![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 18 of 18. This is the beginning of the thread.
Posted by jrbecker on February 23, 2006, at 11:11:44
http://www.medscape.com/viewarticle/524082?rss
FDA Safety Changes: Xyrem and NovoSeven CME/CE
News Author: Yael Waknine
Release Date: February 22, 2006;
--------------------------------------------------------------------------------Feb. 22, 2006 — The U.S. Food and Drug Administration (FDA) has approved safety labeling revisions to advise of the risks for depression, confusion, and other neuropsychiatric adverse events in patients treated with sodium oxybate oral solution; and postmarketing adverse events and the potential risk for thrombotic events in patients receiving coagulation factor VIIa injection.
Sodium Oxybate (Xyrem) Linked to Risks for Depression and Confusion
On November 18, 2005, the FDA approved safety labeling revisions for sodium oxybate (Xyrem oral solution, made by Orphan Medical, Inc) to warn of the risk for depression, confusion, and other neuropsychiatric adverse events associated with its use.In clinical trials, 3.2% of patients receiving sodium oxybate reported depressive symptoms. Although most cases required no changes in treatment, 4 patients (<1%) discontinued therapy as a result of these symptoms.
In the placebo-controlled clinical trial of sodium oxybate at fixed nightly doses of 3, 6, and 9 g, one case of depression was reported at the 3-mg dose. In another trial of the drug uptitrated from a 4.5-g nightly dose, the incidence of depression was 1 (1.7%), 1 (1.5%), 2 (3.2%), and 2 (3.6%) for the placebo and 4.5-, 6-, and 9-mg doses, respectively.
During clinical trials, 2 suicides and 1 attempted suicide were reported in patients with a previous history of depressive disorder. In one suicide, sodium oxybate was used in conjunction with other drugs; the other suicide occurred in a patient not receiving the medication. Sodium oxybate was the only drug involved in the attempted suicide.
The FDA notes that the emergence of depression in patients treated with sodium oxybate requires careful and immediate evaluation. Patients with a prior history of depressive illness and/or suicide attempt should be monitored carefully for the emergence of depressive symptoms during treatment.
The overall rate of confusion was 2.6% in patients treated with sodium oxybate at doses from 6 to 9 g per night during clinical trials. Data from the fixed-dose study revealed a dose-response relationship for confusion, with 17% of patients at 9 g per night reporting the condition. In this trial, all cases resolved soon after termination of therapy.
In the majority of cases across all clinical trials, confusion resolved soon after discontinuation of treatment or with continued therapy. The FDA advises that all patients who become confused during treatment be evaluated fully to determine the need for intervention.
Other reported neuropsychiatric events in sodium oxybate-treated patients included psychosis, paranoia, hallucinations, and agitation. The FDA recommends careful and immediate evaluation of emerging thought disorders and/or behavioral abnormalities in patients receiving sodium oxybate.
Sodium oxybate is indicated for the treatment of excessive daytime sleepiness and cataplexy in patients with narcolepsy.
It is available only through the Xyrem Success Program, which requires enrollment of prescribers and patients in a registry and confirmation that both have been educated regarding the risks and proper use of the medication. All prescribing forms and documents verifying education must be sent to a centralized pharmacy prior to shipping of sodium oxybate to the patient.
Prescribing forms and educational materials may be obtained by contacting the pharmacy at 1-866-XYREM88 (1-866-997-3688). Follow-up visits at 3-month intervals are recommended and healthcare professionals are expected to report all serious adverse events to the manufacturer.
Coagulation Factor VIIa Injection (NovoSeven) May Be Linked to Thrombotic Adverse Events
The FDA approved in November 2005 revisions to the safety labeling for recombinant coagulation factor VIIa intravenous injection (NovoSeven, made by Novo Nordisk) to advise of postmarketing adverse events and to warn of the potential risk for thrombotic adverse events associated with its use.Postmarketing adverse events related to use of factor VIIa for labeled and nonlabeled indications have included high D-dimer levels and consumptive coagulopathy and isolated cases of anaphylactic and other hypersensitivity reactions. Thromboembolic events, such as myocardial infarction, myocardial ischemia, cerebral infarction and/or ischemia, thrombophlebitis, arterial thrombosis, and deep vein thrombosis and related pulmonary embolism, have also been reported.
