenix1
>
> > > Interesting that your insomnia was worse on >Nardil than on Parnate. I'd always heard the >reverse was more common.
> > >
> > > Phoenix1
> >
> > I thought insomnia couldn't get worse than when i was on parnate... boy was i wrong.. nothing will ever compare to how bad Nardil caused me insomnia when i was on it recently.
>
>
Posted by Jedi on December 31, 2007, at 2:38:33
In reply to Re: Parnate available-Phoenix1, posted by Justherself54 on December 28, 2007, at 9:52:44
Hi,
Nardil has kept my major depression away for most of the past eleven years. I've stopped it four times for trials of newer meds with maybe less side effects. Each time this has resulted in the return of my major depression. Major side effects that are still with me; weight gain, insomnia(treated with Seroquel), presbyopia, delayed orgasm, and daytime somnolence. I will live with these over major depression. Each of my major depressions has been life threating.You are right. The medical term for "poop out" is tachyphylaxis.
Take care,
Jedi
Medical Dictionary - tachyphylaxis
Definition:
Rapid appearance of progressive decrease in response to a given dose after repetitive administration of a pharmacologically or physiologically active substance.
------------------------------------------
> It took a few weeks for the insomnia to really manifest itself. Will your pdoc let you hold on to one benzo for bedtime? I hope the insomnia doesn't happen, but I think more often than not it does. My pdoc and I decided to try MAOI's, hoping to get more than 6 months or a year at best as every single med has pooped out on me..when I see people post on here that have been on it for 20 years with no poop out, it gives me hope.
>
> I don't know the medical term for poop out, other than I think it might be called serotonin fatigue and I found another term on the web called tachyphylaxis. Good luck to you!
>
>
> > Yikes, that's not good to hear. On the other hand, I've now heard the full spectrum of how people respond to Nardil so I will just have to wait and see how it affects me. My pdoc started me on an escalating dose: 15mg for 3 days, 30mg for 3 days, 45mg for a week, then 60mg for a week. The end goal depending on how I respond is 1mg/kg, per published literature. That would mean a 90mg dose. My insomnia is already bad, and my pdoc is tapering me off benzos completely, so I don't know what to expect. I have very high hopes that Nardil will help me. My only previous MAOI experience with Moclobemide was a huge but very short lived success.
> >
> > BTW, any ideas on how to prevent the dreaded Nardil poop-out before it happens? Is their a medical term for "poop-out" for lit searches?
> >
> > Thanks,
> >
> > Phoenix1
> >
> > > > Interesting that your insomnia was worse on >Nardil than on Parnate. I'd always heard the >reverse was more common.
> > > >
> > > > Phoenix1
> > >
> > > I thought insomnia couldn't get worse than when i was on parnate... boy was i wrong.. nothing will ever compare to how bad Nardil caused me insomnia when i was on it recently.
> >
> >
>
>
Posted by Justherself54 on December 31, 2007, at 7:49:34
In reply to Re: Parnate available-Phoenix1 » Justherself54, posted by Jedi on December 31, 2007, at 2:38:33
How much seroquel do you take at night? I'm currently taking 50 mg., .5 mg clonazapam and 7.5 zopicone..one would think that would get me through a good part of the night, but I continue to have frequent wakenings and always seem to be just on the "edge" of deep sleep..I can't take trazodone..
It's a strange feeling, after I take my night meds, they hit pretty hard, but once I'm in bed, the tossing and turning begins..I'm wondering if increasing the seroquel will help..I'm reluctant to make another increase tho..any thoughts?
And have a Happy New Year!
Posted by Phoenix1 on December 31, 2007, at 9:52:08
In reply to Re: Parnate available-Phoenix1 » Justherself54, posted by Jedi on December 31, 2007, at 2:38:33
Hi Jedi,
Thanks for the answer... tachyphylaxis! Glad to hear you are doing well on Nardil. I have high hopes that it will be the answer for me too. I'm not sure what my doctor will let me stay on for the insomnia. He doesn't like the Seroquel, as he doesn't think it's a good long term sleep med. On the other hand, I have had issues with benzo tolerance and dependance, so he is wary there too. But I need to sleep!
