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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by MARTY on May 12, 2006, at 0:21:35
Yes, another one who doesn't know what to try next asking himself if MOCLOBEMIDE (MANERIX, AURORIX)could be the one for him.1. Could someone tell me how a AD med could be as side-effect free as it is said of MOCLO .. WHILE being efficacious, performant ?
2. As the FDA rejected the application of MOCLOBEMIDE ? If yes, why ?
3. Is RIMA MOCLOBEMIDE subject to the MAOI's Parnate and Nardil poop out party ? Is the feeling going up and down modulated by my 3 pills a day or does it give a uniform feeling through the day ?
I have 10 hellish day of withdrawal of Parnate.. I need some hope.. right now I dont know what to try next.. need helpthanks
Marty
Posted by Meri-Tuuli on May 12, 2006, at 2:23:16
In reply to MOCLOBEMIDE (MANERIX, AURORIX) RELOADED, posted by MARTY on May 12, 2006, at 0:21:35
Hi Marty,
I'm currently being presccribed moclobemide for depression/anxiety. I'll try and share what I know about moc!
Okay well, on paper moc sounds like a wonder drug. Sparse side effects, and a MAOI with little diet considerations. But alas, in real life it isn't as simple as that.
I know from the archives here that it sent Scott into a deep deep depression. Some others (who I can't remember the names of) took at and didn't feel anything at all - no side effects, but no AD effects either, they desrcibed it as a sugar pill!! Others here have been on it for four years and it pooped out. And others have found that it was great for them.
I get the impression that its sort of notorious for not really working that well as an AD in some people. Its been described as 'gentle'. Also, many people have found that you need to go pretty high with the dosages to get an effect - usually above the 600mg/day recommendation (up to 1200mg I believe). I think that this drug has probably been overlooked by many docs, simply because of the SSRI band wagon.
As for the FDA, well the story goes that the drug companies just didn't want to invest millions of dollars getting it throught the approval process because at that point in time, the patent was going to expire and it was going to go generic in one or two years, and wouldn't be worth the drug companies investment. So you can't get it in the USA. However, I have heard that docs in the US can ring up pharmacies/docs in countries that do have it approved (eg Canada, Europe) and get it that way.
I think there have been some instances of moc poop-out. But then, that happens with alot of pysch drugs.
I got a bunch of side effects when taking it - rash on my hands, headache, dizziness and light headedness. And thats was only on 150mg/day!!!!!!
I would say that it isn't as 'strong' as parnate, so it might be a disappointment to you. It inhibits 80% of MAO-A and 20% of B, meaning that it has slightly more effect on noradrenaline and sertonin than on dopamine. So I understand anyway.
You have to take the moc several days a day as it has a pretty short half life, something like 2-5 hours so I haven't been on it for long enough to know whether it 'feels' up and down during the day.
I'd be interested to know what others opioions are regarding this drug - there isn't that much available in the archives as I guess its not availble in the states.
Anyway, hope this helps.
Kind regards
Meri
Posted by Larry Hoover on May 12, 2006, at 8:12:30
In reply to MOCLOBEMIDE (MANERIX, AURORIX) RELOADED, posted by MARTY on May 12, 2006, at 0:21:35
>
> Yes, another one who doesn't know what to try next asking himself if MOCLOBEMIDE (MANERIX, AURORIX)could be the one for him.
>
> 1. Could someone tell me how a AD med could be as side-effect free as it is said of MOCLO .. WHILE being efficacious, performant ?Dunno how. I do know that I, Mr. Side-Effect, did not suffer side effects of any great significance while on it.
> 2. As the FDA rejected the application of MOCLOBEMIDE ? If yes, why ?
As noted by the esteemed Meri-Tuuli, it simply was not worth the expense to get FDA approval. The patent was indeed about to expire. By not getting it approved, however, they also blocked other companies from marketing it, unless those other companies were willing to bear the expense of clinical trials. Ain't gonna happen.
> 3. Is RIMA MOCLOBEMIDE subject to the MAOI's Parnate and Nardil poop out party ? Is the feeling going up and down modulated by my 3 pills a day or does it give a uniform feeling through the day ?I don't remember too much yo-yo goin' on (almost a decade back, now, so not too sure). It did poop-out though. Worked great, for a while. I remember exclaiming to my pdoc, "I got my brain back!"