The FDA notes that evaluation and interpretation of these events is confounded by underlying diagnoses, concomitant medications, preexisting conditions, and the limitations inherent in passive surveillance. Because postmarketing reports are derived from a population of uncertain size on a voluntary basis, their frequency and the causal role of factor VIIa remain unclear.
While the risk for arterial and venous thromboembolic adverse events after treatment with the product in patients with hemophilia and inhibitors is unknown, it is considered to be low.
Patients with disseminated intravascular coagulation, advanced atherosclerotic disease, crush injury, septicemia, or those receiving concomitant treatment with activated-nonactivated prothrombin complex concentrates may be at increased risk of developing thrombotic events due to circulating tissue factor or predisposing coagulopathy.
Although the extent of the risk for thrombotic adverse events associated with use of the product in patients without hemophilia is also unknown, data from a clinical study has indicated a potential increased risk for arterial thromboembolic events, including myocardial ischemia, myocardial infarction, cerebral ischemia, and/or infarction.
Coagulation factor VIIa [recombinant] intravenous injection is indicated for the prevention and treatment of bleeding episodes during surgical interventions or invasive procedures in hemophilia A or B patients with inhibitors to factor VIII or factor IX. It is also indicated for the treatment of bleeding episodes in patients with congenital factor VII deficiency.
Source: http://www.fda.gov/medwatch/safety/2005/nov05.htm
Learning Objectives for This Educational Activity
Upon completion of this activity, participants will be able to:
Evaluate the risk for neuropsychiatric adverse events in patients receiving therapy with sodium oxybate.
Describe the risk management program for sodium oxybate.
Identify the risk for thrombotic events associated with use of factor VIIa in patients with and without hemophilia.
Pearls for Practice
Sodium oxybate is linked to risks for depression, confusion, and other neuropsychiatric events. Depression was reported in 3.2% of sodium oxybate-treated patients, and patients with a prior history of depression and/or suicide attempt should be monitored carefully. Confusion was dose-related and occurred in 2.6% of patients overall; most cases resolved with continuation or termination of therapy.
Sodium oxybate is only available through the Xyrem Success Program, which requires clinician and patient registration and education regarding risks and proper use of the drug. Prescriptions are filled and shipped to the patient from a centralized pharmacy. Follow-ups are recommended at 3-month intervals, and all serious adverse events should be reported to the manufacturer.
The risk for thrombotic events after use of factor VIIa in patients with hemophilia and inhibitors is unknown but considered to be low. Data from a clinical study indicate a potential increased risk for arterial thrombotic events in patients without hemophilia receiving the product.
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Target Audience
This article is intended for primary care clinicians, surgeons, cardiologists, psychiatrists, and other specialists who care for narcoleptic patients with excessive daytime sleepiness and cataplexy, patients with hemophilia A or B undergoing surgical interventions or invasive procedures, and patients with congenital factor VII deficiency.Goal
The goal of this activity is to provide medical news to primary care clinicians and other healthcare professionals in order to enhance patient care.
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As an organization accredited by the ACCME, Medscape requires everyone who is in a position to control the content of an education activity to disclose all relevant financial relationships with any commercial interest. The ACCME defines "relevant financial relationships" as financial relationships in any amount, occurring within the past 12 months, including financial relationships of a spouse or life partner, that could create a conflict of interest.
Medscape encourages Authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration, at first mention and where appropriate in the content.
News Author
Yael Waknine
is a freelance writer for Medscape.
Disclosure: Yael Waknine has disclosed no relevant financial relationships.Clinical Reviewer
Gary Vogin, MD
Senior Medical Editor, Medscape
Disclosure: Gary Vogin, MD, has disclosed no relevant financial relationships.CME Author
Yael Waknine
is a freelance writer for Medscape.
Disclosure: Yael Waknine has disclosed no relevant financial relationships.
Posted by willyee on February 23, 2006, at 17:42:57
In reply to New FDA labelling for Xyrem warns of depression, posted by jrbecker on February 23, 2006, at 11:11:44
Ok,lets fix this right here,GHB is gamma hydroxy butrycic acid,meaning the sodium hydroxide carries it into the brain.