Can I ask you some questions? How long did it take for the Nardil to "kick in" for you, and what dosage did it kick in at? What dosage are you on now? How much Seroquel do you take for sleep, and does it totally solve the insomnia problem? Have you found anything that helps minimize the inevitable weight gain? Did the weight gain level off at some point or is it constant?
Sorry for all the questions, but there's a lot going on in my head right now... I am on 30mg starting today, and have felt no effects other than on day 1 where the first 15mg made me a little sleepy, and kind of silly. It also lifted my depression slightly for that one day. Now nothing. But I know that my dose needs to be much higher for a period of weeks before I can realistically expect anything.
Thanks,
Phoenix1
> Hi,
> Nardil has kept my major depression away for most of the past eleven years. I've stopped it four times for trials of newer meds with maybe less side effects. Each time this has resulted in the return of my major depression. Major side effects that are still with me; weight gain, insomnia(treated with Seroquel), presbyopia, delayed orgasm, and daytime somnolence. I will live with these over major depression. Each of my major depressions has been life threating.
>
> You are right. The medical term for "poop out" is tachyphylaxis.
> Take care,
> Jedi
>
>
> Medical Dictionary - tachyphylaxis
> Definition:
> Rapid appearance of progressive decrease in response to a given dose after repetitive administration of a pharmacologically or physiologically active substance.
> ------------------------------------------
>
>
>
>
>
> > It took a few weeks for the insomnia to really manifest itself. Will your pdoc let you hold on to one benzo for bedtime? I hope the insomnia doesn't happen, but I think more often than not it does. My pdoc and I decided to try MAOI's, hoping to get more than 6 months or a year at best as every single med has pooped out on me..when I see people post on here that have been on it for 20 years with no poop out, it gives me hope.
> >
> > I don't know the medical term for poop out, other than I think it might be called serotonin fatigue and I found another term on the web called tachyphylaxis. Good luck to you!
> >
> >
> > > Yikes, that's not good to hear. On the other hand, I've now heard the full spectrum of how people respond to Nardil so I will just have to wait and see how it affects me. My pdoc started me on an escalating dose: 15mg for 3 days, 30mg for 3 days, 45mg for a week, then 60mg for a week. The end goal depending on how I respond is 1mg/kg, per published literature. That would mean a 90mg dose. My insomnia is already bad, and my pdoc is tapering me off benzos completely, so I don't know what to expect. I have very high hopes that Nardil will help me. My only previous MAOI experience with Moclobemide was a huge but very short lived success.
> > >
> > > BTW, any ideas on how to prevent the dreaded Nardil poop-out before it happens? Is their a medical term for "poop-out" for lit searches?
> > >
> > > Thanks,
> > >
> > > Phoenix1
> > >
> > > > > Interesting that your insomnia was worse on >Nardil than on Parnate. I'd always heard the >reverse was more common.
> > > > >
> > > > > Phoenix1
> > > >
> > > > I thought insomnia couldn't get worse than when i was on parnate... boy was i wrong.. nothing will ever compare to how bad Nardil caused me insomnia when i was on it recently.
> > >
> > >
> >
> >
>
>
Posted by Jedi on December 31, 2007, at 12:23:24
In reply to Re: Parnate available-Phoenix1 » Jedi, posted by Phoenix1 on December 31, 2007, at 9:52:08
Hi Phoenix1,
Like your Doctor it seems that an antipsychotic is a big bang for "just" insomnia. But as we both know, if we can't sleep, we can't get well. I take only 25mg of Seroquel nightly. After over six months of use, I can count on being tired and ready for bed in half an hour. I sleep seven or eight hours nightly on it. I awake with a small hangover. This is fixed right up by a couple of cups of coffee. I am probably a little different than some people in that I am very sensitive to antihistamines. Even diphenhydramine hydrochloride(Benadryl) makes me really tired, but tolerance builds quickly. Seroquel is the best sleep aid I have used, mainly because of no tolerance to the somnolence effect. Seroquel's antagonism of histamine H1 receptors may explain this. Seroquel is used in dosages of hundreds of milligrams to treat psychotic conditions such as schizophrenia and bipolar disorder. 25mg just makes me sleepy.Once I reached an effective dose for me, I believe at first this was about 60mg; four or five weeks later the med kicked in. I have felt nothing like it with any other antidepressant. One day I was totally down and hopeless. The next day the answers were all clear. I did have some hypomania at first, but this felt good after being depressed for so long. The hypomania is not the true antidepressant effect of Nardil. When it goes away, some people interpret this as poop out. That is not the case. Be careful with hypomania, but don't let your MD take you off Nardil because of it. This to will pass.
