Posted by Phoenix1 on December 31, 2007, at 9:52:08
In reply to Re: Parnate available-Phoenix1 » Justherself54, posted by Jedi on December 31, 2007, at 2:38:33
Hi Jedi,
Thanks for the answer... tachyphylaxis! Glad to hear you are doing well on Nardil. I have high hopes that it will be the answer for me too. I'm not sure what my doctor will let me stay on for the insomnia. He doesn't like the Seroquel, as he doesn't think it's a good long term sleep med. On the other hand, I have had issues with benzo tolerance and dependance, so he is wary there too. But I need to sleep!
Can I ask you some questions? How long did it take for the Nardil to "kick in" for you, and what dosage did it kick in at? What dosage are you on now? How much Seroquel do you take for sleep, and does it totally solve the insomnia problem? Have you found anything that helps minimize the inevitable weight gain? Did the weight gain level off at some point or is it constant?
Sorry for all the questions, but there's a lot going on in my head right now... I am on 30mg starting today, and have felt no effects other than on day 1 where the first 15mg made me a little sleepy, and kind of silly. It also lifted my depression slightly for that one day. Now nothing. But I know that my dose needs to be much higher for a period of weeks before I can realistically expect anything.
Thanks,
Phoenix1
> Hi,
> Nardil has kept my major depression away for most of the past eleven years. I've stopped it four times for trials of newer meds with maybe less side effects. Each time this has resulted in the return of my major depression. Major side effects that are still with me; weight gain, insomnia(treated with Seroquel), presbyopia, delayed orgasm, and daytime somnolence. I will live with these over major depression. Each of my major depressions has been life threating.
>
> You are right. The medical term for "poop out" is tachyphylaxis.
> Take care,
> Jedi
>
>
> Medical Dictionary - tachyphylaxis
> Definition:
> Rapid appearance of progressive decrease in response to a given dose after repetitive administration of a pharmacologically or physiologically active substance.
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> > It took a few weeks for the insomnia to really manifest itself. Will your pdoc let you hold on to one benzo for bedtime? I hope the insomnia doesn't happen, but I think more often than not it does. My pdoc and I decided to try MAOI's, hoping to get more than 6 months or a year at best as every single med has pooped out on me..when I see people post on here that have been on it for 20 years with no poop out, it gives me hope.
> >
> > I don't know the medical term for poop out, other than I think it might be called serotonin fatigue and I found another term on the web called tachyphylaxis. Good luck to you!
> >
> >
> > > Yikes, that's not good to hear. On the other hand, I've now heard the full spectrum of how people respond to Nardil so I will just have to wait and see how it affects me. My pdoc started me on an escalating dose: 15mg for 3 days, 30mg for 3 days, 45mg for a week, then 60mg for a week. The end goal depending on how I respond is 1mg/kg, per published literature. That would mean a 90mg dose. My insomnia is already bad, and my pdoc is tapering me off benzos completely, so I don't know what to expect. I have very high hopes that Nardil will help me. My only previous MAOI experience with Moclobemide was a huge but very short lived success.
> > >
> > > BTW, any ideas on how to prevent the dreaded Nardil poop-out before it happens? Is their a medical term for "poop-out" for lit searches?
> > >
> > > Thanks,
> > >
> > > Phoenix1
> > >
> > > > > Interesting that your insomnia was worse on >Nardil than on Parnate. I'd always heard the >reverse was more common.
> > > > >
> > > > > Phoenix1
> > > >
> > > > I thought insomnia couldn't get worse than when i was on parnate... boy was i wrong.. nothing will ever compare to how bad Nardil caused me insomnia when i was on it recently.
> > >
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poster:Phoenix1
thread:802726
URL: http://www.dr-bob.org/babble/20071225/msgs/803419.html