If used CORRECTLY,meaning by someone who knows the difference of a dose for sleep of a WHOPPING MIND BLOWING 3-4 grams,and someone who knows the dose for anxiety and depression which could be as low as 200mg and unless reason be it should be really no higher than 2.5 grams ,some individuals are heavy and some are just tolrtant to it.
Never the less 4 grams is either a recreational dose or a sleep dose.So thats aside right there.
Now ghbs actions is similiar in some way to almost all of your anti convulsant mood stablizers,its calming,overall ehances gaba,muscle relaxation etc.
Differnce,is unlike say depakote that is calming but flatening ghb can have a slight eupohria to it,however it is not a anti depressant in its own right.It in my opinion should never be used therputicaly alone,instead it should be combined with a Anti depressant,prefably a semi stimulating one.
So it should not be surprising to anyone that coninued use of ghb alone in the treatment of depression will eventualy lead to first much worse depression,horrable rebound anxiety,and well just imahine using xanax as a sole med,yeah feels good at first,but how quick will xanax go from a calming augment excellent med to a nightmare if used alone,how severe will tolerance build,rebound build,depression and a list of other things.I know having used xyrem in conjunction with parnate that it cant be the sole treatment,but he double hockey sticks if it doesent beat every single moood stablizer u could try to add.
Xyrem is all about patienace,the response curve is steep,and swift,one must slowly learn the proper dose,because a perfect augmenting dose allowing freedom from anxiet,ehnacing a Anti depressant,and ehnacing social behaviour can in a SNAP of a droplet turn to a stupour high.I dont advise no one to use xyrem thepruticaly unless they are on some sort of anti depressant or day time stimulant.
Its like drinking beer everyday,in about a week youll be crying ur eyes out in despair.I know its just helped me 1000 percent out my social slump.
Posted by tessellated on February 23, 2006, at 17:56:22
In reply to New FDA labelling for Xyrem warns of depression, posted by jrbecker on February 23, 2006, at 11:11:44
i found the generic and cheap as dirt form of xyrem to be a wonderful (though mildly habit forming) antidepressant.
i have a hunch that the variability that AD's have on neurotransmission does contribute in some form to some individuals suicidal ideation; perhaps through an alteration in NT impulse modulation, or as an increased attenuation of the electrical waves. as in my experience suicidal thoughts ONLY occur during severe trajedy or/or AD treatment. I see however a vast differential between ideation and action, and therefore do not fault AD therapy. Ideation is abstract, and action physical. Philosophically, verything changes particularly emotions, and to act radically and purely upon one's emotions roots oneself in an experience of endlessness or permanence that is non existant.I would think seriously about these issues in children, and those who cannot objectify themselves whatsoever. As it would be unfortunate for these associative affects to impare the technology, or the ethics of the field.
FYI: the term ethically refers to the act of giving another "drugs".
Posted by willyee on February 23, 2006, at 17:59:59
In reply to Re: New FDA labelling for Xyrem warns of depression, posted by tessellated on February 23, 2006, at 17:56:22
> i found the generic and cheap as dirt form of xyrem to be a wonderful (though mildly habit forming) antidepressant.
> i have a hunch that the variability that AD's have on neurotransmission does contribute in some form to some individuals suicidal ideation; perhaps through an alteration in NT impulse modulation, or as an increased attenuation of the electrical waves. as in my experience suicidal thoughts ONLY occur during severe trajedy or/or AD treatment. I see however a vast differential between ideation and action, and therefore do not fault AD therapy. Ideation is abstract, and action physical. Philosophically, verything changes particularly emotions, and to act radically and purely upon one's emotions roots oneself in an experience of endlessness or permanence that is non existant.
>
> I would think seriously about these issues in children, and those who cannot objectify themselves whatsoever. As it would be unfortunate for these associative affects to impare the technology, or the ethics of the field.
>
> FYI: the term ethically refers to the act of giving another "drugs".
>
>
Dude im not gonna lie to you,you just went whoosh over my head lol i only play a semi smart guy on the net,i have no idea what u just said,but it sounded great lol.
