![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by jrbecker on October 19, 2005, at 10:21:50
http://www.news-medical.net/?id=13841
Drug company warns of risk of liver problems with antidepressant
Pharmaceutical News
Published: Tuesday, 18-Oct-2005
The warning about possible liver-related problems with the depression drug, Cymbalta, has been expanded and doctors are being cautioned against its use in chronic liver disease patients.
Drug company Eli Lilly has issued a new label for the antidepressant, known generically as duloxetine, which also includes reports of hepatitis, jaundice and other liver-related problems in patients using the drug.The information is displayed on the U.S. Food and Drug Administration web site.
In a letter to doctors in early October the company said there had been some reports indicating that patients with pre-existing liver disease who take duloxetine may have an increased risk for further liver damage.
Cymbalta, which is also approved to treat a type of nerve damage caused by diabetes, has been known to cause liver problems.
The initial label also warned against using the drug with alcohol.
According to the new label, Cymbalta should ordinarily not be prescribed to patients with substantial alcohol use or evidence of chronic liver disease.
Posted by Phillipa on October 19, 2005, at 19:24:07
In reply to Lilly Warns of Liver-Related Toxicity withCymbalta, posted by jrbecker on October 19, 2005, at 10:21:50
And it's only been out a year! Fondly, Phillipa
Posted by Glydin on October 19, 2005, at 21:35:31
In reply to Re: Lilly Warns of Liver-Related Toxicity withCymbalta » jrbecker, posted by Phillipa on October 19, 2005, at 19:24:07
"In a letter to doctors in early October the company said there had been some reports indicating that patients with pre-existing liver disease who take duloxetine may have an increased risk for further liver damage."
The key part to that may be PRE-EXISTING. Meds are liver sensitized for the most part and toxic problems generally arise with most any class of meds in patients who are hepatic or renal compromised. Cymbalta’s formulation is so close to Prozac, I wonder if that was a finding with Prozac also.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.