>
> I have 10 hellish day of withdrawal of Parnate.. I need some hope.. right now I dont know what to try next.. need help
>
> thanks
> MartyI'm pretty sure you could just start taking moclobemide right now.
Lar
Posted by SLS on May 12, 2006, at 8:30:26
In reply to MOCLOBEMIDE (MANERIX, AURORIX) RELOADED, posted by MARTY on May 12, 2006, at 0:21:35
> Yes, another one who doesn't know what to try next asking himself if MOCLOBEMIDE (MANERIX, AURORIX)could be the one for him.
I hate to confuse you, but are you sure that you gave Parnate an adequate trial? I see too many people give up on a treatment after only a few weeks. It is not unusual for someone to experience ups and downs early in treatment. The ascent to remission is seldom a smooth one. It is a good sign that you experienced an antidepressant effect so early in treatment. However, it is not necessarily a bad sign that it did not continue uninterrupted. I think you need to give each dosage increase three weeks before evaluating its effectiveness. With Parnate, I don't think one can consider it a treatment failure until a dosage of 80mg is reached and given a minimum of 3 weeks to work.
Roche tried to get moclobemide approved in the US to treat social phobia in the 1990s. Roche felt that it had a better chance of having it approved for that indication since there were no drugs yet approved for that disorder. The studies to be submitted to the FDA did not show sufficient efficacy, and the drug was withdrawn from consideration.
Moclobemide tends to produce improvements in depression during the first two weeks of treatment at low dosages (150-300mg). Unfortunately, it usually becomes necessary to continually increase the dosage in order to maintain an antidepressant response. One can safely go up to 1200mg, but it doesn't usually make much difference.
Moclobemide was popular when it was first marketed because of its reversibility and favorable side effect profile. It was the most widely prescribed antidepressant in some countries for several years. However, its popularity declined quickly once its inferiority to other agents became apparent.
Of course, some people are very happy with moclobemide. It can work. However, I would place more confidence in the probability that the average person will respond more favorably to 80mg of Parnate than to 1200mg of moclobemide.
- Scott
Posted by Phillipa on May 12, 2006, at 22:20:51
In reply to Re: MOCLOBEMIDE (MANERIX, AURORIX) RELOADED, posted by SLS on May 12, 2006, at 8:30:26
Poor Meri her fist official pdoc appointment. Love Phillipa
Posted by Larry C on May 21, 2006, at 5:07:22
In reply to Re: MOCLOBEMIDE (MANERIX, AURORIX) RELOADED, posted by Phillipa on May 12, 2006, at 22:20:51
I am considering trying Moclobemide but I also have
problems with antidepressants.I tried Moclobemide 9 years for a week but found the side-effects
too severe.Mind you I began at 300 mg per day.
At this point I would start at 75 mg twice per day.
Are a lot of people becoming more depressed after taking
Moclobemide?I seem to get that from some antidepressants as well.
Has anyone experienced headaches or insomnia from the
Moclobemide?I recently tried Lexapro aka Cipralex but got severe
headaches from it.I thought about Wellbutrin but most users seem to
complain about headaches from it.So Moclobemide wins by default or does it?
Posted by MARTY on May 21, 2006, at 17:11:45
In reply to Re: MOCLOBEMIDE (MANERIX, AURORIX) RELOADED, posted by Phillipa on May 12, 2006, at 22:20:51
Wow.. I think I've miss a lot of post here. I think I may haven't check the "notify you of later follow-ups to this thread" ...So I've read all your post and thanks you for all the info and suggestion. Right now I'm on day 4, maybe 5 :P let's say 5.. 150mg BID and I think it is fine so far, except for a pressure I feel in the head and the feeling their is a kind of fast build up their sometimes; makes me feel like I was going to have a seizure or a panic attack. Never had one or the other .. so it's just a way to describe it. I had the same thing on Nardil at first and I learn to forget them. anyway...
SLS, About Parnate.. the biggest problem I had was my BP. It increase 30 points for 30mg, so I couldn't increase the dosage.. my Pdoc just told me to withdraw. So that's it.. but I think you're right on everything you said.
Wish you all a great day
Marty
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