Posted by Phillipa on February 23, 2006, at 19:58:56
In reply to Re: New FDA labelling for Xyrem warns of depression, posted by willyee on February 23, 2006, at 17:59:59
I think and I just think that xyrem is GHB the date rape drug. Of course I could be wrong. Yeah I know they do go over my head most of the time. Fondly, Phillipa
Posted by tessellated on February 23, 2006, at 21:21:14
In reply to Re: New FDA labelling for Xyrem warns of depression » willyee, posted by Phillipa on February 23, 2006, at 19:58:56
Phillipa,
Now lets ask ourselves what is the oldest most prevalent statistically significant date rape drug?
RESEARCH SAYS: alcohol.
Just as tryptophan was banned prior to the release of prozac.
So was GHB banned prior to and legally necessary to the release of XYREM. You cannot patent dopamine, serotonin, norepinephrine, or anything that comes off a plant or is a product of nature. Only after it is outlawed and then scheduled, can a company control the (patent) profit over the distribution of said molecule. If they banned oxygen because it makes people feel good, we'd have to pay bucks for it. seriously. bottled water is more expensive now than gasoline....There is a major differentiation between the hype and the the science. I do believe that GHB/XYREM should be controlled as it has similar adversive actions similar to benzodiazapines.
Gamma hydroxybutyrate is in your body and active this moment.
It is an endogenous compound.Yes it causes one to loose consciousness. And is as far as I understand imparts a natural form of sleep architecture and therefore justifies its use in narcolepsy. It provides a form of sleep narcoleptics do not produce naturally. And is the best solution on the market.
If you want to cause amnesia give someone AMBIEN, XANAX, ALCOHOL. Why isn't Ambien considered a date rape drug?
Posted by tessellated on February 23, 2006, at 21:21:31
In reply to Re: New FDA labelling for Xyrem warns of depression » willyee, posted by Phillipa on February 23, 2006, at 19:58:56
Phillipa,
Now lets ask ourselves what is the oldest most prevalent statistically significant date rape drug?
RESEARCH SAYS: alcohol.
Just as tryptophan was banned prior to the release of prozac.
So was GHB banned prior to and legally necessary to the release of XYREM. You cannot patent dopamine, serotonin, norepinephrine, or anything that comes off a plant or is a product of nature. Only after it is outlawed and then scheduled, can a company control the (patent) profit over the distribution of said molecule. If they banned oxygen because it makes people feel good, we'd have to pay bucks for it. seriously. bottled water is more expensive now than gasoline....There is a major differentiation between the hype and the the science. I do believe that GHB/XYREM should be controlled as it has similar adversive actions similar to benzodiazapines.
Gamma hydroxybutyrate is in your body and active this moment.
It is an endogenous compound.Yes it causes one to loose consciousness. And is as far as I understand imparts a natural form of sleep architecture and therefore justifies its use in narcolepsy. It provides a form of sleep narcoleptics do not produce naturally. And is the best solution on the market.
If you want to cause amnesia give someone AMBIEN, XANAX, ALCOHOL. Why isn't Ambien considered a date rape drug?
Posted by Phillipa on February 23, 2006, at 21:35:42
In reply to Re: New FDA labelling for Xyrem warns of depression, posted by tessellated on February 23, 2006, at 21:21:31
In just my experience only I have taken all the meds you have listed. And none of them have ever even put me to sleep let alone knock me out. Now maybe if one take a huge amt of any of these meds or alchohol they will act the same. Are you saying GHB is used for narcolepsy? I don't understand as narcolepsy people just fall out . Fondly, Phillipa
Posted by tessellated on February 23, 2006, at 21:47:33
In reply to Re: New FDA labelling for Xyrem warns of depression » tessellated, posted by Phillipa on February 23, 2006, at 21:35:42
phillipa,
right... it is counterintuitive.
the treatment of narcolepsy (passing out uncontrollably), or worse cataplexy (a loss of all muscle control) with a depressant is similar to the way stimulants make ADD, ADHD, or simply hyperactive kids calm.
specifically, the theory goes that it complements a certain sleep pattern they (narcoleptics, cataplectics) do not self induce.
it gives them a form of sleep they do not experience normally.
it's delta wave i believe.
xyrem gives a part of their brain a brake that it doesn't otherwise have.