I am currently on 90mg of Nardil. Because of my weight gain, I could probably be on more. The most quoted effective dose is 1mg/kg of body weight.
For me, I have been fighting the weight gain from the start. At one point I was up over 100 pounds. With a low carbohydrate diet and about two hours a day of exercise, I was able to lose about 70 pounds. Some of this has come back, but I'm still healthy and I am ready to work on it again. Oh, for the magic pill! For me, I think Nardil both lowers my metabolism and increases my natural urge for sweet carbohydrates. I think that is why the low carb diet works for me. If I don't eat any of it,(breads, chocolate, juices, etc.) my cravings are less. If I start on the sweet carbs, I can really binge on them.
Good luck. Nardil is "The Bomb" for atypical depression and social anxiety disorder.
Jedi
Posted by Jedi on January 1, 2008, at 1:54:50
In reply to Re: Nardil-Jedi, posted by Justherself54 on December 31, 2007, at 7:49:34
Hi Justherself,
I almost always can get by on just 25mg of Seroquel nightly. I have a very stong sedative reaction to antihistamines and since Seroquel is an antagonist at the histamine H1 receptors it is no wonder I react to a small amount of it. The difference in Seroquel and the antihistamines is I don't seem to build up a tolerance to the somnolence effect of Seroquel. I've taken it for over six months now with no tolerance to the sleepiness.When I first started Nardil. I took Traz for insomnia. It left me with a very hung over feeling. A lot worse than Seroquel.
Right now I'm taking 2mg of clonazepam. It doesn't make me tired, even if I take it in the morning. I was taking .5mg, then I had a trial of Parnate. I increased the clonazepam to 2mg during this trial. The Parnate seemed to be working OK then I had a rare spontaneous hypertensive reaction on it. Had to give it up and go back to Nardil. Then I ran into some finanancial difficulties that really raised my stress level. So I decided to stay on 2mg for a while. I plan on dropping the clonazepam after I get through these stressful times.
I've never taken zopicone. What does it do for you?
When I increase my Seroquel to 50mg and get up to use the bathroom in the night, I almost pass out. I think there is a synergism with the Nardil to increase the orthostatic hypotensive side effect. I try to stick to 25mg, but like I said, I'm very sensitive to antihistamines.
I hope 2008 brings you healthy times,
Jedi
> How much seroquel do you take at night? I'm currently taking 50 mg., .5 mg clonazapam and 7.5 zopicone..one would think that would get me through a good part of the night, but I continue to have frequent wakenings and always seem to be just on the "edge" of deep sleep..I can't take trazodone..
>
> It's a strange feeling, after I take my night meds, they hit pretty hard, but once I'm in bed, the tossing and turning begins..I'm wondering if increasing the seroquel will help..I'm reluctant to make another increase tho..any thoughts?
>
> And have a Happy New Year!
Posted by Phoenix1 on January 1, 2008, at 13:22:07
In reply to Re: Nardil-Jedi » Justherself54, posted by Jedi on January 1, 2008, at 1:54:50
I found the same thing when I tried trazodone. Hung over until the early afternoon...
I find Seroquel isn't enough for me. I've tried 25mg, 50mg, 75mg, and I still end up waking up in the middle of the night and not falling back asleep. If I take Seroquel relatively early (1-2 hours before I want to sleep) and then 7.5mg of zopiclone RIGHT before bed, I can often get a decent nights sleep (6 hours or so). For me, zopiclone could be replaced with a traditional benzo (oxazepam or temazepam) for the same effect. I find they all do about the same thing to me. Unfortunately, for me, I find I easily become dependent on them for sleep and it's tough to get back off them. But right now, I would rather just get sleep and worry about the rest later.