Posted by willyee on February 26, 2006, at 2:17:49
In reply to Re: New FDA labelling for Xyrem warns of depression » willyee, posted by Phillipa on February 23, 2006, at 19:58:56
> I think and I just think that xyrem is GHB the date rape drug. Of course I could be wrong. Yeah I know they do go over my head most of the time. Fondly, Phillipa
Phillpa there is no such thing as a "date rape drug" is absurd.First offf xyrem,ghb or whatever form has no buisnes in a bar or being put in someones drink,that is a criminal act,and has nothing to do with the drug but everything to do with the individual.Why the date rape hsyteria,well for the FDA to totaly BAN a LEGAL nutrient,meaning have it off the shelves immediatly,without having it looked into,they have to show that the substances poses an IMMEDITIATE hazrd to the public,otherwise there are steps that need to be taken before a legal supplement is banned,otherwise it can not be just yanked off the shelves.
So thus the date rape campaign,now im not gonna say ghb has never been used in such a way,but its no more potent in a drink than a hand ful of crushed benzos,if one is intent on getting a girl to pass out from drugs there are many avenues to go.
The average person doesent even know what ghb is until u say......"u know ghb the date rape drug" THEN THEY go ohhhhhhh right ok.
GHB was never this HUGE epidemic,it was used illegaly no more than any scripts are.
But what is a fact is not long after,in fact DURING the ban oprhan began work on xyrem.
Xyrem was in plans to become a presciption drug years and years ago,so two things come to mind,first i dont care what reasoning critics use,you dont come ot and say a drug is toxic,and shoould not be consumed,then say oh unless its STRICTLY montoered then only for some.
Also example 100 grams of ghb someone might have used would prob have cost 100 dollers,xyrem cost for that,at LEAST 500-600 dollers.
Its a big lie.
And anyone bent on telling me different should at least know more than the hype storys about ghb,i dont wanna hear those.
What they should know,is ghb was the primary work of A ONE DR HENRI LABRORIT,the same CHEMIST
Who was responsable for bringing in one of the first anti psyctoics THORAZINE which at the time finaly allowed even the thought of letting patients out of instiuitons.
The same man who worked extensivly with ghb,and thorazine was also nominated for the NOBEL prize,so ghb was not this drug whipped up in some teenagers dorm,however the fda loves it when people easly buy that stuff without asking questions,so before anyone wants to jump in about ghb being this horrable thing,i suggest a google on the term DR HENRI LABORIT GHB NOBEL PRIZE and see what comes up.
Look at typohan,i cant spell it now its too late,decades later this simple amino acid is still not available on health store shelves,lol that is absurd,the whole trypto fiasco was proven to be the case of the main manifcaturer years ago,tryptohan is no matter how mad the fda might want u to think other wise a simple amino acid,and should be on the shelves next to the rest of them.The fact that trypothan places a extremly significant role in serotionion could only be a conspriacy theory,one im willing to accept.
Posted by tessellated on February 26, 2006, at 6:57:32
In reply to Re: New FDA labelling for Xyrem warns of depression, posted by willyee on February 26, 2006, at 2:17:49
Tryptophan was banned just before the release of Prozac.
Coincidence????
Posted by jerrympls on February 27, 2006, at 23:07:48
In reply to New FDA labelling for Xyrem warns of depression, posted by jrbecker on February 23, 2006, at 11:11:44
This doesn't mean anything to me - meanign I'd still take it if my doc prescribed it. Why? Because ANTIDEPRESSANTS can and do cause depression, hallucinations, psychosis, etc. Why don't AD's have more warnings that "This may cause you to be more depressed than you ever have been in your life!" This discussion board is proof that antidepressants CAUSE depression!
Just my 2 cents.
Posted by jerrympls on February 27, 2006, at 23:15:08
In reply to tryptophan ban » willyee, posted by tessellated on February 26, 2006, at 6:57:32
> Tryptophan was banned just before the release of Prozac.
> Coincidence????I wouldn't be surprised if Lilly got tryptophan banned - drug companies are cruel and greedy. It's interesting that it got banned because of ONE "bad" batch. Yes, 4 people died from developing complications -but was the answer to ban it forever? NO WAY. Wellbutrin causes seizures, Viagra can kill you if there's a sudden drop in your blood pressure, hormone replacement therapy causes blood clots, cancer and strokes, etc etc etc and they're not banned. I talked to a psychotherapist about tryptophan and he said it did wonders for many with depression/insomnia, etc. back in the day. So of course the drug companies want it out of the way - they want MONEY and nothing to stand in their way of getting it.
Posted by Larry Hoover on February 28, 2006, at 9:20:44
In reply to Re: New FDA labelling for Xyrem warns of depression, posted by willyee on February 26, 2006, at 2:17:49
> Look at typohan,i cant spell it now its too late,decades later this simple amino acid is still not available on health store shelves,lol that is absurd,the whole trypto fiasco was proven to be the case of the main manifcaturer years ago,tryptohan is no matter how mad the fda might want u to think other wise a simple amino acid,and should be on the shelves next to the rest of them.
Just for the record, the ban on tryptophan was lifted in 1994.
http://vm.cfsan.fda.gov/~dms/ds-tryp1.html
Guess which event got more publicity, the original ban, or the lifting of the ban?
As it stands right now in the United States, tryptophan sold for human consumption carries a legal liability on the manufacturer. It is not illegal to sell it for human use, but the tryptophan that is sold for human consumption is vastly over-priced. I believe that suppliers are taking advantage of the situation to make windfall profits.
The specific improper purification process that caused the contamination of *one batch* of tryptophan is no longer used anywhere in the world. Moreover, every single batch of tryptophan is tested for the contaminant that led to EMS. It is, in my perhaps not so humble opinion, impossible to obtain dangerous tryptophan.
To avoid the price-gouging on human-use tryptophan, I use veterinary grade tryptophan. It's the same stuff.
http://www.buygpdirect.com/gpefeed.htm
I use the ultra-pure (well down the page).
Lar
Posted by jerrympls on February 28, 2006, at 20:15:27
In reply to tryptophan *not* banned for over a decade!, posted by Larry Hoover on February 28, 2006, at 9:20:44
Hey Lar-
Thanks for the info!! So do you take tryptophan regularily then? Does it help you? If so - in what ways?????? I'm anxious to hear about its effects!
Thanks again!
Jerry
> > Look at typohan,i cant spell it now its too late,decades later this simple amino acid is still not available on health store shelves,lol that is absurd,the whole trypto fiasco was proven to be the case of the main manifcaturer years ago,tryptohan is no matter how mad the fda might want u to think other wise a simple amino acid,and should be on the shelves next to the rest of them.
>
> Just for the record, the ban on tryptophan was lifted in 1994.
>
> http://vm.cfsan.fda.gov/~dms/ds-tryp1.html
>
> Guess which event got more publicity, the original ban, or the lifting of the ban?
>
> As it stands right now in the United States, tryptophan sold for human consumption carries a legal liability on the manufacturer. It is not illegal to sell it for human use, but the tryptophan that is sold for human consumption is vastly over-priced. I believe that suppliers are taking advantage of the situation to make windfall profits.
>
> The specific improper purification process that caused the contamination of *one batch* of tryptophan is no longer used anywhere in the world. Moreover, every single batch of tryptophan is tested for the contaminant that led to EMS. It is, in my perhaps not so humble opinion, impossible to obtain dangerous tryptophan.
>
> To avoid the price-gouging on human-use tryptophan, I use veterinary grade tryptophan. It's the same stuff.
>
> http://www.buygpdirect.com/gpefeed.htm
>
> I use the ultra-pure (well down the page).
>
> Lar
Posted by Larry Hoover on March 1, 2006, at 11:58:41
In reply to Re: tryptophan *not* banned for over a decade! » Larry Hoover, posted by jerrympls on February 28, 2006, at 20:15:27
> Hey Lar-
>
> Thanks for the info!! So do you take tryptophan regularily then?Regularly? No. No I don't. I take it as needed. P.r.n., quite literally. When I think of it.