Phoenix1
>
> Hi Justherself,
> I almost always can get by on just 25mg of Seroquel nightly. I have a very stong sedative reaction to antihistamines and since Seroquel is an antagonist at the histamine H1 receptors it is no wonder I react to a small amount of it. The difference in Seroquel and the antihistamines is I don't seem to build up a tolerance to the somnolence effect of Seroquel. I've taken it for over six months now with no tolerance to the sleepiness.
>
> When I first started Nardil. I took Traz for insomnia. It left me with a very hung over feeling. A lot worse than Seroquel.
>
> Right now I'm taking 2mg of clonazepam. It doesn't make me tired, even if I take it in the morning. I was taking .5mg, then I had a trial of Parnate. I increased the clonazepam to 2mg during this trial. The Parnate seemed to be working OK then I had a rare spontaneous hypertensive reaction on it. Had to give it up and go back to Nardil. Then I ran into some finanancial difficulties that really raised my stress level. So I decided to stay on 2mg for a while. I plan on dropping the clonazepam after I get through these stressful times.
>
> I've never taken zopicone. What does it do for you?
>
> When I increase my Seroquel to 50mg and get up to use the bathroom in the night, I almost pass out. I think there is a synergism with the Nardil to increase the orthostatic hypotensive side effect. I try to stick to 25mg, but like I said, I'm very sensitive to antihistamines.
>
> I hope 2008 brings you healthy times,
> Jedi
>
>
>
>
>
>
> > How much seroquel do you take at night? I'm currently taking 50 mg., .5 mg clonazapam and 7.5 zopicone..one would think that would get me through a good part of the night, but I continue to have frequent wakenings and always seem to be just on the "edge" of deep sleep..I can't take trazodone..
> >
> > It's a strange feeling, after I take my night meds, they hit pretty hard, but once I'm in bed, the tossing and turning begins..I'm wondering if increasing the seroquel will help..I'm reluctant to make another increase tho..any thoughts?
> >
> > And have a Happy New Year!
>
>
>
Posted by Justherself54 on January 1, 2008, at 14:15:32
In reply to Re: Nardil-Jedi » Jedi, posted by Phoenix1 on January 1, 2008, at 13:22:07
I've had success with getting some sleep by doing similar to Phoenix1..I take my seroquel about an hour before bed..then just before bed I take the zopiclone..I have increased my zopiclone by 1/2 a tablet..not sure if I should be doing that but got some sleep the last 2 nights..
Trazadone was the worst thing I've ever tried..didn't sleep on it and felt like I had the worst hangover minus the booze all the next day! Sigh..sweet elusive sleep..
Posted by Nardilstarted2007 on January 16, 2008, at 23:35:28
In reply to Nardil in Canada, posted by Phoenix1 on December 26, 2007, at 14:23:54
> Hello,
>
> Have any of you Canadians recently had trouble filling a Nardil prescription? My local pharmacy has no stock, and they say they can't order it because the distributors are telling them that "it is not available from the manufacturer, ERFA". I phoned 40 local pharmacies and no one stocks it. The hospitals have it, but can't prescribe it because I'm an outpatient. ERFA has not returned email or phone calls. How am I supposed to get this prescription filled? Any suggestions? I've waited SO SO long for this, and now it's suddenly unavailable?
>
> Phoenix1Hello I just spoke to a ERFA rep (who said she was the only rep) and she told me Canada wont receive Nardil until 2012.I asked her why, she said there was a problem with the sodium levels. I said dont you think this is a bit crazy? and can I talk to anyone else there? She responded to drive my care more carefully when my supply runs out.
Furthermore she was talking to people in the background and it sounded like an afterwork party.
Im very upset with her coments. SHE STRICTLY SAID 4 year wait til its back. I dont believe her and should have got her name to file a complaint. Earlier I was told it will be coming back by Jan25th and 1 week despensing time.. That wouldnt be so bad because I have enough for a month and a half left.- I called: 1 888 922-3133
- from http://www.erfa-sa.com/Nardil/english/contact_en.html
This is the end of the thread.
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