> Does it help you? If so - in what ways?????? I'm anxious to hear about its effects!
>
> Thanks again!
> JerryFor many supps, I am anything but a regular consumer thereof. It is a peculiarity of my existence, the very essence of Lar-ness, that I am discombobulated with respect to time and calendar. Clocks and calendars are the bane of my existence. Some people are dyslexic. I am dyscalendaric. It is a huge struggle for me to do anything by routine. I would probably benefit immensely from having a personal assistant, but I can only afford me. And, as a personal assistant, I suck. I simply forget to use my supps.
So, I do offer advice about using substances that I do not myself regularly use. The key point here is "regular". Far better for me, to simply stick to the concept of "use", all by itself.
When I use tryptophan, I am calmer, more resilient, and I sleep better. The veterinary tryptophan that I linked to is a very poorly soluble powder. You need a blender to get it wet properly. So, I just blend some into orange juice, or whatever I've got. I use soy milk, too, even though there are competing amino acids in there. By loading with the tryptophan, you're still going to improve the equilibrium, shifting it towards tryptophan uptake by the brain.
You need B-vitamins and zinc to optimize utilization of the tryptophan.
Lar
Posted by willyee on July 12, 2006, at 20:37:07
In reply to Re: tryptophan *not* banned for over a decade! » jerrympls, posted by Larry Hoover on March 1, 2006, at 11:58:41
> > Hey Lar-
> >
> > Thanks for the info!! So do you take tryptophan regularily then?
>
> Regularly? No. No I don't. I take it as needed. P.r.n., quite literally. When I think of it.
>
> > Does it help you? If so - in what ways?????? I'm anxious to hear about its effects!
> >
> > Thanks again!
> > Jerry
>
> For many supps, I am anything but a regular consumer thereof. It is a peculiarity of my existence, the very essence of Lar-ness, that I am discombobulated with respect to time and calendar. Clocks and calendars are the bane of my existence. Some people are dyslexic. I am dyscalendaric. It is a huge struggle for me to do anything by routine. I would probably benefit immensely from having a personal assistant, but I can only afford me. And, as a personal assistant, I suck. I simply forget to use my supps.
>
> So, I do offer advice about using substances that I do not myself regularly use. The key point here is "regular". Far better for me, to simply stick to the concept of "use", all by itself.
>
> When I use tryptophan, I am calmer, more resilient, and I sleep better. The veterinary tryptophan that I linked to is a very poorly soluble powder. You need a blender to get it wet properly. So, I just blend some into orange juice, or whatever I've got. I use soy milk, too, even though there are competing amino acids in there. By loading with the tryptophan, you're still going to improve the equilibrium, shifting it towards tryptophan uptake by the brain.
>
> You need B-vitamins and zinc to optimize utilization of the tryptophan.
>
> LarWhen i used it i mixed it in one of those baby foods,swirled it around,not sure which brand i bought but the one with hardly any protein as not to compete with the trypthan,i figured since it wont dissovle,ill mix it in,and it did mix in well with the thick baby food,hardly noticable too.
Posted by Susana M on July 15, 2006, at 11:17:11
In reply to Re: tryptophan *not* banned for over a decade!, posted by willyee on July 12, 2006, at 20:37:07
>
> >
> > When I use tryptophan, I am calmer, more resilient, and I sleep better. The veterinary tryptophan that I linked to is a very poorly soluble powder. You need a blender to get it wet properly. So, I just blend some into orange juice, or whatever I've got. I use soy milk, too, even though there are competing amino acids in there. By loading with the tryptophan, you're still going to improve the equilibrium, shifting it towards tryptophan uptake by the brain.
> >
> > You need B-vitamins and zinc to optimize utilization of the tryptophan.
> >
> > LarQuestion:
How much do you take a day in mgs.? I just followed your advise and bought some Tryptophane from the site you recomended now since I'm not a horse!! I need to know how much a should I take a day? also.. I unfortunatelly ordered the normal brand ..not the "ultra pure form" I just ordered it from the site and didn't realize there was another type ( the one you recommended )
Susana M.
This is the end of the thread.
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